Left Ventricular Hypertrophy and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis

Abstract

Background and Purpose Left ventricular hypertrophy (LVH) is associated with the risk of stroke and dementia independently of other vascular risk factors, but its association with cerebral small vessel disease (CSVD) remains unknown. Here, we employed a systematic review and meta-analysis to address this gap.<br/>Methods Following the MOOSE guidelines (PROSPERO protocol: CRD42018110305), we systematically searched the literature for studies exploring the association between LVH or left ventricular (LV) mass, with neuroimaging markers of CSVD (lacunes, white matter hyperintensities [WMHs], cerebral microbleeds [CMBs]). We evaluated risk of bias and pooled association estimates with random-effects meta-analyses.<br/>Results We identified 31 studies (n=25,562) meeting our eligibility criteria. In meta-analysis, LVH was associated with lacunes and extensive WMHs in studies of the general population (odds ratio [OR]lacunes, 1.49; 95% confidence interval [CI], 1.12 to 2.00) (ORWMH, 1.73; 95% CI, 1.38 to 2.17) and studies in highrisk populations (ORlacunes: 2.39; 95% CI, 1.32 to 4.32) (ORWMH, 2.01; 95% CI, 1.45 to 2.80). The results remained stable in general population studies adjusting for hypertension and other vascular risk factors, as well as in sub-analyses by LVH assessment method (echocardiography/electrocardiogram), study design (cross-sectional/cohort), and study quality. Across LV morphology patterns, we found gradually increasing ORs for concentric remodelling, eccentric hypertrophy, and concentric hypertrophy, as compared to normal LV geometry. LVH was further associated with CMBs in high-risk population studies.<br/>Conclusions LVH is associated with neuroimaging markers of CSVD independently of hypertension and other vascular risk factors. Our findings suggest LVH as a novel risk factor for CSVD and highlight the link between subclinical heart and brain damage.

[Retracted] Meta‐Analysis of the Relationship between the Prognosis of Acute Cerebral Infarction Intravenous Lysis and Cerebral Microbleeds Based on Intelligent Medical Care

“…The meta-analysis based on intelligent medicine can effectively analyze the relevant factors of medical problems, and the relationship between ACI intravenous thrombolysis and cerebral microbleeds is studied through the meta-analysis of intelligent medicine. Among them, Papadopoulos A. used meta-analysis of ACI intravenous thrombolysis and cerebral microbleeds and judged the influencing factors by comparative odds ratio [ 6 ]. Tomohiro et al used intelligent medical technology to analyze the related factors of the prognosis of ACI intravenous thrombolysis and determined the influencing factors through the meta-analysis of related factors and cerebral microbleeds [ 7 ].…”

Improving detection of cerebral small vessel disease aetiology in patients with isolated lobar intracerebral haemorrhage

“…The presence of LVH (an imaging marker for hypertensive end-organ damage11 and hence HTN-cSVD2 8 12 13) was determined by screening transthoracic echocardiography reports within 1 year of the event. LVH was defined according to the American Society of Echocardiography guidelines using left ventricular mass indexed to body surface area (with a left ventricular mass index cut-off of >95 g/m 2 for women and >115 g/m 2 for men) 14.…”

Neurofilament Light: a biomarker of neurodegeneration correlated with Type 2 diabetes and other related diseases

“…Left ventricular hypertrophy (LVH) is highly prevalent in patients with T2D [70,71], and independently associated with cognitive impairment, dementia and cardiovascular (CV) events [72][73][74]. Recently, Patel et al [75] investigate the relationship between LVH, NfL levels and brain atrophy in people with T2D.…”