Left ventricular filling patterns and its relation to left ventricular untwist in patients with type 1 diabetes and normal ejection fraction

Shivu, Ganesh Nallur; Abozguia, Khalid; Phan, Thanh; Narendran, Parth; Stevens, Martin J.; Frenneaux, Michael

doi:10.1016/j.ijcard.2011.12.051

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…Preserved LV ejection fraction, despite decreased LV mechanics, could be explained with increased LV torsion in diabetic patients that we found in our investigation. This hypothesis is supported by recently published studies . Namely, Shivu et al .…”

Section: Discussionsupporting

confidence: 81%

“…This hypothesis is supported by recently published studies . Namely, Shivu et al . showed that LV torsion was increased in the young patients with uncomplicated type 1 DM.…”

Section: Discussionsupporting

confidence: 76%

“…This hypothesis is supported by recently published studies. 26,27 Namely, Shivu et al 26,27 showed that LV torsion was increased in the young patients with uncomplicated type 1 DM. The authors also revealed that LV untwisting rate in early diastole was preserved, whereas untwisting rate during late diastole was increased and delayed.…”

Section: Discussionmentioning

confidence: 99%

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Left Ventricular Mechanics in Untreated Normotensive Patients with Type 2 Diabetes Mellitus: A Two‐ and Three‐dimensional Speckle Tracking Study

et al. 2014

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Section: Discussionsupporting

confidence: 81%

“…This hypothesis is supported by recently published studies . Namely, Shivu et al . showed that LV torsion was increased in the young patients with uncomplicated type 1 DM.…”

Section: Discussionsupporting

confidence: 76%

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Left Ventricular Mechanics in Untreated Normotensive Patients with Type 2 Diabetes Mellitus: A Two‐ and Three‐dimensional Speckle Tracking Study

et al. 2014

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“…Previous reports based on tissue Doppler imaging, two-dimensional speckle-tracking echocardiography, or MRI found either preserved or increased twist and torsion in adults with diabetic cardiomyopathy. [23][24][25] A three-dimensional speckle-tracking echocardiography study in children with type 1 diabetes mellitus showed preserved twist and torsion, but their patients are younger, and diabetes duration is shorter than our patients. 22 We did not find a significant correlation between the left ventricular strain parameters and serum glycosylated haemoglobin levels or type 1 diabetes mellitus duration.…”

Section: Discussioncontrasting

confidence: 45%

Evaluation of the left ventricular systolic function and myocardial deformation by real-time three-dimensional (four-dimensional) and speckle-tracking echocardiography in children with type 1 diabetes mellitus

et al. 2022

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Aim: This study aimed to evaluate the role of real-time three-dimensional (known as four-dimensional) echocardiography and three-dimensional speckle-tracking echocardiography for the early detection of left ventricular systolic dysfunction in asymptomatic children with type 1 diabetes mellitus. Materials and method: This cross-sectional study included 38 patients (mean age 15.4 ± 2.9, 42.1% male) and 38 age, gender, and body measurements matched healthy children. Each patient underwent an interview about medical history, a detailed clinical examination, blood laboratory tests, conventional echocardiography, and tissue Doppler imaging. Left ventricular ejection fraction; global longitudinal, circumferential, radial strain; twist; and torsion were measured by real-time three-dimensional and speckle-tracking echocardiography. Results: Conventional echocardiography and tissue Doppler imaging showed normal left ventricular systolic function in the patients. Although left ventricular ejection fraction (61.6 ± 1.4%, 61.8 ± 1.1%, p = 0.386), global longitudinal [−26.6 (−27.7 to −26.1)%, −26.2 (−27.7 to −24.9)%, p = 0.224], and radial strain [44.4 (42.4–45.9)%, 43.9 (41–46.1)%, p = 0.513] were similar to the controls, circumferential strain (−27.3 ± 1.3%, −28.0 ± 1.6%, p = 0.048) and twist (9.5 ± 2.3°, 11.4 ± 3.0°, p = 0.003) were decreased in the patients compared with controls. Conclusion: We found that even in children with asymptomatic type 1 diabetes mellitus with normal left ventricular ejection fraction, circumferential function was impaired and rotation pattern was changed. This novel echocardiographic method might be an important tool for detecting left ventricular systolic dysfunction in type 1 diabetes mellitus children before it becomes overt on conventional echocardiography and tissue Doppler imaging.

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“…Rotational function was unchanged. Previous reports based on TDI, 2D-STE or magnetic resonance imaging also found preserved or increased twist and torsion in diabetic cardiomyopathy ( 29 , 30 ).…”

Section: Discussionmentioning

confidence: 61%

Evolution of subclinical myocardial dysfunction detected by two-dimensional and three-dimensional speckle tracking in asymptomatic type 1 diabetic patients: a long‑term follow-up study

Ringlé¹,

Dornhorst²,

Rehman³

et al. 2017

Echo Res Pract

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BackgroundWe sought to assess the long-term evolution of left ventricular (LV) function using two-dimensional (2D) and three-dimensional (3D) speckle tracking echocardiography (STE) for the detection of preclinical diabetic cardiomyopathy, in asymptomatic type 1 diabetic patients, over a 6-year follow-up.Design and methodsSixty-six asymptomatic type 1 diabetic patients with no cardiovascular risk factors were compared to 26 matched healthy controls. Conventional, 2D and 3D-STE were performed at baseline. A subgroup of 14 patients underwent a 6-year follow-up evaluation.ResultsAt baseline, diabetic patients had similar LV ejection fraction (60 vs 61%; P = NS), but impaired longitudinal function, as assessed by 2D-global longitudinal strain (GLS) (−18.9 ± 2 vs −20.5 ± 2; P = 0.0002) and 3D-GLS (−17.5 ± 2 vs −19 ± 2; P = 0.003). At follow-up, diabetic patients had worsened longitudinal function compared to baseline (2D-GLS: −18.4 ± 1 vs −19.2 ± 1; P = 0.03). Global circumferential (GCS) and radial (GRS) strains were unchanged at baseline and during follow-up. Metabolic status did not correlate with GLS, whereas GCS and GRS showed a good correlation, suggestive of a compensatory increase of circumferential and radial functions in advanced stages of the disease – long-term diabetes (GCS: −26 ± 3 vs −23.3 ± 3; P = 0.008) and in the presence of microvascular complications (GRS: 38.8 ± 9 vs 34.3 ± 8; P = 0.04).ConclusionsSubclinical myocardial dysfunction can be detected by 2D and 3D-STE in type 1 diabetic patients, independently of any other cardiovascular risk factors. Diabetic cardiomyopathy progression was suggested by a mild decrease in longitudinal function at the follow-up, but did not extend to a clinical expression of the disease, as no death or over heart failure was reported.

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Left ventricular filling patterns and its relation to left ventricular untwist in patients with type 1 diabetes and normal ejection fraction

Cited by 5 publications

References 23 publications

Left Ventricular Mechanics in Untreated Normotensive Patients with Type 2 Diabetes Mellitus: A Two‐ and Three‐dimensional Speckle Tracking Study

Left Ventricular Mechanics in Untreated Normotensive Patients with Type 2 Diabetes Mellitus: A Two‐ and Three‐dimensional Speckle Tracking Study

Evaluation of the left ventricular systolic function and myocardial deformation by real-time three-dimensional (four-dimensional) and speckle-tracking echocardiography in children with type 1 diabetes mellitus

Evolution of subclinical myocardial dysfunction detected by two-dimensional and three-dimensional speckle tracking in asymptomatic type 1 diabetic patients: a long‑term follow-up study

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