Left ventricular hypertrophy reclassification and death: application of the Recommendation of the American Society of Echocardiography/European Association of Echocardiography

Barbieri, Andréa; Bursi, Francesca; Mantovani, Francesca; Valenti, Chiara; Quaglia, Michele; Berti, Elena; Marino, Massimiliano; Modena, Maria Grazia

doi:10.1093/ejechocard/jer176

Cited by 64 publications

(49 citation statements)

References 28 publications

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“…In keeping with the results by Barbieri et al, 28 our study extends to a general population the notion that LVH as defined by linear dimensions of LV wall thickness has no independent value in predicting cardiovascular outcomes. At variance from the above-mentioned study investigating the predictive value of single linear LV parameter (IVS), 28 our analysis included also PW thickness, the sum of IVS plus PW thickness, and RWT. The lack of a significant relationship between these linear LV measurements and cardiovascular prognosis in our study may have multiple explanations.…”

Section: Discussionsupporting

confidence: 89%

“…More recently, an observational study by Barbieri et al that included 2,445 adults referred to a single-center echocardiographic laboratory for unselected indications showed that LVH, as defined by sex-specific cutoffs of IVS thickness recommended by the ASE/EAE guidelines, was unrelated to allcause death during a mean follow-up period of 2.5 years. 28 In contrast, LV mass/BSA values retained a significant, graded association with total mortality after adjustment for age, sex, LV ejection fraction, presence of moderate valve disease, and atrial fibrillation. In keeping with the results by Barbieri et al, 28 our study extends to a general population the notion that LVH as defined by linear dimensions of LV wall thickness has no independent value in predicting cardiovascular outcomes.…”

Section: Discussionmentioning

confidence: 90%

“…28 In contrast, LV mass/BSA values retained a significant, graded association with total mortality after adjustment for age, sex, LV ejection fraction, presence of moderate valve disease, and atrial fibrillation. In keeping with the results by Barbieri et al, 28 our study extends to a general population the notion that LVH as defined by linear dimensions of LV wall thickness has no independent value in predicting cardiovascular outcomes. At variance from the above-mentioned study investigating the predictive value of single linear LV parameter (IVS), 28 our analysis included also PW thickness, the sum of IVS plus PW thickness, and RWT.…”

Section: Discussionmentioning

confidence: 90%

See 2 more Smart Citations

Differential Value of Left Ventricular Mass Index and Wall Thickness in Predicting Cardiovascular Prognosis: Data From the PAMELA Population

Cuspidi

Facchetti

Bombelli

et al. 2014

American Journal of Hypertension

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In the last 5 decades, several studies have demonstrated that left ventricular (LV) hypertrophy (LVH), either determined by standard 12-lead electrocardiography or by echocardiography, is a powerful, independent predictor of nonfatal and fatal cardiovascular events or all-cause mortality in the general population 1-3 as well as in specific clinical settings, such as patients with systemic hypertension, 4-7 myocardial infarction, 8 angina pectoris, 9 congestive heart failure, 10 or chronic renal failure, 11 and elderly individuals. 12 Furthermore, regression or reduction of electrocardiographic and echocardiographic indexes of LVH has been repeatedly shown to predict a lower risk for subsequent cardiovascular disease and death. [13][14][15] Echocardiography is recognized to be more sensitive than electrocardiography in detecting LVH, and its value as a predictor of LVH-related cardiovascular outcomes has been extensively investigated. 16 In the majority of reports, LVH was diagnosed by calculating LV mass; this parameter has a greater agreement with necropsy-determined LV mass compared with echographic LV wall thickness (83.0% vs. 39.5%). 17 Yet, as recently documented by 2 multicentered, observational studies, a large fraction of echocardiographically based reports do not provide quantitative data on LV mass and LV geometry, this being the case also in hypertensive patients. Moreover, in several laboratories, LVH is only defined by linear measurements of LV wall thickness rather than by the more complex and time-consuming determination of LV mass. 18,19 To the best of our knowledge, no population-based studies have compared the value of LV wall thickness and LV mass in predicting cardiovascular prognosis. This study was undertaken to address this issue by analyzing the data obtained in the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study, a population-based, prospective, observational study performed in Italy. background Data on the prognostic value of echocardiographic left ventricular (LV) hypertrophy (LVH) as defined by LV wall thickness rather than LV mass estimate are scarce and not univocal. Thus, we investigated the value of LV mass index, wall thickness, and relative wall thickness (RWT) in predicting cardiovascular events in the PAMELA population.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Differential Value of Left Ventricular Mass Index and Wall Thickness in Predicting Cardiovascular Prognosis: Data From the PAMELA Population

Cuspidi

Facchetti

Bombelli

et al. 2014

American Journal of Hypertension

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“…LV mass index might have been a better tool to exclude LV hypertrophy than the determination of septal wall thickness. However, it seems that the inferiority of septal wall thickness versus LV mass index is less when only excluding rather than grading LV hypertrophy severity (31).…”

Section: Study Limitationsmentioning

confidence: 99%

Longitudinal Development of Left Ventricular Diastolic Function in Patients With Type 2 Diabetes

et al. 2014

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OBJECTIVELeft ventricular diastolic dysfunction (LVDD) is considered to be common in patients with type 2 diabetes mellitus (T2DM), but information on its progression over time is lacking. We studied the longitudinal development of left ventricular diastolic function (LVDF) and myocardial blood flow reserve in patients with T2DM who were free from clinically detectable cardiovascular disease. RESEARCH DESIGN AND METHODSThe LVDF was assessed in 73 patients with T2DM (mean age 67 6 7 years; males 51%) on two occasions separated by 6.4 6 0.8 years. RESULTSAt baseline, LVDD was observed in 23 of the patients (32%). During follow-up, the LVDF normalized in 10 of these patients (43%) and remained unchanged in 13 of them (57%). Of the 50 patients (68%) with normal LVDF at baseline, LVDD developed in 9 (18%). Paired evaluation of myocardial blood volume index was available from 22 patients with LVDD and remained unchanged over time. CONCLUSIONSThe condition of the majority of the investigated patients with LVDD improved or remained stable over a period of 6 years.Myocardial dysfunction, in particular relaxation disturbances, occurs in patients with type 2 diabetes even in the absence of such conditions as hypertension and coronary artery disease (1). The background structural and functional changes relate to glucometabolic perturbations (2,3), but factors such as increasing age, obesity, hypertension, and coronary artery disease may also contribute to myocardial stiffness (4), and often coexist in patients with diabetes.Left ventricular diastolic dysfunction (LVDD) is characterized by echocardiographic indices of impaired early diastolic filling, prolonged isovolumetric relaxation (5), and also, in more advanced stages, increased atrial volume (6). It has been referred to as a progressive condition increasing the risk for subsequent overt heart failure and compromised survival (7,8). The prevalence of LVDD in patients with type 2 diabetes has been estimated to be between 35% and 60% (9-11). The wide range is mainly explained by varying definitions of LVDD, applied echocardiographic techniques, and population characteristics. Considering the rather high prevalence of LVDD, a better understanding of its time-dependent development may identify high-risk populations as well as create opportunities to prevent or at least delay its progression. However, longitudinal studies of the natural course of left ventricular diastolic function (LVDF) in patients with type 2 diabetes who were free

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“…It is also well recognised that infants born to diabetic mothers have cardiomegaly, even after controlling for birth weight (7,8). The presence of left ventricular hypertrophy (LVH) can be potentially life threatening and has been associated with the risk of sudden death, often due to arrhythmias (9,10). Therefore, patients with CHI may be at risk of significant cardiac morbidity, particularly in longterm follow-up.…”

Section: Introductionmentioning

confidence: 99%

The association of cardiac ventricular hypertrophy with congenital hyperinsulinism

Banerjee

Avatapalle

Petkar

et al. 2012

European Journal of Endocrinology

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Objective: Ventricular hypertrophy (VH) has been observed in children with congenital hyperinsulinism (CHI), a condition of hypoglycaemia characterised by dysregulated insulin secretion, but the prevalence is not known. Patients and methods: Cardiac assessment was performed in children (nZ49) with CHI at diagnosis and follow-up. Two dimensional and Doppler echocardiography studies were used to assess cardiac structures, while M-mode study was used to measure left ventricular (LV) dimensions, subsequently converted to Z scores. Where possible, LV hypertrophy was confirmed by LV mass index (g/m 2.7 ) O95th centile. Results: Cardiac structural lesions were found in 14 (28%) children. At initial echocardiography, VH was present in 31 (65%) children with median (range) LV posterior wall dimension in diastole Z scores of C1.6 (K2.4 to C5.8) and interventricular septal wall dimension in end diastole Z scores of C1.9 (K1.7 to C17.2). At follow-up echocardiography, performed after an interval of 178 (45-390) days, VH persisted in 16 (33%) children. In regression analysis, the presence of VH (odds ratio (95% confidence intervals) 1.1 (1.0-1.2), PZ0.04) at initial echocardiography was correlated with maximum glucose requirement at diagnosis, indicating that severity of CHI at presentation may play a role in the pathogenesis of VH. Conclusions: A significant proportion of children with CHI have cardiac structural lesions. A majority also have VH, which may be associated with the severity of CHI at diagnosis. VH may persist in some children, which requires careful long-term cardiac review.

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Left ventricular hypertrophy reclassification and death: application of the Recommendation of the American Society of Echocardiography/European Association of Echocardiography

Cited by 64 publications

References 28 publications

Differential Value of Left Ventricular Mass Index and Wall Thickness in Predicting Cardiovascular Prognosis: Data From the PAMELA Population

Differential Value of Left Ventricular Mass Index and Wall Thickness in Predicting Cardiovascular Prognosis: Data From the PAMELA Population

Longitudinal Development of Left Ventricular Diastolic Function in Patients With Type 2 Diabetes

The association of cardiac ventricular hypertrophy with congenital hyperinsulinism

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