Background and Purpose-Telestroke has been effective in the management of acute ischemic stroke. This study characterizes and compares stroke specialist (SS) and emergency physician (EP) perceptions of telestroke and identifies barriers preventing increased implementation. Methods-A survey was developed and distributed nationwide to 382 SSs through an online survey system and in paper form to 226 EPs attending the 2008 American College of Emergency Physicians national conference. Results-Stroke specialists perceived themselves to be more knowledgeable about telemedicine and telestroke (PϽ0.001and Pϭ0.010, respectively). A large majority of physicians in both specialties either strongly agreed or agreed that telestroke will reduce geographical differences in stroke management and that it is superior to telephone consultation. Key Words: acute stroke Ⅲ emergency medicine Ⅲ stroke care Ⅲ telemedicine Ⅲ telestroke T elestroke, real-time audio and visual communication between a stroke specialist (SS) and emergency physicians (EPs), has been proposed as a solution to low recombinant tissue plasminogen activator (rtPA) administration rates in acute ischemic stroke (AIS). 1,2 The technology is currently used by a number of hospital systems, both within the United States and internationally. 3,4 Studies show its advantages over traditional telephone consults. 4 Yet, despite its demonstrated safety and effectiveness in increasing rtPA administration rates, the technology has not been implemented in many hospitals that stand to benefit.We characterize and compare the attitudes, beliefs, and perceived barriers of SSs and EPs regarding the broader implementation of telestroke.