Leg Pain in a Patient with Myasthenia Gravis

Abstract

K E Y W O R D S :No ca r di a ; m y a s th en ia g r a v is ; pre dn is on e; immunocompromised. J Gen Intern Med 28(11):1523 DOI: 10.1007/s11606-013-2445-x © Society of General Internal Medicine 2013A 79-year-old male with myasthenia gravis on chronic prednisone therapy presented with progressive left leg pain and swelling and nonproductive cough for one month. Physical examination was significant for multiple, irregular, tender areas of induration in his bilateral lower extremities without overlying erythema. Laboratory data were significant for a white cell count of 12,400/cmm. MRI showed multifocal abscesses in his bilateral lower extremities within the muscle beds, which were more significant on the left (Fig. 1). He underwent ultrasoundguided drainage of the large abscesses. Cultures grew Nocardia pseudobrasiliensis sensitive to moxifloxacin. CT chest showed bilateral pleural effusions and ground-glass opacities in the right upper lobe, suggesting pulmonary nocardiosis with dissemination secondary to immunosuppression from chronic steroid use. The patient was started on moxifloxacin with a plan to treat for 12 months.The majority of patients with nocardial infection are immunocompromised; the most common causes are glucocorticoid therapy, malignancy, organ transplantation, and HIV infection. Disseminated nocardial infection typically presents with deep abscess especially in the lower extremities or CNS. 1 Treatment requires a long course of therapy: 6 months for pulmonary or systemic nocardiosis and at least 12 months for immunocompromised patients. 2 Suspect norcardiosis in patients with CNS, soft tissue, or cutaneous lesions and a concurrent pulmonary process.

A case report of disseminated nocardiosis with ocular involvement in a myasthenia gravis patient and literature review

“…We performed the literature review by searching the MEDLINE database using the key words "nocardia," "nocardiosis, "and "myasthenia gravis." We found that up until our search, only 7 case reports of MG patients with nocardiosis had been reported [3][4][5][6][7][8][9]. To improve understanding of the disease process, we summarized the clinical characteristics of these patients, and these are listed in table 1.…”