Legionella bozemanii

Sobel, Jack D.; Krieger, Richard; Gilpin, Richard W.; Griska, Linda; Agarwal, Pasha

doi:10.1001/jama.1983.03340030043026

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…few presidents were as outspoken on the need to protect the civil rights of black Americans as Calvin Coolidge." 85 There was nothing new about Coolidge's interest in human rights and his intertwining of those rights with the rule of law and democracy. As early as 1914, he urged the Massachusetts Senate to "[r]ecognize the immortal worth and dignity of man .…”

Section: Coolidge the Court And The Election Of 1924mentioning

confidence: 99%

Calvin Coolidge and the Supreme Court

Fowler

2000

Journal of Supreme Court History

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Section: Coolidge the Court And The Election Of 1924mentioning

confidence: 99%

Calvin Coolidge and the Supreme Court

Fowler

2000

Journal of Supreme Court History

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“…It is a well-known cause of pneumonia in immunocompromised hosts [4][5][6][7][8][9]. However, it is rarely reported in an immunocompetent host [10]. We describe the case of fatal legionella bozemanii in a previously healthy woman without known medical conditions.…”

Section: Introductionmentioning

confidence: 99%

A Fatal Case of Legionella bozemanii Pneumonia in an Immunocompetent Patient

Siddiqui

2024

Case Reports in Pulmonology

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Legionella bozemanii pneumonia is a rare form of Legionnaires’ disease caused by the bacterium Legionella bozemanii. It is well known to cause pneumonia in immunocompromised patients and has rarely been reported in immunocompetent hosts. We describe a case of a 59-year-old immunocompetent female presented with pneumonia, acute respiratory failure, acute respiratory distress, and septic shock, who was treated with azithromycin, goal-directed resuscitation, and extracorporeal membrane oxygenation (ECMO) but did not survive. Clinicians should have high suspicion of rare legionella pathogens as causative agents for pneumonia.

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“…In contrast to human sequencing diagnostics, infectious disease sequencing diagnostics generally require rapid and actionable results, sometimes within hours, as delayed or incorrect initial diagnoses can result in fatalities [1]. We are presenting a clinical scenario in which NGS technology, specifically the Karius test, was used to identify a subspecies of the Legionellaceae family, Fluoribacter bozemanae, causing severe pneumonia in an immunocompromised host [2,3]. The lack of effective commercially available diagnostic modalities for many of the different subspecies and serogroups of the Legionellaceae family poses a unique diagnostic challenge [4].…”

Section: Introductionmentioning

confidence: 99%

Next-Generation Sequencing of Microbial Cell-Free DNA to Rapidly Detect Fluoribacter Bozemanae Pneumonia in an Immunocompromised Host

Carlan

2023

JCMR

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Background: Fluoribacter bozemanae is an uncommon pathogen that accounts for just 3-5% of cases of pneumonia caused by the different Legionella species. The mortality rate has been reported to be up to 40%. This organism is difficult to identify, making diagnosis extremely challenging with current diagnostic modalities. Case Report: We present a case of a 75-year-old female with a history of multiple myeloma undergoing active treatment with immunosuppressive agents who presented with confusion, hypoxemic respiratory failure and sepsis. Her initial presentation was consistent with Legionella infection, however, all routine testing including a Legionella urine antigen test came back negative. A CT scan of the chest was completed which showed near complete left lower lobe consolidation concerning for pneumonia. An infectious workup was initiated. Atypical and viral pneumonia polymerase chain reaction panel was negative. Microbial cell-free DNA sequencing returned positive for Fluoribacter bozemanae, a subspecies of the Legionellaceae family that is known to cause severe pneumonia in immunocompromised hosts. This information allowed a therapy adjustment resulting in rapid improvement of our patient’s symptoms. Conclusion: In cases such as this one, the diagnosis of Legionella species is often missed due to the many challenges associated with the different testing modalities. In these circumstances, next-generation genetic sequencing can be extremely useful. Now with the increasing availability of next-generation sequencing as a microbiological diagnostic tool, we can diagnose many more infections that once would have gone undiagnosed and either untreated or delayed in treatment.

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Legionella bozemanii

Cited by 9 publications

References 6 publications

Calvin Coolidge and the Supreme Court

Calvin Coolidge and the Supreme Court

A Fatal Case of Legionella bozemanii Pneumonia in an Immunocompetent Patient

Next-Generation Sequencing of Microbial Cell-Free DNA to Rapidly Detect Fluoribacter Bozemanae Pneumonia in an Immunocompromised Host

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