2009
DOI: 10.1038/hr.2008.30
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Left ventricular structure in relation to the human SAH gene in the European Project on Genes in Hypertension

Abstract: Earlier studies showed association of the human SAH (Spontaneously hypertensive rat-clone A-Hypertension associated) gene with hypertension and obesity. Left ventricular mass index (LVMI) increases with blood pressure and body mass index. In a family-based population study (54.5% women; mean age, 43.1 years), we measured LVMI, mean wall thickness (MWT) and the left ventricular internal diameter (LVID) at end-diastole in 699 non-Slavic and 493 Slavic participants. In multivariable-adjusted analyses, we investig… Show more

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Cited by 5 publications
(3 citation statements)
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“…This gene was previously reported to associate with hypertension in rats [43] and in humans [44] and also with obesity hypertension in humans [45] , but there is some controversy [46] . Other studies relate it with ventricular deformations such as left ventricular mass index and mean wall thickness [47] . The ERI2 gene was also associated with Cornell product (p = 7.87×10 −9 ).…”
Section: Resultsmentioning
confidence: 99%
“…This gene was previously reported to associate with hypertension in rats [43] and in humans [44] and also with obesity hypertension in humans [45] , but there is some controversy [46] . Other studies relate it with ventricular deformations such as left ventricular mass index and mean wall thickness [47] . The ERI2 gene was also associated with Cornell product (p = 7.87×10 −9 ).…”
Section: Resultsmentioning
confidence: 99%
“…Those genes are the following: 1) Neurotrophic tyrosine kinase, receptor, type 3 (Ntrk3), a gene studied in the Japanese population [20]; 2) Prolylcarboxypeptidase (Prcp) D allele, which is coupled to chronic hypertension and associated with a significant increased risk of preeclampsia in both African-American and non-African-American women [24]; 3) Sodium channel gamma subunit gene (SCNN1G), multiple polymorphisms in human epithelial SCNN1G are associated with essential hypertension in several populations [25-27]; 4) Calpain-5 (Capn5), Capn5 variants are associated with diastolic blood pressure and cholesterol levels in the Spanish population [28]; 5) Solute Carrier family 9 member 2 (SLC9A2), Uromodulin (UMOD), and Elastin (ELN), five polymorphisms in these 3 genes were associated with hypertension status [29]; 6) Uncoupling protein 2 (Ucp2), a common polymorphism of this gene is associated with hypertension in the Japanese population [30,31]; 7) Inositol polyphosphate phosphatase-like 1 (INPPL1 and SHIP2), variants of these genes affect essential hypertension [32]; 8) Purinergic receptor p2y, g protein-coupled, 2 (P2ry2), P2ry2 is among 61 non-synonymous polymorphisms of 41 hypertension candidate genes with blood pressure variation in the Japanese population [19]; 9) SCNN1B, this gene has shown a modest-sized but highly significant effect on common genetic variation in SCNN1B on plasma potassium [33]. Interactions between the rs889299 SNP and functional SNPs in other genes influencing aldosterone-responsive distal tubular electrolyte transport may be important in the etiology of essential hypertension; 10) Spontaneously hypertensive rat-clone A-hypertension-associated gene (SAH), SAH has been extensively investigated and its gene variants are associated with obesity-related hypertension in Caucasians [34,35].…”
Section: Candidate Genes For the Qtl On Gene-rich And/or Gene-poor Chmentioning
confidence: 99%
“…As funções dos produtos do gene SAH ainda não foram totalmente descobertas (Iwai e Inagami, 1991;Iwai, Inagami et al, 1994). Porém, algumas suposições têm sido feitas, sobre o gene e suas relações com a hipertensão ligada à obesidade (Telgmann, Brand et al, 2007;Jin, Kuznetsova et al, 2009), altos níveis plasmáticos de colesterol (Haketa, Soma et al, 2004) e neuropatias (Narita, Saito et al, 2002). Sabe-se também que ele se localiza no cromossomo 1 do genoma dos ratos (Lindpaintner, Hilbert et al, 1993).…”
Section: 4-o Gene Codificador Da Proteína Atrapunclassified