This chapter focuses on considerations for conducting open-system field experiments in the context of ocean alkalinity enhancement (OAE) research. By conducting experiments in real-world marine and coastal systems, researchers can gain valuable insights into ecological dynamics; biogeochemical cycles; and the safety, efficacy, and scalability of OAE techniques under natural conditions. However, logistical constraints and complex natural dynamics pose challenges. To date, only a limited number of OAE field studies have been conducted, and guidelines for such experiments are still evolving. Due to the fast pace of carbon dioxide removal (CDR) research and development, we advocate for openly sharing data, knowledge, and lessons learned as quickly and efficiently as possible within the broader OAE community and beyond. Considering the potential ecological and societal consequences of field experiments, active engagement with the public and other stakeholders is desirable, while collaboration, data sharing, and transdisciplinary scientific teams can maximize the return on investment. The outcomes of early field experiments are likely to shape the future of OAE research, implementation, and public acceptance, emphasizing the need for transparent and open scientific practices.