Left ventricular hypertrophy on long-term cardiovascular outcomes in patients with ST-elevation myocardial infarction

Park, Jin-Sun; Shin, Jeong-Sook; Lee, You-Hong; Seo, Kyoung‐Woo; Choi, Byoung‐Joo; Choi, So‐Yeon; Yoon, Myeong‐Ho; Hwang, Gyo‐Seung; Tahk, Seung‐Jea; Shin, Joon‐Han

doi:10.3109/10641963.2015.1047943

Cited by 15 publications

(11 citation statements)

References 24 publications

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“…In agreement with prior studies 5 , 20 , 21 , we observed substantial hypertrophy in patients with ESRD, yet only a moderate correlation was observed between simultaneous measurements of LVMI and divergence. Similarly, reduced global longitudinal strain in patients with ESRD has been demonstrated using both CMR 22 and echocardiography 23 – 25 . While we also observed reduced mean GLS in patients with ESRD compared to healthy controls, most values remained well within the normal variation of healthy cohorts 11 , 26 .…”

Section: Discussionmentioning

confidence: 87%

Quantitative Gadolinium-Free Cardiac Fibrosis Imaging in End Stage Renal Disease Patients Reveals A Longitudinal Correlation with Structural and Functional Decline

Stromp

Spear

Holtkamp

et al. 2018

Sci Rep

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Patients with end stage renal disease (ESRD) suffer high mortality from arrhythmias linked to fibrosis, but are contraindicated to late gadolinium enhancement magnetic resonance imaging (MRI). We present a quantitative method for gadolinium-free cardiac fibrosis imaging using magnetization transfer (MT) weighted MRI, and probe correlations with widely used surrogate markers including cardiac structure and contractile function in patients with ESRD. In a sub-group of patients who returned for follow-up imaging after one year, we examine the correlation between changes in fibrosis and ventricular structure/function. Quantification of changes in MT revealed significantly greater fibrotic burden in patients with ESRD compared to a healthy age matched control cohort. Ventricular mechanics, including circumferential strain and diastolic strain rate were unchanged in patients with ESRD. No correlation was observed between fibrotic burden and concomitant measures of either circumferential or longitudinal strains or strain rates. However, among patients who returned for follow up examination a strong correlation existed between initial fibrotic burden and subsequent loss of contractile function. Gadolinium-free myocardial fibrosis imaging in patients with ESRD revealed a complex and longitudinal, not contemporary, association between fibrosis and ventricular contractile function.

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Section: Discussionmentioning

confidence: 87%

Quantitative Gadolinium-Free Cardiac Fibrosis Imaging in End Stage Renal Disease Patients Reveals A Longitudinal Correlation with Structural and Functional Decline

Stromp

Spear

Holtkamp

et al. 2018

Sci Rep

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“…The most widely investigated functional LV characteristic to predict patient outcome after STEMI is LV ejection fraction (LVEF) [ 3 ]. Several structural LV characteristics have also shown to be important predictors of cardiovascular adverse events and death, including LV end diastolic volume (LVEDV), end systolic volume (LVESV) and mass (LVM) [ 4 – 8 ]. Cardiovascular magnetic resonance (CMR) imaging is the current reference standard for assessing ventricular volumes and mass [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Predictors of left ventricular remodeling after ST-elevation myocardial infarction

Hendriks

Hartman

Vlaar

et al. 2017

Int J Cardiovasc Imaging

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Adverse left ventricular (LV) remodeling after acute ST-elevation myocardial infarction (STEMI) is associated with morbidity and mortality. We studied clinical, biochemical and angiographic determinants of LV end diastolic volume index (LVEDVi), end systolic volume index (LVESVi) and mass index (LVMi) as global LV remodeling parameters 4 months after STEMI, as well as end diastolic wall thickness (EDWT) and end systolic wall thickness (ESWT) of the non-infarcted myocardium, as compensatory remote LV remodeling parameters. Data was collected in 271 patients participating in the GIPS-III trial, presenting with a first STEMI. Laboratory measures were collected at baseline, 2 weeks, and 6–8 weeks. Cardiovascular magnetic resonance imaging (CMR) was performed 4 months after STEMI. Linear regression analyses were performed to determine predictors. At baseline, patients were 21% female, median age was 58 years. At 4 months, mean LV ejection fraction (LVEF) was 54 ± 9%, mean infarct size was 9.0 ± 7.9% of LVM. Strongest univariate predictors (all p < 0.001) were peak Troponin T for LVEDVi (R2 = 0.26), peak CK-MB for LVESVi (R2 = 0.41), NT-proBNP at 2 weeks for LVMi (R2 = 0.24), body surface area for EDWT (R2 = 0.32), and weight for ESWT (R2 = 0.29). After multivariable analysis, cardiac biomarkers remained the strongest predictors of LVMi, LVEDVi and LVESVi. NT-proBNP but none of the acute cardiac injury biomarkers were associated with remote LV wall thickness. Our analyses illustrate the value of cardiac specific biochemical biomarkers in predicting global LV remodeling after STEMI. We found no evidence for a hypertrophic response of the non-infarcted myocardium.

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“…Myocardial structural and functional alterations beyond EF representing LV systolic function might affect adverse clinical outcomes in patients with early remodeling. [ 4 ] Late remodeling, including LVH and alterations in ventricular architecture, is an adaptive response that can offset chronically increased hemodynamic load, attenuate progressive dilatation, and stabilize contractile function. [ 9 ] The progression of LVMI was related to increased risk for recurrent MI in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 – 3 ] We have previously reported that LVH is associated with increased rate of adverse clinical outcomes in 30-day survivors after ST-elevation myocardial infarction (STEMI) with successful percutaneous coronary intervention (PCI). [ 4 ] In the previous study, we examined the prognostic significance of LVH only at baseline without evaluating the impact of their serial changes. The progression or regression of LVH might affect the clinical outcomes.…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of left ventricular mass change in patients with ST-elevation myocardial infarction

et al. 2018

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Prognostic significance between progression of left ventricular hypertrophy (LVH) and clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) is uncertain. The objective of this study was to investigate prognostic impact of progression of LV mass index (LVMI) in patients with STEMI.We analyzed the data and clinical outcomes of patients with STEMI who received successful coronary intervention. A total of 200 patients who had echocardiographic follow-up between 12 and 36 months were finally enrolled. According to change in LVMI compared to baseline LVMI, patients were classified into progression group and nonprogression group. Progression of LVMI was defined when increment of LMVI was greater than 10% compared to baseline LVMI. End points were major adverse cardiac events within 5 years, including death, recurrent MI, target vessel revascularization, and hospitalization due to heart failure.Progression of LVMI occurred in 55 patients. In the progression group, rate of recurrent MI was higher (13 vs 2%, P = .026) and the event-free survival of recurrent MI was significantly worse (log-rank P < .001) than that in the nonprogression group. Adjusted hazard ratio of progression of LVMI for recurrent MI was 10.253 (95% confidence intervals 2.019–52.061, P = .005).Increased LVMI was an independent predictor for adverse events, especially for recurrent MI, in patients with STEMI.

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Left ventricular hypertrophy on long-term cardiovascular outcomes in patients with ST-elevation myocardial infarction

Abstract: LVH was associated with increased rate of adverse clinical outcomes in 30-day survivors after STEMI, who underwent successful coronary intervention.

Cited by 15 publications

References 24 publications

Quantitative Gadolinium-Free Cardiac Fibrosis Imaging in End Stage Renal Disease Patients Reveals A Longitudinal Correlation with Structural and Functional Decline

Quantitative Gadolinium-Free Cardiac Fibrosis Imaging in End Stage Renal Disease Patients Reveals A Longitudinal Correlation with Structural and Functional Decline

Predictors of left ventricular remodeling after ST-elevation myocardial infarction

Prognostic impact of left ventricular mass change in patients with ST-elevation myocardial infarction

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