Left ventricular structure and diastolic function with human ageing Relation to habitual exercise and arterial stiffness

Gates, Phillip E.; Tanaka, Hirofumi; Graves, Jayne; Seals, Douglas R.

doi:10.1016/j.ehj.2003.09.026

Cited by 123 publications

(114 citation statements)

References 42 publications

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“…29 Given this, it is reasonable to hypothesize that both age and cardiorespiratory fitness are associated with increased LV wall thickness and mass. Gates et al 30 reported that the highest mean values for these LV characteristics were observed in older endurance-trained men, suggesting an additive effect of ageing and exercise behaviour. In contrast to the previous findings, our results indicated that RWT in old, less fit women was significantly thicker than in fit peers.…”

Section: Arterial Stiffnessmentioning

confidence: 97%

Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling

et al. 2009

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Arterial stiffening, hypertension and left ventricular (LV) remodelling are associated with increased risk of cardiovascular disease. Cardiorespiratory fitness is associated with cardiovascular function and reduced risk of cardiovascular disease. This cross-sectional study was carried out to determine the relationships between cardiorespiratory fitness, arterial stiffness, blood pressure (BP) and LV remodelling in women. On the basis of peak oxygen uptake, a total of 159 premenopausal (young) and postmenopausal (older) women were categorized into either low (unfit) or high (fit) cardiorespiratory fitness groups. The arterial stiffness and LV remodelling were measured by brachialankle pulse wave velocity (baPWV) and carotid augmentation index (AI) and LV relative wall thickness (RWT). Two-way analysis of variance indicated a significant interaction between age and cardiorespiratory fitness in baPWV, carotid AI, BP and RWT. In the older group, arterial stiffness (baPWV; 1401 ± 231 vs 1250 ± 125 cm s -1 , Po0.01, AI; 32.9±9.9 vs 24.8±10.1%, Po0.01), systolic blood pressure (SBP) (130 ± 22 vs 117 ± 15 mm Hg, Po0.01) and RWT (0.47 ± 0.08 vs 0.42±0.04, Po0.05) in fit women were lower than in unfit women. In older women, RWT was significantly related to baPWV (r ¼ 0.46, Po0.01), carotid AI (r ¼ 0.29, Po0.05), SBP (r ¼ 0.57, Po0.01) .V 2peak (r ¼ À0.32, Po0.05). In young women, they were not significant correlations, except for a weak correlation between RWT and SBP (r ¼ 0.21, Po0.05). These results suggest that higher cardiorespiratory fitness is associated with lower arterial stiffness, BP and RWT in older women.

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Section: Arterial Stiffnessmentioning

confidence: 97%

Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling

et al. 2009

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“…Aortic PWV increases with age, but the difference in aortic PWV between younger and older adults has been shown to be smaller in endurance-trained men, compared with recreationally inactive and sedentary men. 15) One study showed no age-related increase in aortic stiffness in physically active women. 14) Endurance-trained athletes also had greater arterial compliance compared with age-matched sedentary control subjects.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16] Habitual aerobic-endurance exercise attenuates age-associated increases in arterial stiffness in healthy subjects. Aortic PWV increases with age, but the difference in aortic PWV between younger and older adults has been shown to be smaller in endurance-trained men, compared with recreationally inactive and sedentary men.…”

Section: Discussionmentioning

confidence: 99%

Effects of Physical Activity and Aerobic Exercise Capacity on Aortic Stiffness in Patients With Untreated Hypertension

Kim

Bae

et al. 2009

Korean Circ J

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Background and Objectives: High aerobic exercise capacity and sport-related physical activity are reported to be inversely associated with arterial stiffness in healthy young adults. However, it is unknown whether increased physical activity and/or high aerobic exercise capacity attenuate arterial stiffness in patients with untreated hypertension. Subjects and Methods: We studied subjects with never-treated hypertension {n=84 (55 males); mean age±SD, 49±7 years; age range, 36-65 years}. We excluded subjects with a history of diabetes, angina, myocardial infarction, major arrhythmia, or cerebrovascular diseases and those who were taking any cardiovascular medications, including lipid-lowering agents. Carotid intima-media thickness (IMT) and heart-femoral pulse wave velocity (hfPWV) were measured before exercise testing was performed. Physical activity was estimated using a modified Baecke questionnaire. Aerobic exercise capacity was measured with maximal cardiopulmonary exercise testing (maximum oxygen uptake, Vo 2 max). Results: Linear regression analysis showed a significant inverse correlation between sport-index and hfPWV (r=-0.404 ; p<0.001), which multiple linear regression analysis showed to be independent of the individual variables of age, gender, body mass index, mean arterial pressure, total cholesterol, fasting blood glucose, and heart rate (beta=-0.277 ; p=0.004). However, the work-and leisure-indices and Vo 2 max were not associated with hfPWV (p>0.05). Carotid IMT was not associated with physical activity indices or Vo 2 max. Conclusion: In patients with untreated hypertension, increased sport activity was associated with lower aortic stiffness, but high aerobic exercise capacity was not. These results suggest that regular daily exercise, but not exercise capacity, is an important determinant of aortic stiffness in patients with untreated hypertension. (Korean Circ J

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“…Gates et al (2003) noted that regular physical activity does not stimulate changes in diastolic function of the left ventricle in healthy aging men. Observation of Gates et al coincident with the result obtained in our control group, in which after the observation period was a significant reduction in boththe LVEDD and the LVEDV (p<0,001) [19]. Belardinelli et al (2001) did not notice significant changes in the left ventricle diastolic function in physically active patients compared with inactive, in the course of the 6-month follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…It is not resolved whether exercise training used in cardiac rehabilitation can improve diastolic function of the left ventricle [18]. Gates et al (2003) noted that regular physical activity does not stimulate changes in diastolic function of the left ventricle in healthy aging men. Observation of Gates et al coincident with the result obtained in our control group, in which after the observation period was a significant reduction in boththe LVEDD and the LVEDV (p<0,001) [19].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Indoor Cycling Training on Hemodynamic Parameters of the Left Ventricle of Men With Ischaemic Heart Disease or After Myocardial Infarction

Глоц¹,

Novak²

2017

Russ J Cardiol

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Aim. Younger age of the cardiac patients somehow necessitates the use of modern forms of physical training, which become alternative and interesting means to provide effective rehabilitation. One such form is endurance Indoor Cycling training. In the present study attempts to determine the impact of 1-month Indoor Cycling training on hemodynamic left ventricle parameters of men with ischemic heart disease or after myocardial infarction were made. material and methods. The study group consisted of 50 men under the model A of the 2 nd phase of cardiac rehabilitation (20 men of the Indoor Cycling group, IC, 20 men rehabilitated accordingly to the recommendations of the Polish Cardiac Society -a standard group, ST and 10 people who did not participate in any cardiac rehabilitation program -a control group, C). The average age of all patients was 56,60±8,25 years, the average left ventricular ejection fraction was 56%±4,00. Results. Echocardiogram did not show significant changes after 1-month of training in both groups undergoing comprehensive cardiac rehabilitation. Paralleled to the preliminary study in the group of patients who refused to participate in the cardiac rehabilitation, results showed a reduction in all echocardiographic parameters, including a significant decrease in the left ventricular end diastolic diameter (52,80 vs 50,50 mm) and volume (134,85 vs 121,88 ml; both variables at p<0,001), as well as in the left ventricular mass (239,46 vs 208,61 g; p=0,002) Цель. Молодой возраст кардиологических пациентов делает необходимым использование современных форм физической тренировки, становящихся альтернативными и более востребованными путями эффективной реабилита-ции. Одна из таких форм -тренировка выносливости на велотренажёре в помещении. Текущее исследование предполагает изучить влияние одноме-сячных велотренировок на гемодинамические параметры левого желудочка мужчин с ишемической болезнью сердца и после инфаркта миокарда. Материал и методы. Группа исследования включала 50 мужчин в модель А второй фазы сердечно-сосудистой реабилитации (20 мужчин группы вело-тренажёра (ВТ), 20 реабилитируемых в соответствии с рекомендациями Поль-ского кардиологического общества -стандартная группа (СТ), и 10 человек в группе контроля не участвовали в какой-либо реабилитации). Средний воз-раст всех пациентов был 56,60±8,25 лет, средняя фракция выброса левого желудочка -56%±4,00. Результаты. Эхокардиография не показала значимых различий после 1 месяца тренировок в обеих группах кардиореабилитации. В группе отказав-шихся от какой-либо реабилитации было показано снижение всех эхокардио-графических показателей, включая значимое снижение конечно-диастоличе-ского диаметра левого желудочка (52,80 vs 50,50 мм) и объёма (134,85 vs 121,88 мл; обе переменные с p<0,001), как и массы левого желудочка (239,46 vs 208,61 г; p=0,002) и индекса массы левого желудочка (123,52 vs 107,61 г/м 2 ; p=0,001). Заключение. Не было показано негативного влияния велотренировок на мор-фологические параметры левого желудочка. Велотренировки во вто...

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Left ventricular structure and diastolic function with human ageing Relation to habitual exercise and arterial stiffness

Abstract: We conclude that in contrast to its ability to favourably modulate the stiffness of large elastic arteries, regular aerobic-endurance exercise does not consistently modulate the changes in LV structure and diastolic function that occur with physiological ageing in men.

Cited by 123 publications

References 42 publications

Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling

Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling

Effects of Physical Activity and Aerobic Exercise Capacity on Aortic Stiffness in Patients With Untreated Hypertension

The Impact of Indoor Cycling Training on Hemodynamic Parameters of the Left Ventricle of Men With Ischaemic Heart Disease or After Myocardial Infarction

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