Legacy perfluoro-alkyl substances impair LDL-cholesterol uptake independently from PCSK9-function

Sabovic, Iva; Lupo, Maria Giovanna; Rossi, Ilaria; Pedrucci, Federica; Di Nisio, Andrea; Dall’Acqua, Stefano; Ferri, Nicola; Ferlin, Alberto; Foresta, Carlo; De Toni, Luca

doi:10.1016/j.toxrep.2023.09.016

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Chen et al, 2020 53 (Continued ) 81,[100][101][102] In the large studies, total serum PFAS and individual PFAS (PFOA, PFHxS, and PFOS) also were found to be associated with higher HDL-C, but in the small studies, PFOA was reported to be associated with lower HDL-C concentrations in exposed versus control participants or not associated with HDL-C. 81,[100][101][102] Total serum PFASs were not found to be associated with serum triglycerides, but PFOA and PFHxS (not PFNA or PFOS) were reported to be linked with increased serum triglycerides. 81,[100][101][102] Analysis of participants from a contaminated community in Sweden (3760 participants) also reported associations between PFOA, PFHxS, and PFOS and higher total cholesterol, LDL-C, and HDL-C. 103 Null associations were reported for PFAS and triglycerides. 103 Cross-sectional studies in North America have analyzed associations between PFAS and serum lipids in the general population and contaminated communities.…”

Section: Dyslipidemia and Atherosclerosismentioning

confidence: 99%

Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk

Schlezinger,

Gokce

2024

Circulation Research

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Conservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-forming foam utilized in firefighting. As such, our exposure to PFAS is essentially ubiquitous. Given the long half-lives of these degradation-resistant chemicals, virtually, all people are carrying a body burden of PFAS. Health concerns related to PFAS are growing such that the National Academies of Sciences, Engineering and Medicine has recommended standards for clinical follow-up of individuals with high PFAS blood levels, including prioritizing screening for dyslipidemia. The link between PFAS and dyslipidemia has been extensively investigated, and evidence for associations is compelling. However, dyslipidemia is not the only cardiovascular risk factor with which PFAS is associated. Here, we review the epidemiological evidence for links between PFAS of concern identified by the National Academies of Sciences, Engineering and Medicine and risk factors for cardiovascular disease, including overweight/obesity, glucose intolerance, hypertension, dyslipidemia, and hyperuricemia. Moreover, we review the potential connections of PFAS with vascular disease and atherosclerosis. While observational data support associations between the National Academies of Sciences, Engineering and Medicine PFAS and selected cardiac risk factors, additional research is needed to establish causation and better understand how exposure to PFAS leads to the development of these conditions.

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