Left ventricular hypertrophy in non-rheumatic myocarditis in children.

Oda, Toshiyuki; Hamamoto, Kunihiro; Morinaga, Hidenobu

doi:10.1253/jcj.46.1235

Cited by 11 publications

(6 citation statements)

References 8 publications

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“…Tc-99m-human serum albumin (HSA) 555-740 MBq (15)(16)(17)(18)(19)(20), was injected into the right antecubital vein at an LAO 45° projection, and cardiac output (CO) at the time of the first pass, and left and right ventricular ejection fractions (LVEF, RVEF) at equilibrium, were analyzed by means of the abovementioned computer system.…”

Section: ) Gated Cardiac Blood Pool Scintigraphymentioning

confidence: 99%

Evaluation of viral myocarditis in children by radionuclide method

et al. 1990

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Evaluation of viral myocarditis is essential for the clinician to assess the prognosis. In this study, Tl-201 myocardial scintigraphy and Tc-99m gated cardiac blood pool scan were performed in 16 patients with myocarditis diagnosed by clinical symptoms and laboratory findings and these nuclear medicine techniques were followed up for 5 years. Exercise Tl-201 scintigraphy using a bicycle ergometer was performed in 8 patients by SPECT imaging. There were mild to severe persistent defects found in all cases (100%), but pressure rate products showed normal response. The Tl-201 defect ratio improved gradually, but did not change significantly. In the resting Tl-201 image one of 16 patients showed severe multifocal defects. LVEF increased significantly from 1 year to 5 years after onset, while RVEF measured by gated blood pool scans showed slight increases 3 years to 5 years after diagnosis. It was concluded that myocardial perfusion improved only incompletely. Cardiac function (LVEF and RVEF) improved gradually, and pressure rate products were normal. Myocarditis should therefore be followed up in order to assess the prognosis; moreover, the relationship of myocarditis to dilated cardiomyopathy needs to be further studied.

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Section: ) Gated Cardiac Blood Pool Scintigraphymentioning

confidence: 99%

Evaluation of viral myocarditis in children by radionuclide method

et al. 1990

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“…In a recent large study on HIV-infected children, Rivenes et al [19] found sensitivities of\20% at specificity levels of 88% to 92%. On the other hand, in a number of smaller studies on patients with a specific cardiac disease, the performance of the pediatric ECG was found to be higher [7,10,12,16,21]. For example, in a group of 19 aortic stenosis patients and 21 normals, Fogel et al [7] found a sensitivity of 67% at 95% specificity.…”

Section: Introductionmentioning

confidence: 97%

Electrocardiographic criteria for left ventricular hypertrophy in children

Herpen

Witsenburg

Kors

2006

Journal of Electrocardiology

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Previous studies to determine the sensitivity of the electrocardiogram (ECG) for left ventricular hypertrophy (LVH) in children had their imperfections: they were not done on an unselected hospital population, several criteria used in adults were not applied to children, and obsolete limits of normal for the ECG parameters were used. Furthermore, left ventricular mass (LVM) was taken as the reference standard for LVH, with no regard for other clinical evidence. The study population consisted of 832 children from whom a 12-lead ECG and an M-mode echocardiogram were taken on the same day. The validity of the ECG criteria was judged on the basis of an abnormal LVM index, either alone or in combination with other clinical evidence. The ECG criteria were based on recently established age-dependent normal limits. At 95% specificity, the ECG criteria have low sensitivities (\25%) when an elevated LVM index is taken as the reference for LVH. When clinical evidence is also taken into account, the sensitivity improved considerably (\43%). Sensitivities could be further improved when ECG parameters were combined. The sensitivity of the pediatric ECG in detecting LVH is low but depends strongly on the definition of the reference used for validation.

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“…The discordance between ECG criteria and TTE-LVH has been described in several pediatric disease states, such as rheumatic heart disease [9], myocarditis [29] and hypertrophic cardiomyopathy [10,30,31].…”

Section: Manuscript To Be Reviewedmentioning

confidence: 99%

Peer Review #3 of "ECG is an inefficient screening-tool for left ventricular hypertrophy in normotensive African children population (v0.1)"

Scarpa¹

2016

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Left ventricular hypertrophy (LVH) is a marker of pediatric hypertension and predicts development of cardiovascular events. Electrocardiography (ECG) screening is used in pediatrics to detect LVH thanks to major accessibility, reproducibility and easy to use compared to transthoracic echocardiography (TTE), that remains the standard technique. Several diseases were previously investigated, but no data exists regarding our study population. Aim of our study was to evaluate the relationship between electrocardiographic and echocardiographic criteria of LVH in normotensive African children. Methods: We studied 313 children (mean age 7,8±3 yo), in north-Madagascar. They underwent ECG and TTE. Sokolow-Lyon index was calculated to identify ECG-LVH (>35 mm). Left ventricle mass (LVM) with TTE was calculated and indexed by height 2.7 (LVMI 2.7) and weight (LVMI w). We report the prevalence of TTE-LVH using three methods: 1) calculating percentiles age-and sex-specific with values >95 th percentile identifying LVH; 2) LVMI 2.7 >51 g/m 2.7 ; 3) LVMI w >3.4 g/weight. Results: 40 (13%) children showed LVMI values >95 th percentile, 24 children (8%) an LVMI 2.7 >51 g/m 2.7 while 19 children (6%) an LVMI w >3.4 g/kg. LVH-ECG by Sokolow-Lyon index was present in 5, 3 and 3 children respectively, with poor values of sensitivity (ranging from 13 to 16%), positive predictive value (from 11 to 18%) and high values of specificity (up to 92%). Effects of anthropometrics parameters on Sokolow-Lyon were analyzed and showed poor correlation. Conclusion: ECG is a poor screening test for detecting LVH in children. In clinical practice, TTE remains the only tool to be used to exclude LVH.

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Left ventricular hypertrophy in non-rheumatic myocarditis in children.

Cited by 11 publications

References 8 publications

Evaluation of viral myocarditis in children by radionuclide method

Evaluation of viral myocarditis in children by radionuclide method

Electrocardiographic criteria for left ventricular hypertrophy in children

Peer Review #3 of "ECG is an inefficient screening-tool for left ventricular hypertrophy in normotensive African children population (v0.1)"

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