Left ventricular force-velocity relations measured from quick volume changes

Schiereck, P.; Boom, H.B.K.

doi:10.1007/bf00581429

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…On the other hand, MASON et al (1970) determined the ralation between the isovolumic pressure and the shortening velocity of the wall muscle in human ventricle. SCHIERECK and BOOM (1979) obtained the rabbit left ventricular force-velocity relation by a similar method.…”

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confidence: 99%

Pressure-velocity relation in the isolated rabbit left ventricle.

Okuyama

1983

Jpn.J.Physiol

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The relation between pressure (P) and ejection velocity (J') was determined in the coronary-perfused rabbit left ventricle. The heart was isolated and a thin latex balloon was inserted into the left ventricle. The volume of the ventricle was changed at a constant velocity with a magnetic shaker connected to the balloon at various phases of contraction and the corresponding pressure change was measured. The pressure-velocity relation determined by this isovelocity method was well fitted by a hyperbolic equation, (PEA) (V+B)=B(P0±A), where A and B are constants and P o is the maximum systolic pressure. Using the thick-walled spherical ventricle model, the Hill equation of the ventricular wall muscle with constants a and b was obtained, and Hill constants (a and b) were calculated from ventricular constants (A and B). The constants A and B/V (V is the volume of ventricle) increased with decreases in ventricular volume, but the ratio Vmax/To (=b/aL, L is the length of the muscle) was not affected. The value of vmax/To was 1.14±0.22 x 10_b cm2/(dyn . sec) (mean±S. D. in 9 rabbits). The constants A and B/V, especially A, increased and the ratio vmax/To decreased under the negative inotropic effect, such as decreased heart rate or decreased coronary perfusion pressure. This ratio would therefore be a good indicator for assessment of the ventricular performance as well as the contractility of the wall muscle.

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mentioning

confidence: 99%

Pressure-velocity relation in the isolated rabbit left ventricle.

Okuyama

1983

Jpn.J.Physiol

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Physiological Models Survey

Kerkhof

2018

Wiley Encyclopedia of Electrical and Electronics Engineering

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Basic principles of modeling in the physiological sciences are described, with emphasis on variability as a prerequisite for maintaining a stable system. The level of variability may depend on age, sex, training status, and disease state(s), and also exhibit a diurnal or seasonal pattern. On the other hand, experimental application of perturbation techniques that induce instabilities, may reveal important information about the characteristics of an organ or system, as observed from the details of the concomitant response(s). The Physiome Project offers an integrated approach, including various organ systems of an individual. This worldwide effort of research groups aims to define the physiome via database availability, combined with the development of integrated quantitative and descriptive modeling. The venture is expected to codetermine the future of medicine, change the way we think about human physiology, and strengthen the fabric of international scientific collaboration across nations. A new element concerning regulation is based on the increased awareness of sex‐related differences as observed in anatomy and neurohumoral and immune systems, along with their implications for physiology models.

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