Left ventricular global function index predicts incident heart failure and cardiovascular disease in young adults: the coronary artery risk development in young adults (CARDIA) study

Nwabuo, Chike C.; Moreira, Henrique T.; Vasconcellos, Henrique Doria De; Mewton, Nathan; Opdahl, Anders; Ogunyankin, Kofo O.; Ambale-Venkatesh, Bharath; Schreiner, Pamela J.; Armstrong, Anderson da Costa; Lewis, Cora E.; Jacobs, David R.; Lloyd‐Jones, Donald M.; Gidding, Samuel S.; Lima, João A.C.

doi:10.1093/ehjci/jey123

Cited by 47 publications

(56 citation statements)

References 30 publications

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“…Величина ИГФ ЛЖ в целом по группе наблюдаемых пациентов в возрасте ≥60 лет с ХСН составила 21, 7 (19,3-22,9)%. Эти значения ИГФ ЛЖ оказались существенно меньше при сравнении с данными, полученными другими исследователями у лиц без ССЗ, а также у больных перенесших острый ИМ с последующей реваскуляризацией [2][3][4][5]. Это вполне закономерно, т. к. ремоделирование ЛЖ у больных ХСН выражено в наибольшей степени.…”

Section: Discussionunclassified

“…В исследовании [5] оценивалось прогностическое значение ИГФ ЛЖ по сравнению с ФВ ЛЖ в отношении развития СН и ССЗ у 4107 пациентов без ССЗ, средний возраст которых составил 29,8±3,7 лет. Среди пациентов без развившихся ССС ФВ ЛЖ составила 64,6±7,9%, ИГФ ЛЖ 34,8±6,1%, в отличие от пациентов с развившимися ССС: ФВ ЛЖ -63,4±9,6%, ИГФ ЛЖ -32,4±6,9%, из которых с развившейся СН -ФВ ЛЖ -60,9±11,9%, ИГФ ЛЖ -30,9±8,0%, с развившимися тяжелыми ССС -ФВ ЛЖ -63,3±9,7%, ИГФ ЛЖ -32,2±7,0%.…”

Section: Discussionunclassified

“…ИГФ ЛЖ легко определяется с помощью общепринятого ЭхоКГ исследования, и объединяет информацию о глобальных систолических характеристи-ках ЛЖ с его анатомическими параметрами, имеет широкий ранг значений, коррелирующий с уровнем структурного ремоделирования ЛЖ. Количество больных, у которых не удается адекватно рассчитать ИГФ ЛЖ при 2-мерном ЭхоКГ исследовании, невелико и составляет 3,1% вследствие потерь или неоптимального изображения одного или нескольких параметров ЛЖ на ЭхоКГ [5].…”

Section: Discussionunclassified

“…В представленный в работе фрагмент исследования Кардиоваскулярная терапия и профилактика. 2020;19 (5) ных Американской Ассоциацией эхокардиографии и Европейского общества сердечно-сосудистой визуализации [6,7]. ИГФ ЛЖ (в %) рассчитывался по формуле: Конечно-диастолический размер (КДР, см) определялся как расстояние между левым контуром межжелудочковой перегородки (МЖП) и поверхностью эндокарда задней стенки на уровне зубца R электрокардиограммы (ЭКГ).…”

Section: материал и методыunclassified

“…При этом дополнитель-ная прогностическая ценность ИГФ ЛЖ при сравнении с фракцией выброса (ФВ) ЛЖ была установлена не во всех исследованиях [4]. В 2019г в исследовании CARDIA (The Coronary Ar tery Risk Development in Young Adults) ИГФ ЛЖ впер вые оценивался методом эхокардиографии (ЭхоКГ); была показана его высокая предсказательная ценность в отношении возникновения СН и сердечно-сосудистых заболеваний (ССЗ), а также показана его до полнительная прогностическая значимость по сра внению с ФВ ЛЖ [5].…”

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Left ventricular global function index: prognostic value in patients with heart failure aged 60 years and older

Ларина

Лунев

Алёхин

2020

Cardiovasc Ther Prev

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Left ventricular (LV) global function index (LVGFI) is a novel marker that incorporates the functional and structural characteristics of the LV.Aim. To evaluate the prognostic value of LVGFI in outpatients with heart failure with preserved ejection fraction (HFpEF) aged 60 years and older.Material and methods. The study included 78 patients (male, 42%) aged 74 (67-77) years with NYHA class II-III heart failure. LVGFI was defined as LV stroke volume/LV global volume х 100, where LV global volume was the sum of the LV mean cavity volume ((LV end-diastolic volume + LV end-systolic volume)/2) and myocardial volume (LV mass/ density).Results. The median LVGFI was 21,7% (interquartile range 19,3 to 22,9%). Higher NYHA class of HF was associated with worse LVGFI:class II HF was associated with LVGFI of 22,0 (20,3-23,1)%, class III HF — with 20,4 (17,5-22,4)%. During the 3—month (24-48) follow-up period, 15 (19,2%) patients died. Among patients with NYHA class II HF, 6 out of 61 (9,8%) died, with class III HF — 9 out of 17 (53,0%) (p<0,001). According to ROC analysis, the optimal LVGFI cut-off point for the prediction of an unfavorable prognosis in patients with HFpEF aged 60 years was ≤21,1% (p<0,001). The sensitivity was 73,3%, specificity — 70,0%. Patients with LVGFI ≤21,1% had significantly lower survival: among patients with LVGFI ≤21,1%, 11 out of 30 (36,7%) died; among those with LVGFI >21,1%, 4 out of 48 (8,3 %) died (p=0,016).Conclusion. Higher NYHA class of HF was associated with worse LVGFI. Patients with lower LVGFI have significantly lower survival. The optimal LVGFI cut-off point for the prediction of an unfavorable prognosis in patients with HFrEF aged 60 years was <21,1%.

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Left ventricular global function index: prognostic value in patients with heart failure aged 60 years and older

Ларина

Лунев

Алёхин

2020

Cardiovasc Ther Prev

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Association Between Visit-to-Visit Blood Pressure Variability in Early Adulthood and Myocardial Structure and Function in Later Life

et al. 2020

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IMPORTANCE Long-term blood pressure (BP) variability has emerged as a reproducible measure that is associated with heart failure independent of systemic BP. Visit-to-visit BP variability may be associated with the risk of heart failure early in the life course and thus may be reflected in subclinical alterations in cardiac structure and function.OBJECTIVE To evaluate the association between visit-to-visit BP variability in early adulthood and myocardial structure and function in middle age. DESIGN, SETTING, AND PARTICIPANTSThis cohort study used data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a community-based cohort study of 5115 participants aged 18 to 30 years at baseline (year 0; March 25, 1985, to June 7, 1986 and followed up over a 30-year interval. A total of 2400 CARDIA study participants underwent evaluation at 4 field sites

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Coffee and tea consumption in the early adult lifespan and left ventricular function in middle age: the CARDIA study

et al. 2020

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Aims The long-term impact of coffee or tea consumption on subclinical left ventricular (LV) systolic or diastolic function has not been previously studied. We examined the association between coffee or tea consumption beginning in early adulthood and cardiac function in midlife. Methods and results We investigated 2735 Coronary Artery Risk Development in Young Adults (CARDIA) study participants with long-term total caffeine intake, coffee, and tea consumption data from three visits over a 20 year interval and available echocardiography indices at the CARDIA Year-25 exam (2010-2011). Linear regression models were used to assess the association between caffeine intake, tea, and coffee consumption (independent variables) and echocardiography outcomes [LV mass, left atrial volume, and global longitudinal strain (GLS), LV ejection fraction (LVEF), and transmitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity (E/e´)]. Models were adjusted for standard cardiovascular risk factors, socioeconomic status, physical activity, alcohol use, and dietary factors (calorie intake, whole and refined grain intake, and fruit and vegetable consumption). Mean (standard deviation) age was 25.2 (3.5) years at the CARDIA Year-0 exam (1985-1986), 57.4% were women, and 41.9% were African-American. In adjusted multivariable linear regression models assessing the relationship between coffee consumption and GLS, beta coefficients when comparing coffee drinkers of <1, 1-2, 3-4, and >4 cups/day with non-coffee drinkers were β = À0.30%, P < 0.05; β = À0.35%, P < 0.05; β = À0.32%, P < 0.05; β = À0.40%, P > 0.05; respectively (more negative values implies better systolic function). In adjusted multivariable linear regression models assessing the relationship between coffee consumption and E/e´, beta coefficients when comparing coffee drinkers of <1, 1-2, 3-4, and >4 cups/day with non-coffee drinkers were β = À0.29, P < 0.05; β = À0.38, P < 0.01; β = À0.20, P > .05; and β = À0.37, P > 0.05, respectively (more negative values implies better diastolic function). High daily coffee consumption (>4 cups/day) was associated with worse LVEF (β = À1.69, P < 0.05). There were no associations between either tea drinking or total caffeine intake and cardiac function (P > 0.05 for all). Conclusions Low-to-moderate daily coffee consumption from early adulthood to middle age was associated with better LV systolic and diastolic function in midlife. High daily coffee consumption (>4cups/day) was associated with worse LV function. There was no association between caffeine or tea intake and cardiac function.

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Left ventricular global function index predicts incident heart failure and cardiovascular disease in young adults: the coronary artery risk development in young adults (CARDIA) study

Abstract: LVGFI is a strong, independent predictor of incident HF and CVD that provides incremental prognostic value compared with LVEF. Male sex, black race, obesity, hypertension, and smoking are associated with worse LVGFI in the early adult lifespan.

Cited by 47 publications

References 30 publications

Left ventricular global function index: prognostic value in patients with heart failure aged 60 years and older

Left ventricular global function index: prognostic value in patients with heart failure aged 60 years and older

Association Between Visit-to-Visit Blood Pressure Variability in Early Adulthood and Myocardial Structure and Function in Later Life

Coffee and tea consumption in the early adult lifespan and left ventricular function in middle age: the CARDIA study

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