Left ventricular hypertrophy and diastolic function in children and adolescents with essential hypertension

Lee, Heirim; Kong, Younghwa; Kim, Kyung‐Hee; Huh, June; Kang, I-Seok; Song, Jisoo

doi:10.1186/s40885-015-0031-8

Cited by 25 publications

(26 citation statements)

References 19 publications

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“…Indexation by height 2.7 may be considered a more suitable approach to scaling LVM for body size in recent years, especially in obese and overweight hypertensive patients, to some extent independently from the cut-off settled. Considering the presence of a significative difference in BMI between the three groups in our study, we indexed LVM by height 2.7 to classify LV geometry in order to minimize the interference of obesity [ 19 – 21 ]. Impaired LV diastolic dysfunction happened earlier than systolic dysfunction and was followed by a decrease in early-diastolic ventricular filling and a greater atrial contribution to ventricular filling in the late-systolic period [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Geometrical and functional changes of left heart in adults with prehypertension and hypertension: a cross-sectional study from China

Guo

Chen

et al. 2016

BMC Cardiovasc Disord

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BackgroundStudies regarding the association between prehypertension and the structual changes of left heart are scanty. However, which type of the geometrical change of left heart is predominated one in prehypertension and hypertension is controversial. It is therefore important to investigate geometrical and functional changes of left heart in adults with prehypertension and hypertension because of their prognostic significance.MethodsThe study was based on a cross-sectional design, a total of 10547 participants were classified into normotension group, prehypertension group and hypertension group. We analyzed clinical characteristics, echocardiographic parameters and distribution of left ventricular (LV) geometrical patterns in different groups.ResultsParticipants with prehypertension had higher values of most of echocardiographic parameters than those with normotension. The prevalence of left ventricular hypertrophy(LVH) was statistically different among three groups (P <0.001), and the rates of LVH in the three groups were 5.9, 8.6, 28.4 % by indexation to height2.7 and 4.9, 5.3, 19.3 % by indexation to BSA, respectively. The prevalence rates of eccentric hypertrophy, concentric remodeling and concentric hypertrophy were 7.3 %, 5.3 % and 1.4 % in prehypertension group, and 17.8 %, 8.8 % and 10.6 % in hypertension group. Logistic regression analysis showed that systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean artery pressure (MAP) were all independent risk factors for left cardiac structural changes, and pulse pressure (PP) was independent risk factor for concentric and eccentric hypertrophy. Among four indices, DBP levels with OR values of 1.192, 1.759 and 1.278 were the strongest indicator for concentric remodeling, concentric hypertrophy and eccentric hypertrophy, respectively (P <0.001).ConclusionsThere exists LV geometrical change in adults with prehypertension and hypertension in rural Chinese population, and the eccentric hypertrophy was the highest proportion of geometric alterations. SBP, DBP, MAP and PP were all positively associated with left cardiac structural changes, and the association of DBP was the strongest.

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Section: Discussionmentioning

confidence: 99%

Geometrical and functional changes of left heart in adults with prehypertension and hypertension: a cross-sectional study from China

Guo

Chen

et al. 2016

BMC Cardiovasc Disord

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“…[ 31 , 48 , 49 ] Also, LVM index significantly correlated with BMI in children and adolescents with essential hypertension. [ 50 , 51 ] In our study, WC above the 90th percentile is a predictive factor for increased LVM index and concentric hypertrophy in both children and adolescents. Moreover, concentric remodeling and the presence of eccentric hypertrophy were not significantly influenced by the presence of visceral obesity.…”

Section: Discussionmentioning

confidence: 50%

Waist circumference a clinical criterion for prediction of cardio-vascular complications in children and adolescences with overweight and obesity

et al. 2020

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Overweight and obesity in childhood are associated with early cardiovascular dysfunction and promote heightened risk of cardiovascular morbidity and mortality in adulthood. Waist circumference (WC) correlates with visceral obesity, which is why obese children with elevated WC need to be carefully monitored to prevent long-term cardio-metabolic complications. The purpose of our study was to establish if WC could be a predictor of cardiovascular complications in children. The authors conducted a retrospective study that included 160 overweight and obese children and adolescents, aged 6 to 18 years. Patients were evaluated completely anthropometrically, biologically, and imagistic. The anthropometric data tracked were height, weight, WC, and body mass index. Echocardiography evaluated the following parameters: the interventricular septum, left ventricular mass, the relative thickness of the ventricular wall, the pathological epicardial fat. Our results confirm that the presence of visceral obesity was significantly associated (χ 2 = 11.72, P = .0006) with pathological epicardial fat. In children, visceral obesity is not a risk factor for vascular or cardiac impairment, but in adolescents, the results showed that visceral obesity is an important predictive factor for the occurrence of vascular (AUC = 0.669, P = .021) and cardiac (AUC = 0.697, P = .037) impairment. Concentric left ventricular (LV) hypertrophy is significantly influenced by the presence of visceral obesity (AUC = 0.664, P = .013 children; AUC = 0.716, P = .026 adolescents). WC above the 90th percentile is a predictive factor for increased LVM index and concentric hypertrophy in both children and adolescents.

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“…We also try to explore the potential correlation between NLR and target organ damage of heart in these hypertension children. As known, LVH and LV diastolic dysfunction are both the early complication of hypertension [41], and there were 5 children had LVH and 1 children had diastolic dysfunction in the hypertension group. Interestingly, we found NLR positively correlated with E/E' ratio among hypertension children.…”

Section: Discussionmentioning

confidence: 88%

Neutrophil to Lymphocyte Ratio is Increased and Associated with Left Ventricular Diastolic Function in Newly Diagnosed Essential Hypertension Children.

Miao

Cao

Ding

et al. 2020

Preprint

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Aim Hypertension is associated with cardiac structural and functional changes, including left ventricular hypertrophy (LVH), LV systolic dysfunction, and diastolic dysfunction. Neutrophil to lymphocyte ratio (NLR) is a novel inflammatory biomarker associated with cardiovascular diseases. The current study aimed to evaluate NLR in children with newly diagnosed essential hypertension and its relationship between blood pressure and cardiac changes. Methods and subjects 44 children with newly diagnosed essential hypertension and 43 healthy children were included. Clinical characteristics, blood cell counts and biochemical parameters were collected. LVH was assessed by calculation of LV mass index (LVMI), and LV systolic function was evaluated by measuring LV ejection fraction and fractional shortening. LV diastolic function was primarily assessed with E/E’ ratio by doppler and echocardiography. Results The hypertension children had significantly higher LVMI and E/E’ ratio compared to the controls, whereas there was no difference in LV systolic function between two groups. The NLR was significantly higher in the hypertension group than the control group. Moreover, NLR and it was positively correlated with SBP and DBP levels in the hypertension group. Additionally, a significantly positive correlation between NLR and E/E’ ratio was found in the hypertension group. However, NLR was not related to LVH and LV systolic function indicators in hypertension children.Conclusion The higher NLR may be a potential indicator of increased risk for the development of hypertension in children. Moreover, NLR may help to assess the presence of LV diastolic dysfunction in hypertension children.

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Left ventricular hypertrophy and diastolic function in children and adolescents with essential hypertension

Cited by 25 publications

References 19 publications

Geometrical and functional changes of left heart in adults with prehypertension and hypertension: a cross-sectional study from China

Geometrical and functional changes of left heart in adults with prehypertension and hypertension: a cross-sectional study from China

Waist circumference a clinical criterion for prediction of cardio-vascular complications in children and adolescences with overweight and obesity

Neutrophil to Lymphocyte Ratio is Increased and Associated with Left Ventricular Diastolic Function in Newly Diagnosed Essential Hypertension Children.

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