Left Ventricular Systolic Dysfunction in Patients with Obstructive Sleep Apnea Syndrome

Laaban, J. P.; Pascal-Sébaoun, S; Bloch, Evelyne; Orvoen-Frija, E; Oppert, Jean‐Michel; Huchon, G

doi:10.1378/chest.122.4.1133

Cited by 155 publications

(92 citation statements)

References 26 publications

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“…Patients were divided into five groups according to their LVEF levels: patients with LVEF Ն0.6, 0.5 to 0.6, 0.4 to 0.5, 0.3 to 0.4, and Ͻ0.3, respectively. LVEF Ͻ0.5 was considered as LV systolic dysfunction (14,15).…”

Section: Echocardiographymentioning

confidence: 99%

Prognostic Value of Reduced Left Ventricular Ejection Fraction at Start of Hemodialysis Therapy on Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients

Yamada

Ishii²,

Takahashi

et al. 2010

Clinical Journal of the American Society of Nephrology

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Background and objectives: Cardiac failure is directly affected by left ventricular (LV) dysfunction, and particularly LV systolic dysfunction is strongly associated with survival in ESRD patients. The aim of this study was to determine the prognostic value of reduced LV ejection fraction (LVEF) measured at the time of initiation of hemodialysis (HD) in incident HD patients.Design, setting, participants, & measurements: 1254 consecutive ESRD patients who electively started HD therapy were screened by echocardiography within 1 month after its inception. They were divided into five groups according to LVEF levels with a decrease of 0.1 each and were followed up for up to 7 years. Survival was examined with the Kaplan-Meier method and compared using the log-rank test.Results: Among the 1254 patients, LVEF levels >0. Conclusions: Reduced LVEF on starting HD therapy could stratify risk of cardiovascular and all-cause mortality in ESRD patients. Screening by echocardiography at start of HD therapy might be recommended to predict prognosis in patients with ESRD.

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Section: Echocardiographymentioning

confidence: 99%

Prognostic Value of Reduced Left Ventricular Ejection Fraction at Start of Hemodialysis Therapy on Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients

Yamada

Ishii²,

Takahashi

et al. 2010

Clinical Journal of the American Society of Nephrology

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“…Several investigations consistently showed that OSA may contribute to the impair-ment of left-ventricular (LV) systolic function, leading to heart failure. [1][2][3] Echocardiography is the most common imaging modality used today to assess LV myocardial function; the most widely used clinical tool to quantify LV systolic function is the ejection fraction. However, most patients with OSA without other cardiovascular disease usually exhibit normal LV ejection fraction; nevertheless, they still may have subclinical LV systolic dysfunction.…”

Section: Introductionmentioning

confidence: 99%

A Novel Method for Sensitive Determination of Subclinical Left-Ventricular Systolic Dysfunction in Subjects With Obstructive Sleep Apnea

et al. 2015

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BACKGROUND: This study was to evaluate the subclinical left-ventricular (LV) systolic dysfunction with 2-dimensional speckle-tracking echocardiography in subjects with obstructive sleep apnea (OSA) with normal left ventricular ejection fraction and without any confounding disease that can cause myocardial dysfunction. METHODS: Nineteen healthy individuals and 60 subjects with OSA were included in this study. According to the severity of disease, OSA subjects were examined in 3 groups: mild, moderate, and severe OSA. LV apical views (for longitudinal strain) and short-axis views (for circumferential strain) were acquired for evaluation. Three-layer longitudinal strain values and circumferential strain values were determined for each view, and averages of these were used in comparison with other groups. RESULTS: Three-layer longitudinal strain values of the subjects with OSA were lower than those of the healthy individuals, and these values were decreased along with the OSA severity. The difference was significant between severe OSA and all other groups. Three-layer circumferential strain values of the OSA subjects were lower than those of the healthy individuals, and the difference was significant between the control group and all other groups. The apnea hypopnea index was found to be correlated with the 3-layer longitudinal strain (r ‫؍‬ ؊0.74, P < .001; r ‫؍‬ ؊0.72, P < .001; r ‫؍‬ ؊0.69, P ‫؍‬ <.001). CONCLUSIONS: Three-layer longitudinal and circumferential LV systolic functions in OSA subjects with normal left ventricular ejection fraction are deteriorated in the subclinical stage. Two-dimensional speckle-tracking echocardiography can be used as an effective method in the determination of subclinical myocardial dysfunction in subjects with OSA. Key words: obstructive sleep apnea; speckle-tracking echocardiography; myocardial strain. [Respir Care 2016;61(3):366 -375.

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“…4 Obstructive sleep apnea affects both ventricles and is associated with impaired ventricular function. 5,6 Noninvasive echocardiographic indices of systolic and diastolic ventricular function are of great clinical importance in the diagnosis and treatment of patients who have heart disease. The tissue-Doppler myocardial performance index (TD-MPI) has been proposed as a measure of overall cardiac function.…”

mentioning

confidence: 99%

Biventricular Myocardial Performance Is Impaired in Proportion to Severity of Obstructive Sleep Apnea

Akyol¹,

Çörtük²,

Baykan³

et al. 2016

Texas Heart Institute Journal

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Left Ventricular Systolic Dysfunction in Patients with Obstructive Sleep Apnea Syndrome

Cited by 155 publications

References 26 publications

Prognostic Value of Reduced Left Ventricular Ejection Fraction at Start of Hemodialysis Therapy on Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients

Prognostic Value of Reduced Left Ventricular Ejection Fraction at Start of Hemodialysis Therapy on Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients

A Novel Method for Sensitive Determination of Subclinical Left-Ventricular Systolic Dysfunction in Subjects With Obstructive Sleep Apnea

Biventricular Myocardial Performance Is Impaired in Proportion to Severity of Obstructive Sleep Apnea

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