“…The contribution of intrauterine diabetes exposure to LV diastolic filling dynamics (E/A) was explored in linear regression to adjust for known determinants of E/A (LVID, diastolic blood pressure) and potential confounders (HbA1c, fasting glucose, weight, height) that were different between our exposure groups or had previously been identified as determinants of E/A. 148,162,165 However, in our study, the only determinant that was significant in fully adjusted models was LVID. This could be explained by the small difference of LV diastolic function markers between groups or the possibility that intrauterine diabetes exposure might not contribute meaningfully to impairments in LV morphology and function in adolescents.…”