Left ventricular systolic and diastolic function assessed with two-dimensional and Doppler echocardiography in “white coat” hypertension

Soma, Johannes; Widerøe, Tor Erik; Dahl, Ketil; Rossvoll, Ole; Skjærpe, Terje

doi:10.1016/0735-1097(96)00129-5

Cited by 27 publications

(16 citation statements)

References 40 publications

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“…It should not, however, be assumed that white coat hypertension is similar to normotension and therefore harmless to the heart 6. In fact more recent studies including larger numbers of normotensive individuals have raised doubts about white coat hypertension as a benign condition 7 – 10. This is supported by an epidemiological study that showed an unfavourable risk profile in young adults with white coat hypertension including a high prevalence of familial, haemodynamic, and metabolic risk factors 11…”

Section: Introductionmentioning

confidence: 99%

Changes in left ventricular structure and function in patients with white coat hypertension: cross sectional survey

Muscholl

Bröckel

et al. 1998

BMJ

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Results: White coat hypertension was more common in men than women (10.9% versus 8.2% respectively) and positively related to age and body mass index.After adjustment for these variables, white coat hypertension was associated with an increase in left ventricular mass and an increased prevalence of left ventricular hypertrophy (odds ratio 1.9, 95% confidence interval 1.2 to 3.2; P = 0.009) compared with normotensive patients. The increase in left ventricular mass was secondary to significantly increased septal and posterior wall thicknesses whereas end diastolic diameters were similar in both groups with white coat hypertension or normotension. Additionally, the systolic white coat effect (difference between blood pressures recorded by a technician and physician) was associated with increased left ventricular mass and increased prevalence of left ventricular hypertrophy (P < 0.05 each). Values for systolic left ventricular function (M mode fractional shortening) were above normal in subjects with white coat hypertension whereas diastolic filling and left atrial size were similar to those in normotension. Conclusion: About 10% of the general population show exaggerated inotropic and blood pressure responses when mildly stressed. This is associated with an increased risk of left ventricular hypertrophy.

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Section: Introductionmentioning

confidence: 99%

Changes in left ventricular structure and function in patients with white coat hypertension: cross sectional survey

Muscholl

Bröckel

et al. 1998

BMJ

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show abstract

“…[15][16][17] On the other hand, different results have been obtained in other reports. [18][19][20][21][22][23][24][25][26] Various studies have suggested that only about one-half to two-thirds of the variation in the anatomic extent of atherosclerosis and risk for atherosclerotic vascular disease can be explained by classic risk factors. 27,28 Therefore, new risk factors have been investigated.…”

Section: Introductionmentioning

confidence: 99%

Circulating homocysteine levels in sustained and white coat hypertension

et al. 2003

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Although white coat hypertension has been widely studied in the last years, its risk profile is not yet completely clear. The aim of this study was to evaluate circulating homocysteine levels, an emerging cardiovascular risk factor, in subjects with white coat and sustained hypertension. We selected 31 sustained hypertensive subjects, 31 white coat hypertensive subjects and 31 normotensive subjects matched for age, gender, body mass index and occupation. Women were also matched for menopausal status. Subjects with smoking habit, dyslipidaemia and diabetes mellitus were excluded from the study. White coat hypertension was defined as clinical hypertension and daytime ambulatory blood pressure o135/85 mmHg. Blood samples were drawn after a fasting period of 12 h for routine laboratory tests and homocysteine determination. Homocysteine levels were evaluated by fluorescence polarization immunoassay. Creatinine, glucose, cholesterol and triglycerides were not different among the groups. White coat hypertensive subjects had significantly lower homocysteine levels than sustained hypertensive patients (8.2 7 2.0 vs 12.6 7 3.9 lmol/l, P ¼ 0.0003). No significant difference was observed between white coat hypertensive and normotensive subjects regarding this parameter (8.2 7 2.0 vs 7.6 7 1.9 lmol/l, P ¼ 0.9). In conclusion, our data show that middle-aged white coat hypertensive subjects without other cardiovascular risk factors have lower circulating homocysteine levels than sustained hypertensive patients suggesting that they are at lower cardiovascular risk.

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“…Most data indicate that this condition (which occurs in about 10% of the population [18]) represents a lesser cardiovascular risk than the condition characterized by both an office and an ambulatory BP elevation. Conflicting data about prevalence of organ damage, cardiovascular risk and proneness to future hypertension make it uncertain whether or not this represents a truly innocent phenomenon [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. This suggests that caution should be used when deciding whether or not such patients should be treated.…”

Section: Isolated Office (White-coat) Hypertensionmentioning

confidence: 98%

European Society of Hypertension Scientific Newsletter: clinical value of ambulatory blood pressure monitoring

Mallion¹,

Baguet²,

Mancia

2006

Journal of Hypertension

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Left ventricular systolic and diastolic function assessed with two-dimensional and Doppler echocardiography in “white coat” hypertension

Abstract: The arterial pressure response in subjects with white coat hypertension is associated with increased left ventricular external work, increased end-systolic wall stress and alterations of left ventricular filling but normal ejection fraction and velocity of circumferential fiber shortening.

Cited by 27 publications

References 40 publications

Changes in left ventricular structure and function in patients with white coat hypertension: cross sectional survey

Changes in left ventricular structure and function in patients with white coat hypertension: cross sectional survey

Circulating homocysteine levels in sustained and white coat hypertension

European Society of Hypertension Scientific Newsletter: clinical value of ambulatory blood pressure monitoring

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