Left ventricular hypertrophy and mortality after aortic valve replacement for aortic stenosis

Abstract

We conclude that excessive ventricular hypertrophy, manifested as a markedly increased relative wall thickness, is associated with a significantly increased risk of postoperative mortality after aortic valve replacement for aortic stenosis.

Aortic stenosis. Gender influence on left ventricular geometry and function in patients under 70 years of age

“…In addition, LVH is associated with increased cardiovascular risk and greater mortality in hypertensive patients 14 . Bad results were observed in women with AS after aortic valve replacement 15 , especially in those with greater RDT and smaller ventricular dimensions 16 . According to Orsinelli et al 16 , women with AS and RDT >0.66 who had undergone aortic valve replacement had operative mortality of 63% versus 14% of those with RDT <0.66.…”

“…Bad results were observed in women with AS after aortic valve replacement 15 , especially in those with greater RDT and smaller ventricular dimensions 16 . According to Orsinelli et al 16 , women with AS and RDT >0.66 who had undergone aortic valve replacement had operative mortality of 63% versus 14% of those with RDT <0.66. Analyzing operative mortality of the patients in our study reveals that women's mortality was significantly higher than that of men (4 deaths among women and none among men, p=0.033).…”

Clinical approach to severe aortic stenosis with low flow and low gradient

“…[5,24,32] Düşük akımlı, korunmuş EF'ye sahip hastalarda, restriktif fizyoloji ve kardiyak debi düşüklüğü nedeniyle, ameliyat sırası mortalite yüksek olmasına rağmen, cerrahi tedavi seçildiğinde beklenen sağkalım oranı, medikal tedavi ile izlenen hasta grubuna göre çok daha iyidir. [7,25,33,34] Hachicha ve ark., [7] retrospektif olarak 25±19 ay takip edilmiş 171 hastayı incelediklerinde, iki yıllık sağkalım oranlarını AKR yapılanlarda %93±3, medikal tedavi tercih edilenlerde %65±7, üç yıllık sağ-kalım oranlarını ise AKR yapılan grupta %93±3, medikal tedavi tercih edilenlerde %58±8 olarak saptamışlar-dır. Her iki grup arasındaki fark, istatistiksel olarak yaş ve cinsiyetten bağımsız bulunmuştur.…”

New concepts in valvular hemodynamics: Implications for diagnosis and treatment of aortic stenosis

“…Concomitance of AS and hypertension: A double load for the left ventricle LV pressure overload caused by AS or systemic arterial hypertension generally results in LV concentric hypertrophy, which has been shown to be a strong independent risk factor for morbidity and mortality (32,33). When AS coexists with hypertension, the LV thus faces a double pressure overload and it is possible that both factors add up to adversely affect LV function and patient outcome.…”