Leg ulceration with associated thrombocytosis: healing of ulceration associated with treatment of the raised platelet count

Wirth, K; Schoepf, E.; Mertelsmann, R; Lindemann, A

doi:10.1046/j.1365-2133.1998.02141.x

Cited by 15 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the time the skin lesions developed, the myeloproliferative disorder was well controlled with hydroxyurea therapy: platelet or red blood cell counts were in the normal range. Contrary to the findings of Wirth et al, 11 leg ulcerations disappeared after cessation of hydroxyurea therapy and, paradoxically, there was an underlying blood dyscrasia parallel with thrombocytosis or polycythemia. Leg ulcers healed when blood dyscrasia appeared.…”

Section: Commentcontrasting

confidence: 55%

Leg Ulcers and Hydroxyurea

Sirieix¹,

Debure²,

Baudot³

et al. 1999

Arch Dermatol

124

108

View full text Add to dashboard Cite

Section: Commentcontrasting

confidence: 55%

Leg Ulcers and Hydroxyurea

Sirieix¹,

Debure²,

Baudot³

et al. 1999

Arch Dermatol

124

108

View full text Add to dashboard Cite

“…They argued that improvement of hemorheology by lowering the cell count allowed the wound to heal. Varma and Lanigan [27], however, replied that this effect might also be attributed to a change of medication during treatment: the patient of Wirth et al [26]was changed from HU to anagrelide. Kido et al [28]reported on a patient in whom HU was continued and the ulcer healed under prostaglandin E 1 and pentoxyfilline, two substances that act primarily on the microcirculation and hemorheology.…”

Section: Discussionmentioning

confidence: 99%

“…Myeloproliferative disorders can impair cutaneous microcirculation and hemorheology [1, 2, 24, 25]. Wirth et al [26]gave HU to a patient with chronic myelogenous leukemia who had a leg ulcer. The wound healed under cytotoxic treatment.…”

Section: Discussionmentioning

confidence: 99%

Leg Ulcers in Patients with Myeloproliferative Disorders: Disease- or Treatment-Related?

Bader

Banyai²,

Boni³

et al. 2000

Dermatology

View full text Add to dashboard Cite

Leg ulcers are a relatively frequent problem in patients with myeloproliferative disorders under treatment with hydroxyurea (HU). The pathogenesis is currently unknown and may be multifactorial. Concomitant arterial or venous disease may play a contributing role in the development of these wounds. Vasculitis, cryoglobulinemia and pyoderma gangrenosum should be considered if typical clinical signs are present. We report on 3 patients with myeloproliferative disorders who developed HU-induced leg ulcers and review the literature. HU-induced leg ulcers share clinical features which can help to differentiate them from leg ulcers of other etiologies: occurrence under long-term treatment with HU at a dose of at least 1 g/day, localization in the malleolar region and spontaneous healing when HU is discontinued. We conclude that differentiation between disease-related and treatment-induced leg ulcers can be difficult and may not always be possible. In HU-induced leg ulcers, cessation of the drug typically leads to wound healing.

show abstract

“…A less well-characterized complication is the leg ulcer. Until now several case reports on patients with a hydroxyurea-induced leg ulcer have been published, however, few papers were retrospective reviews based on a patient-population registered in one or more medical centers [4][5][6][7][8][9][10][11][12]. Less than 20% of the papers were published in haematological journals.…”

Section: Introductionmentioning

confidence: 99%

Leg ulcer in hydroxyurea-treated patients

Poros¹,

Nádasdy²

2000

Haematologia

View full text Add to dashboard Cite

A cutaneous ulcer is a lesser known complication of hydroxyurea treatment. Out of 39 patients [18 polycythaemia vera (PV), 13 essential thrombocythaemia (ET), 4 chronic myeloid leukemia (CML), 4 undefined myeloproliferative diseases (MPD)] treated with hydroxyurea, 6 (4ET, 1PV, 1CML) developed a cutaneous ulcer during a period of less that 2 years' treatment. In all but one of the patients the ulcers were situated in the ankle region. At the time of onset of ulceration, none of them had extreme values in their peripheral blood counts. All had one or more of the predisposing factors such as minor trauma or mild varicosity. None of the patients had any alteration in arterial or venous circulation when examined by non-invasive means. No hyperviscosity was found as measured by capillary viscosimeter. The ulcers were cured in three patients without discontinuation of the drug. One patient later developed an ulcer on the other leg. The ulcers healed in two patients only after having stopped the hydroxyurea medication. One patient still had the ulcer when she succumbed to the underlying CML in transformation. In conclusion, cutaneous, ulceration of the leg is relatively common during hydroxyurea therapy. Predisposing factors are also involved in its development. Its healing does not necessarily require the discontinuation of the drug.

show abstract

Leg ulceration with associated thrombocytosis: healing of ulceration associated with treatment of the raised platelet count

Cited by 15 publications

References 6 publications

Leg Ulcers and Hydroxyurea

Leg Ulcers and Hydroxyurea

Leg Ulcers in Patients with Myeloproliferative Disorders: Disease- or Treatment-Related?

Leg ulcer in hydroxyurea-treated patients

Contact Info

Product

Resources

About