Left ventricular hypertrophy in the dialysed patient. What can be done about it?

Cannella, Giuseppe

doi:10.1093/oxfordjournals.ndt.a027303

Cited by 8 publications

(1 citation statement)

References 15 publications

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“…Incidence of cardial death is 10 -20 times higher in these patients than in general population of the same age (3). Hypertrophy of left ventricle is esspecially related to high mortality rate of uraemic patients (4) and is considered as an independent risk factor.…”

Section: Introductionmentioning

confidence: 99%

The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients

Rašić

Kulenović²,

Zulić

et al. 2003

Bosn J of Basic Med Sci

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Anaemia appears to play an important role in left ventricular (LV) enlargement in chronic kidney disease patients. The objective of this study was to evaluate LV echocardiography changes during anaemia correction with recombinant human erythropoietin (rHu-Epo) in chronic haemodialysis patients (HD pts) with signs of anaemia and LV hypertrophy (LVH). The study included 20 HD pts aged 39,6 +/- 5,3 yrs, with the same condition of HD treatment, anaemia and echocardiographically LVH verified. At the beginning of the rHu-Epo treatment haemoglobin (Hb) level was < 90 g/L and the target Hb level was 110 g/L. Echocardiography was performed at the beginning (baseline) and after six months of rHu-Epo treatment. LVH was defined as LV mass index >100 g/m2 in women and >131 g/m2 in men. We observed significant reduction of LV mass index (LVMI) (mean 26,4%, p=0.008), as well as LV volumen. There was a significant negative correlation between Hb level and LVMI with predictive LVMI reduction of 2,317 g/m2 for each 1g/L rising of mean Hb level. The results of the study confirm the importance of early anaemia correction in haemodialysis patients aimed to improve LV parameters.

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Section: Introductionmentioning

confidence: 99%

The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients

Rašić

Kulenović²,

Zulić

et al. 2003

Bosn J of Basic Med Sci

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Cardiac function and structure in patients with chronic renal failure

Schärer

Schmidt

Soergel

1999

Pediatric Nephrology

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The long-term consequences of cardiac alterations in children with chronic renal failure (CRF) and after renal transplantation (TX) are largely unknown. Studies in adults with end-stage renal disease (ESRD) assume that the fate of many pediatric patients is determined by a high cardiovascular morbidity and mortality. This review describes clinical manifestations, pathophysiology, cardiac function and structure, and management of heart disease in children with CRF and post transplant. Echocardiography and Doppler ultrasonography allow differentiation of three functional disturbances: hypercirculation, systolic left ventricular (LV) dysfunction, and diastolic LV dysfunction, in addition to analysis of LV size and myocardial mass. From adult studies LV hypertrophy is recognized as an early prognostic marker of cardiovascular disease. It is present in about half of children with ESRD and after TX. It may regress, at least in part, by control of hypertension, hypervolemia, and anemia. Experimental studies have shown that, independent of these hemodynamic complications, uremia is associated with structural abnormalities of the heart, which were also described in adult patients with ESRD. These lesions consist mainly of hypertrophy of cardiomyocytes, interstitial fibrosis, and vascular changes (rarefied capillaries, thickened arteriolar walls). Cardiac complications in children with CRF and after TX deserve regular clinical and echocardiographic monitoring in order to minimize later cardiovascular morbidity by appropriate treatment.

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Disorders of left ventricular structure and function in chronic uremia: how often, why and what to do with it?

Dyadyk¹,

Bagriy²,

Yarovaya³

1999

European J of Heart Fail

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Ž .Left ventricular LV structure and function abnormalities are frequent in individuals with chronic uraemia; these disorders are at increased risk of cardiovascular and overall morbidity and mortality in the pre-dialyzed population, during dialysis treatment and in renal transplant recipients. This review will attempt to summarize current knowledge of the prevalence, pathophysiological mechanisms of LV disease in chronic uraemia and to discuss useful medical strategies in this population.

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Left ventricular hypertrophy in the dialysed patient. What can be done about it?

Cited by 8 publications

References 15 publications

The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients

The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients

Cardiac function and structure in patients with chronic renal failure

Disorders of left ventricular structure and function in chronic uremia: how often, why and what to do with it?

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