Preserving patient safety, patient rights, and safeguarding trust are crucial components for the provision of high-quality medical treatments across borders. This chapter focuses on required technological improvements to address quality challenges through the adoption of generic building blocks (BBs) towards enabling seamless care between European healthcare systems. The authors present important considerations that are relevant to incremental, cross-sectorial advancements for the enhancement of the technology used for the implementation of the directive on the application of patients' rights in cross-border healthcare. These include cross-domain technical BBs to support non-repudiation, capability lookup, dynamic service location, and electronic identification. The authors use cross-border electronic prescription and patient summary, as a case to discuss the use of related international interoperability standards, together with recommendations for future work relevant to the introduction of better quality, trustworthy, cross-border, electronic health services in Europe.