Left ventricular filling abnormalities in asymptomatic morbid obesity

Zarich, Stuart; Kowalchuk, Glen J.; McGuire, Maureen P.; Benotti, Peter N.; Mascioli, Edward A.; Nesto, Richard W.

doi:10.1016/0002-9149(91)90835-9

Cited by 122 publications

(88 citation statements)

References 24 publications

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“…Left ventricular filling abnormalities have been described in morbid obese patients without symptoms of cardiac failure. 37 This diastolic dysfunction could be considered as a subclinical form of cardiomyopathy in obese individuals. These cardiac abnormalities might also contribute to the dyspnea sensation.…”

Section: Discussionmentioning

confidence: 99%

Physiologic correlates of dyspnea in patients with morbid obesity

et al. 2006

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Objective: Mechanisms of dyspnea in obesity remain unclear. This study was undertaken to determine the relationships between dyspnea and pulmonary function including inspiratory muscle endurance (IME) in morbidly obese patients before bariatric surgery. Research methods and procedures: Fifty-five patients with a mean7s.d. body mass index (BMI) of 49.477.0 kg/m 2 were included. Dyspnea was evaluated by the Baseline Dyspnea Index (BDI; 0-12, 0 ¼ maximal dyspnea). Pulmonary function tests included a plethysmography, maximal inspiratory pressure (PImax) and IME was assessed by the incremental threshold loading test, determining the maximal pressure sustained for 2 min (Plim 2 ) and Plim 2 /PImax ratio. Patients were classified according to their BMI in two groups: BMI p49 (n ¼ 27) and 449 kg/m 2 (n ¼ 28

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Section: Discussionmentioning

confidence: 99%

Physiologic correlates of dyspnea in patients with morbid obesity

et al. 2006

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“…Even in the absence of any apparent complications, obesity may be accompanied by minimal asymptomatic myocardial dysfunction. 26,27 However, co-morbidity factors such as HT and DM may effect ECG values. 28,29 According to the results of the linear regression analyses carried out in the current study, we did not find any association between co-morbidity factors with P-wave and QTc dispersion, which may indicate that these comorbity factors do not have a considerable effect on ECG.…”

Section: Qtc Interval and Dispersionmentioning

confidence: 99%

Effect of obesity on P-wave dispersion and QT dispersion in women

et al. 2006

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Objective: The aim of this study was to investigate the effect of obesity on dispersion of P-wave duration and QTc interval in obese women. Methods: Forty-two obese women (Body mass index (BMI) ¼ 4073 kg/m 2 , mean age 4579 years) and compared agematched (BMI ¼ 2271 kg/m 2 , mean age 4176 years) twenty-five non-obese women were included in our study. Maximum and minimum P-wave duration, P-wave dispersion (difference between the maximum and the minimum P-wave duration), maximum and minimum QTc interval, and QTc dispersion (the difference between the maximum and the minimum QTc interval) were measured from 12-lead ECG. ECG's were transferred to a personal computer via a scanner and then used for magnification of 400 times by Adobe Photoshop software. Results: There was significant difference in BMI (4073 vs 2271 kg/m 2 , Po0.001, respectively) between obese and non-obese women. Obese women had higher Max. P-wave duration (116711 vs 94714 ms, Po0.001), P-wave dispersion (51715 vs 26711 ms, Po0.001), Max. QTc interval (449738 vs 419730 ms, Po0.001) and QTc dispersion (57723 vs 38715 ms, Po0.001) compared to non-obese women. A significant correlation was found between BMI and Max. P-wave duration (r ¼ 0.584, Po0.001), P-wave dispersion (r ¼ 0.621, Po0.001), Max. QTc interval (r ¼ 0.410, Po0.001), and QTc dispersion (r ¼ 0.429, Po0.001). In the linear regression analysis, compared to co-morbidity factors such as age, hypertension, diabetes mellitus and smoking, there was significant association between only BMI and electrocardiographic values (P-wave and QTc dispersion). Conclusion: We concluded that obesity caused significant increase in P-wave and QTc dispersion. Therefore, obese women may not only be under the risk of ventricular arrhythmias, but also they may under the risk of atrial arrhythmias.

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“…Similarly, Hei et al followed up 13000 adults for an average of 19 years to investigate the relationship between obesity and heart failure, and reported a close association; however, the association between the obesity and the le ventricular function was not examined [8]. e majority of studies performed on discrete patient populations indicate a relationship between the le ventricular diastolic dysfunctions and obesity [9,10,22]. In contrast, there are con icting reports regarding the association between the obesity and the le ventricular systolic dys- diabetes mellitus, dyslipidemi of peak early trans-mitral lli velocity (E') and peak late dias ia, smoking and glucose levels ing velocity (E) and peak late t stolic velocity (A') .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, several studies show a relationship between increased body mass and the development of heart failure [7,8]. Adverse e ects of overweight and obesity on the le ventricular systolic and diastolic functions are shown in prede ned populations [9][10][11][12]. e severity of the deterioration in the le ventricular systolic and diastolic functions a er acute myocardial infarction (AMI) has been revealed to be strongly associated with a poor prognosis [13].…”

mentioning

confidence: 99%

Effect of overweight and obesity on the left ventricular systolic and diastolic functions in patients with acute myocardial infarction

Poyraz¹,

Turfan²,

Kocaman³

et al. 2012

CIM

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E ect of overweight and obesity on the le ventricular systolic and diastolic functions in patients with acute myocardial infarction AbstractPurpose: e purpose of this study was to evaluate whether a association exits among overweight and obesity and le ventricular systolic and diastolic functions in patients admitted with rst ST-elevation myocardial infarction (STEMI).Methods: e present study was performed on 451 consecutive patients diagnosed with rst STEMI (376 men, 75 women; mean age 56.1±10.8 years). e patients were classi ed into three groups based on their body mass index (BMI) as normal weight (BMI < 25 kg/ m2), overweight (BMI: 25-29.9 kg/m2) and obese (BMI>30 kg/m2). Echocardiographic features were evaluated and compared among the three groups.Results: Mitral annulus E velocities were higher in obese individuals than normal weight group (p <0.01). In contrast, mitral A velocities were lower (p =0.03); consequently, E\A and E'\A' ratios were lower (both p =0.01) in the obese group with respect to normal weight group. When the correction of entire variations existing among the groups were performed using multivariate linear regressions analyses, it turned out that BMI was independently associated with E/A (β= -0.19, p =0.044) and with E'/A' (β= -0.016, p=0.021). Ejection fraction, wall motion score index and myocardial S velocities were comparable among the study groups (p >0.05).Conclusion: ese results suggest that while obesity has no adverse e ect on the le ventricular systolic function, it has unfavorable consequences on the le ventricular diastolic function in the patients with rst STEMI. In contrast, no unfavorable e ects of overweight on the le ventricular systolic and diastolic function were detected.

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Left ventricular filling abnormalities in asymptomatic morbid obesity

Cited by 122 publications

References 24 publications

Physiologic correlates of dyspnea in patients with morbid obesity

Physiologic correlates of dyspnea in patients with morbid obesity

Effect of obesity on P-wave dispersion and QT dispersion in women

Effect of overweight and obesity on the left ventricular systolic and diastolic functions in patients with acute myocardial infarction

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