Left ventricular end-diastolic dimension and septal e′ are predictors of cardiac index at rest, while tricuspid annular plane systolic excursion is a predictor of peak oxygen uptake in patients with pulmonary hypertension

Nakano, Yoshihisa; Okumura, Naoki; Adachi, Shiro; Shimokata, Shigetake; Tajima, F.; Kamimura, Yoshihiro; Murohara, Toyoaki; Kondo, Takahisa

doi:10.1007/s00380-017-1086-0

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…The function of left ventricular is below average in most patients with hemodialysis, in which LVDd is considered as a predictor of mortality (Inoue, Ogawa, Iwabuchi, Otsuka, & Nitta, 2012). LVEDd, as an important predictor of cardiac index, is exhibited in high levels in children with acute myocarditis, which is closely associated with adverse outcomes (Kim et al, 2017;Nakano et al, 2018). In addition to LVED being highly exhibited in children with acute myocarditis, evaluation of left ventricular systolic function is usually conducted by measurement of FS and ejection with left ventricular dysfunction (Yamaguchi et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Retracted: IRAK3 gene silencing prevents cardiac rupture and ventricular remodeling through negative regulation of the NF‐κB signaling pathway in a mouse model of acute myocardial infarction

Wang

et al. 2018

Journal Cellular Physiology

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Cardiac rupture and ventricular remodeling are recognized as the severe complications and major risk factors of acute myocardial infarction (AMI). This study aims to evaluate the regulatory roles of interleukin‐1 receptor‐associated kinase 3 (IRAK3) and nuclear factor‐κB (NF‐κB) signaling pathway in cardiac rupture and ventricular remodeling. Microarray analysis was performed to screen AMI‐related differentially expressed genes and IRAK3 was identified. The models of AMI were established in male C57BL/6 mice to investigate the functional role of IRAK3. Afterwards, lentivirus recombinant plasmid si‐IRAK3 was constructed for IRAK3 silencing. Next, cardiac function parameters were measured in response to IRAK3 silencing. The regulatory effects that IRAK3 had on myocardial infarct size and the content of myocardial interstitial collagen were analyzed. The regulation of IRAK3 silencing on the NF‐κB signaling pathway was further assayed. The obtained results indicated that highly expressed IRAK3 and activated NF‐κB signaling pathway were observed in myocardial tissues of mouse models of AMI, accompanied by increased expression of matrix metalloproteinase (MMP)‐2/9 and tissue inhibitor of metalloproteinase 2 (TIMP‐2). Notably, IRAK3 gene silencing inhibited the activation of NF‐κB signaling pathway. Furthermore, IRAK3 gene silencing led to the decreased thickness of infarct area and collagen content of myocardial interstitium, alleviated diastolic, and systolic dysfunctions, as well as, facilitated cardiac functions in mice with AMI, corresponding to decreased expression of MMP‐2/9 expression and increased expression of TIMP‐2. Taken together, silencing of IRAK3 inactivates the NF‐κB signaling pathway, and thereby impeding the cardiac rupture and ventricular remodeling, which eventually prevents AMI progression.

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Section: Discussionmentioning

confidence: 99%

Retracted: IRAK3 gene silencing prevents cardiac rupture and ventricular remodeling through negative regulation of the NF‐κB signaling pathway in a mouse model of acute myocardial infarction

Wang

et al. 2018

Journal Cellular Physiology

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“…A significant correlation was previously found between NT-proBNP and TAPSE in 60 patients with chronic heart failure ( 43 ). Furthermore, Nakano et al observed a significant positive correlation between TAPSE and cardiac index in patients ( 44 ).…”

Section: Discussionmentioning

confidence: 97%

Benefits of a Supervised Ambulatory Outpatient Program in a Cardiovascular Rehabilitation Unit Prior to a Heart Transplant: A Case Study

Poty

Krim²,

Lopes

et al. 2022

Front. Cardiovasc. Med.

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Preoperative peak oxygen uptake (V.O2peak) and ventilatory efficiency (V.E/V.CO2slope) are related to the vital prognosis after cardiac transplantation (HTx). The objective of our study was to evaluate the effects of exercise-based cardiac rehabilitation (ECR) program on the preoperative exercise capacity of a HTx candidate. A male patient, aged 50–55 years, with chronic heart failure was placed on the HTx list and performed 12 weeks of intensive ECR (5 sessions-a-week). Our results showed that the cardiac index continuously increased between the onset and the end of ECR (1.40 vs. 2.53 L.min–1.m2). The first 20 sessions of ECR induced a V.O2peak increase (15.0 vs. 19.3 ml.min–1.kg–1, corresponding to 42.0 and 53.0% of its maximal predicted values, respectively). The peak V.O2 plateaued between the 20th and the 40th ECR session (19.3 vs. 19.4 ml.min–1.kg–1) then progressively increased until the 60th ECR session to reach 25.7 ml.min–1.kg–1, i.e., 71.0% of the maximal predicted values. The slope of V.E/V.CO2 showed a biphasic response during the ECR program, with an increase between the onset and the 20th ECR session (58.02 vs. 70.48) and a decrease between the 20th and the 40th ECR session (70.48 vs. 40.94) to reach its minimal value at the 60th ECR session (31.97). After the first 40 sessions of the ECR program, the Seattle Heart Failure Model score predicted median survival time was estimated at 7.2 years. In conclusion, the improvement in exercise capacity and cardiorespiratory function following the ECR helped delay the heart transplant surgery in our patient awaiting heart transplantation.

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“…Several other (pediatric and adult) studies have indicated that echocardiographic parameters for the left side of the heart offer prognostic information on PAH (9,23,24), although most of the previous studies have focused on anatomic and functional variables for the right side of the heart (8,10,17,(25)(26)(27)(28). In a systematic review and meta-analysis of prognostic factors in pediatric PAH, Ploegstra et al identified nine echocardiographic parameters where a single measurement was associated with length of survival in children, all of which were related to the function of the right side of the heart (26).…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic Changes and Long-Term Clinical Outcomes in Pediatric Patients With Pulmonary Arterial Hypertension Treated With Bosentan for 72 Weeks: A Post-hoc Analysis From the FUTURE 3 Study

et al. 2021

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FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion (FUTURE) 3 was a 24-week open-label, prospective, and randomized phase 3 study that assessed the pharmacokinetics of bosentan 2 mg/kg b.i.d. or t.i.d. in children with pulmonary arterial hypertension (PAH). We report findings from a post-hoc analysis that explored the prognostic value of echocardiographic changes during FUTURE 3 in relation to clinical outcomes observed during the 24-week core study and 48-week extension. Patients aged ≥3 months to <12 years (n = 64) received oral doses of bosentan 2 mg/kg b.i.d. or t.i.d. (1:1) for 24 weeks, after which they were eligible to enter the extension with continued bosentan administration. Echocardiographic evaluations were performed at baseline, Week 12, and 24 of the core study via central reading, and analyzed post-hoc for correlation with clinical outcomes (time to PAH worsening, time to death, and vital status). Sixty-four patients were randomized in the core study [median (IQR) age 3.8 (1.7–7.8) years]; and 58 patients (90.6%) entered the 48-week extension. Most of the patients (68.8%) were receiving ≥1 PAH medication at baseline. Echocardiographic changes during the core study were small but with high variability. There were statistically significant associations at Week 24 between worsening of the parameters, systolic left ventricular eccentricity index (LVEIS) and E/A ratio mitral valve flow, and the outcomes of time to death and time to PAH worsening. Additional studies that utilize simple and reproducible echocardiographic assessments are needed to confirm these findings and subsequently identify potential treatment goals in pediatric PAH.

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Left ventricular end-diastolic dimension and septal e′ are predictors of cardiac index at rest, while tricuspid annular plane systolic excursion is a predictor of peak oxygen uptake in patients with pulmonary hypertension

Cited by 8 publications

References 28 publications

Retracted: IRAK3 gene silencing prevents cardiac rupture and ventricular remodeling through negative regulation of the NF‐κB signaling pathway in a mouse model of acute myocardial infarction

Retracted: IRAK3 gene silencing prevents cardiac rupture and ventricular remodeling through negative regulation of the NF‐κB signaling pathway in a mouse model of acute myocardial infarction

Benefits of a Supervised Ambulatory Outpatient Program in a Cardiovascular Rehabilitation Unit Prior to a Heart Transplant: A Case Study

Echocardiographic Changes and Long-Term Clinical Outcomes in Pediatric Patients With Pulmonary Arterial Hypertension Treated With Bosentan for 72 Weeks: A Post-hoc Analysis From the FUTURE 3 Study

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