Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial

Ihme, N.; Kiesewetter, H.; Jung, Fritz; Hoffmann, Klaus H.; Birk, A. O.; Müller, A.R; Grützner, Karen I.

doi:10.1007/s002280050138

Cited by 112 publications

(48 citation statements)

References 10 publications

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“…A hundred µmol L -1 of rutin also induced apoptosis in human glioblastoma cells by affecting the cell cycle (11). Rutin possesses anti-inflammatory (inhibiting the mucosal content of platelet-activating factor, PAF) and vasoactive activity (diminishing capillary permeability) as well as antioxidant activity (scavenging of hydroxyl and superoxide radicals) (12). Also, anti-carcinogen activity of rutin against prostate, breast, lung and colon cancers was demonstrated (13,14).…”

Section: +mentioning

confidence: 98%

Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells

Karakurt

2016

Acta Pharmaceutica

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Expression of a drug and xenobiotic metabolizing enzymes, cytochrome P450s (CYPs), and antioxidant enzymes can be modulated by various factors. The flavonoid rutin was investigated for its anti-carcinogen and protective effects as well as modulatory action on CYPs and phase II enzymes in human hepatocellular carcinoma cells. Rutin inhibited proliferation of HEPG2 cells in a dose-dependent manner with the IC 50 value of 52.7 µmol L -1 and invasion of HEPG2 cells (21.6 %, p = 0.0018) and colony formation of those invaded cells (57.4 %, p < 0.0001). Rutin treatment also significantly increased early/late-stage apoptosis in HEPG2 cells (28.9 %, p < 0.001). Treatment by rutin significantly inhibited protein expressions of cytochrome P450-dependent CYP3A4 (75.3 %, p < 0.0001), elevated CYP1A1 enzymes (1.7-fold, p = 0.0084) and increased protein expressions of antioxidant and phase II reaction catalyzing enzymes, NQO1 (2.42-fold, p < 0.0001) and GSTP1 (2.03-fold, p < 0.0001). Besides, rutin treatment significantly inhibited mRNA expression of CYP3A4 (73.2 %, p=0.0014). Also, CYP1A1, NQO1 and GSTP1 mRNA expressions were significantly increased 2.77-fold (p = 0.029), 4.85-fold (p = 0.0051) and 9.84-fold (p < 0.0001), respectively.

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Section: +mentioning

confidence: 98%

Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells

Karakurt

2016

Acta Pharmaceutica

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“…In Shanxi province, China, both common (Fagopyrum esculentum) and tartary (Fagopyrum tataricum) buckwheats are used to improve the health of patients with diabetes and cardiovascular diseases (Wieslander et al 2000). A previous experimental buckwheat study concluded that intake of common buckwheat leaf tea could prevent further development of leg edema (Ihme et al 1996), and a study by He et al (1995) showed a cholesterol-lowering effect of buckwheat. However, there are very few studies on the health effects of buckwheat, especially buckwheat products in humans.…”

Section: Tohoku University Medical Pressmentioning

confidence: 99%

Eating Buckwheat Cookies Is Associated with the Reduction in Serum Levels of Myeloperoxidase and Cholesterol: A Double Blind Crossover Study in Day-Care Centre Staffs

Wieslander

Fabjan

Vogrincic

et al. 2011

Tohoku J. Exp. Med.

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Buckwheat food is a good source of antioxidants, e.g. rutin, and other beneficial substances. Here we investigated the effects of the intake of common buckwheat (low rutin content) and tartary buckwheat cookies (high rutin content) on selected clinical markers. A double blind crossover study was performed among female day-care centre staffs (N = 62) from five day-care centres. Participants were randomly divided into two groups. The first group initially consumed four common buckwheat cookies per day (16.5 mg rutin equivalents/day) for two weeks, while the second group consumed four tartary buckwheat cookies per day (359.7 mg rutin equivalents/day). Then the groups switched their type of cookies and consumed them for another two weeks. We monitored selected clinical markers related to cardiovascular disease and lower airway inflammation, lung function, and subjective breathing difficulties in the staffs. Intake of tartary buckwheat cookies reduced the serum level of myeloperoxidase (MPO) by a factor 0.84 ( p = 0.02). When grouping the two types of buckwheat cookies together, there was a reduction of total serum cholesterol ( p < 0.001) and HDL-cholesterol ( p < 0.001) during the study period, with improved lung vital capacity ( p < 0.001). The degree of reduction in total and HDL cholesterol levels was similar in staffs with low and high body mass index (cut off 25). In conclusion, intake of tartary buckwheat cookies with high level of the antioxidant rutin may reduce levels of MPO, an indicator of inflammation. Moreover, intake of both types of buckwheat cookies may lower cholesterol levels.Keywords: antioxidant experiment; buckwheat; cholesterol; inflammation; lung function Tohoku J. Exp. Med., 2011, 225 (2), 123-130. © Tohoku University Medical PressThere is an increased interest in the beneficial health effects of dietary antioxidants intake, because they can help to prevent different types of diseases. Buckwheat is a good source of antioxidants, biologically high-valued amino acids (Krkoškova and Mrazova 2005;Jiang et al. 2007), dietary fiber (Bonafaccia et al. 2003), and minerals such as zinc, copper and manganese (Ikeda and Yamashita 1994). In Shanxi province, China, both common (Fagopyrum esculentum) and tartary (Fagopyrum tataricum) buckwheats are used to improve the health of patients with diabetes and cardiovascular diseases (Wieslander et al. 2000). A previous experimental buckwheat study concluded that intake of common buckwheat leaf tea could prevent further development of leg edema (Ihme et al. 1996), and a study by He et al. (1995) showed a cholesterol-lowering effect of buckwheat. However, there are very few studies on the health effects of buckwheat, especially buckwheat products in humans. Japanese studies indicate that some of the beneficial effects of buckwheat may be related to the low digestibility of buckwheat (Ikeda and Yamashita 1994). Skrabanja et al. (2001) reported beneficial effects of starch in common buckwheat with respect to insulin response. Buckwheat is also a good source of r...

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“…[2][3][4] In addition, high contents of bioactive substances such as flavone-like compounds have showed significant effects in preventing diseases such as diabetes, hypertension, arthritis, etc. 5,6) But buckwheat can also cause allergy and even anaphylaxis in a few subjects. [7][8][9] The first report about buckwheat hypersensitivity was published in 1909.…”

mentioning

confidence: 99%

Cloning, Expression, and Identification of Immunological Activity of an Allergenic Protein in Tartary Buckwheat

Wang

Chang

et al. 2006

Bioscience, Biotechnology, and Biochemistry

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Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial

Abstract: CVI is a very placebo-sensitive condition. The treatment with buckwheat herb tea is safe and could have a favourable influence on patients with CVI such that further oedema development is prevented.

Cited by 112 publications

References 10 publications

Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells

Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells

Eating Buckwheat Cookies Is Associated with the Reduction in Serum Levels of Myeloperoxidase and Cholesterol: A Double Blind Crossover Study in Day-Care Centre Staffs

Cloning, Expression, and Identification of Immunological Activity of an Allergenic Protein in Tartary Buckwheat

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