The effects of dopamine on the left ventricular regional wall motion were studied in 11 patients with dilated cardiomyopathy by use of two-dimentional echocardiography and compared with the findings on the uptake of thallium-201. There were no significant changes in heart rate after dopamine infusion (6pg/kg/min).However, the administration of dopamine significantly reduced PEP/ET and increased the systolic blood pressure, fractional shortening, ejection fraction and mvcf. The percentage of segments with reduced thallium-uptake area was significantly higher in abnormal wall motion segments than in normal wall segments both before and after dopamine administration. The percentage of segments with reduced thallium-uptake area was significantly higher in abnormal wall motion segments after loading than in normal wall segments before loading or in dopamine responding segments. However, in reduced uptake area, the asynergy of the left ventricle was improved significantly after dopamine administration. These results demonstrated that the abnormality of Tl-uptake was correlated roughly to the asynergy of the left ventricle, but that the state of remaining myocardium was not necessarily evaluated correctly by Ti-uptake. Dopamine loading seemed to be useful for more accurate evaluation of myocardial residual function. dilated cardiomyopathy ; regional wall motion ; responses to dopamine ; thallium-201 scintigraphy Dilated cardiomyopathy (DCM) is known as a myocardial disease of unknown etiology, clinically demonstrating the left ventricular dilatation and broad hypokinetic wall motion (Goodwin and Oakley 1972; WHO/ISFC 1980). However, recent studies of this disease using thallium T1-201 myocardial scintigraphy have revealed not only instances of a homogeneous reduced T1-201 uptake but also those of a localized defect of T1-201 uptake (Bulkley et al. 1977;Saltissi et al.