Most cities worldwide suffer from serious air-quality problems, which have received increasing attention in the past decade. The most probable reason for the air-quality problems is the urban population growth, combined with a change in land use due to increasing urban areas. The emission of air pollutants is caused by different anthropogenic processes which can be categorized into the sources of urban traffic, industry, and domestic heating. Dispersion and dilution of air pollutants are strongly influenced by meteorological conditions, especially by wind direction, wind speed, turbulence, and atmospheric stability. With an increasing number of people living in cities, there is the need to examine the correlation between air pollution, local climate, and the effects these changes have on global climate. New interdisciplinary research studies are needed to increase our understanding of the interactions among these aspects. The aim is to analyze the pollutant condition in Rome and the other provinces of the Lazio region with qualitative and quantitative analysis, in order to understand which are the main pollutant sources and what is the correlation of habits of the population on air pollutant emissions.