Legacy of Vitamin D: Role of Vitamin D in Prevention of Gynecological Cancers

Attar, Rükset; Gasparri, Maria Luisa; Halim, Talha Abdul; Hamwi, Dana Al; Uçak, İlknur; Fayyaz, Sundas; Zaman, Farrukh; Farooqı, Ammad Ahmad

doi:10.1007/978-3-319-53082-6_1

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…The biological activity of SEMA3B results from its interaction with neuropilin receptors (NRP1 and NRP2), which leads to reduced secretion of vascular endothelial growth factor and inhibition of formation of new blood vessel networks through which nutrients and oxygen are supplied to the tumor mass [4,5]. The abnormal expression pattern of SEMA3B has been reported in breast cancer [4], ovarian cancer [6], hepatocellular carcinoma [7], lung cancer [8], and endometrial cancer [9]. Recent studies indicate that SEMA3B plays an important role in osteoporosis, where its reduced level is observed.…”

Section: Introductionmentioning

confidence: 99%

Expression of Semaphorin 3B (SEMA3B) in Various Grades of Endometrial Cancer

Dziobek

Opławski²,

Grabarek

et al. 2019

Med Sci Monit

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Background SEMA3B is known as an inhibitor of angiogenesis and cell proliferation. During carcinogenesis, the loss of SEMA3B function is observed, which results in the progression of neoplastic changes. The aim of this study was to evaluate the expression profile of SEMA3B in endometrial cancer (G1–G3) in comparison to the control group and to assess whether the observed changes in expression could become a molecular marker in endometrial cancer. Material/Methods The study group consisted of 45 patients diagnosed with endometrial cancer (G1, 17; G2, 15; G3, 13). The control group included 15 patients. SEMA3B expression was assessed using the immunohistochemical method. Statistical analysis was carried out using the Statistica 12 PL program (StatSoft, USA). It included the Kruskal-Wallis test and post hoc Dunn’s test (p<0.05). Results Statistically significant differences in the level of SEMA3B expression were observed between all analyzed groups. The expression pattern of SEMA3B was as follows: cancer cells G1>G2>G3; endothelial cells: G3>G1>G2; stromal cells: G2>G1>G3. Conclusions Analysis of the SEMA3B expression profile shows the complexity of neoplastic transformation, which confirms the different expression of SEMA3B in endometrial cancer cells and endothelial cells. The present results and data in the literature data suggest that SEMA3B expression indicates the progression of carcinogenesis in the context of endometrial cancer.

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Section: Introductionmentioning

confidence: 99%

Expression of Semaphorin 3B (SEMA3B) in Various Grades of Endometrial Cancer

Dziobek

Opławski²,

Grabarek

et al. 2019

Med Sci Monit

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“…Vitamin D and its receptor (VDR) play a crucial role in the development of gynecological cancers. The paradigm shift in our understanding of vitamin D as an anti-cancer agent has opened a new horizon to explore how transduction of intracellular signals triggers a group of cellular functions [2]. Vitamin D 1.25 (OH)2 is the active hormonal form of vitamin D. In-vitro studies have suggested various mechanistic pathways in which vitamin D inhibits cervical cancer proliferation and decreases the cervical cancer oncogene, HCCR-1, and increases p21 expression, thereby leading to cell cycle arrest at G1.…”

Section: Introductionmentioning

confidence: 99%

Comparison of VDR Expression and Blood Vitamin D 1.25 (OH)2 Level between Cervical Cancer Patients and Normal Women

Askandar

Ekaputra

Iskandar

2020

Indonesian Journal of Cancer

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Background: Vitamin D and its receptor (VDR) play a crucial role in the development of gynecological cancers. This study aims to evaluate the VDR expression and blood vitamin D 1.25 (OH)2 levels in cervical cancer patients and healthy women.Methods: This is a cross-sectional study. In vitro quantitative examination (ELISA) was used for the measurement of vitamin D 1.25 (OH)2 and Sandwich-ELISA was applied for quantitative determination in vitro concentration of Human VDR in serum.Results: The number of research subjects consisting of 20 cervical cancer patients based on clinical and histopathological results and 20 women without cervical cancer based on clinical and pap smear results. The mean vitamin D 1.25 (OH)2 levels in the cervical cancer group of 209.23 ± 71.476 pg/mL were significantly lower than in the group of normal women of 339.79 ± 139.003 pg/mL (P=.001). The mean VDR expression in the cervical cancer group of 5.38 ± 5.478 ng/mL was significantly higher than the group of normal women of 1.89 ± 1.657 ng/mL (P=.018). The best cut-off value for vitamin D levels is 239.25 pg/mL (sensitivity 70% and specificity 75%). The cut-off value for VDR expression is 2.23 ng/mL (sensitivity 60% and specificity 75%). Low vitamin D levels increase the risk of cervical cancer incidence by 2.7 times greater, and an increase in VDR expression increases the risk of cervical cancer incidence 2 times greater.Conclusions: The study results indicated a higher expression of VDR and lower levels of vitamin D 1.25 (OH)2 in cervical cancer compared to normal women. Low levels of vitamin D increase the risk of cervical cancer incidence by 2.7 times greater, and higher VDR expression increases the risk of cervical cancer incidence 2 times greater.

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Legacy of Vitamin D: Role of Vitamin D in Prevention of Gynecological Cancers

Cited by 2 publications

References 29 publications

Expression of Semaphorin 3B (SEMA3B) in Various Grades of Endometrial Cancer

Expression of Semaphorin 3B (SEMA3B) in Various Grades of Endometrial Cancer

Comparison of VDR Expression and Blood Vitamin D 1.25 (OH)2 Level between Cervical Cancer Patients and Normal Women

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