Legionella pneumonia causing multiple cavitating pulmonary nodules in a 7-month-old infant.

Quagliano, Peter V.; Narla, Lakshmana Das

doi:10.2214/ajr.161.2.8333379

Cited by 15 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bacterial infections may produce multiple rounded pulmonary nodules or masses, with or without cavitation. This may occur from infection with Nocardia, Aspergillus, Legionella, Q fever, and M. tuberculosis [27][28][29].…”

Section: Imaging Of Pneumonia In Specific Patient Groupsmentioning

confidence: 99%

Imaging of pneumonia: trends and algorithms

2001

View full text Add to dashboard Cite

Pneumonia is one of the major infectious diseases responsible for significant morbidity and mortality throughout the world. Imaging plays a crucial role in the detection and management of patients with pneumonia. This review article discusses the different imaging methods used in the diagnosis and management of suspected pulmonary infections. The imaging examination should always begin with conventional radiography. When the results of routine radiography are inconclusive, computed tomography is mandatory. A combination of pattern recognition with knowledge of the clinical setting is the best approach to the pulmonary infectious processes.A specific pattern of involvement can suggest a likely diagnosis in many instances. In acquired immune deficiency syndrome patients, diffuse ground-glass and interstitial infiltrates are most commonly present in Pneumocystis carinii pneumonia whereas in the nonimmunosuppressed patients, a segmental lobar infiltrate is suggestive of a bacterial pneumonia. Round pneumonia is most often encountered in children than adults and is most often caused by Streptococcus pneumoniae. Different combinations of parenchymal and pleural abnormalities may be suggestive for additional diagnoses.When an infectious pulmonary process is suspected, knowledge of the varied radiographic manifestations will narrow the differential diagnosis, helping to direct additional diagnostic measures, and serving as an ideal tool for follow-up examinations.

show abstract

Section: Imaging Of Pneumonia In Specific Patient Groupsmentioning

confidence: 99%

Imaging of pneumonia: trends and algorithms

2001

View full text Add to dashboard Cite

show abstract

“…Cavitary lesions in Legionella pneumonia have been described in infants [ 7 , 8 ], in renal transplant patients [ 6 ], in adults with inflammatory/autoimmune diseases on immunosuppressive therapy [ 9 ], and in patients with primary immune disorders [ 10 ]. While immunosuppression appears to be an important component of the ability of Legionella to create extensive disease significant enough to cavitate, it is the suppression or depression of the acquired immune system and specifically defense against intracellular pathogens that is likely the key permissive factor.…”

Section: Discussionmentioning

confidence: 99%

Cavitary Legionella Pneumonia in AIDS: When Intracellular Immunity Failure Leads to Rapid Intrapulmonary Cavitation

Durrance

Min

Fabbri

et al. 2021

Case Reports in Pulmonology

View full text Add to dashboard Cite

Introduction. Legionella is a frequent cause of bacterial pneumonia in patients with AIDS. While multiple organisms have been associated with cavitary pneumonia in this population, Legionella has not. Clinical Case. A middle-aged woman with HIV-AIDS and severely depressed CD-4 count presented with one month of progressively worsening productive cough and dyspnea. Serial imaging showed focal consolidations which multiplied and cavitated over the subsequent days. Legionella urine antigen was positive, and appropriate treatment was continued for 3 weeks total. The patient recovered quickly, and follow-up imaging 8 weeks later showed near-resolution of all lesions. Discussion. Cavitary pneumonia secondary to Legionella has been seldom described, traditionally in the context of immunosuppressive therapy. Patients with AIDS and severely depressed CD4 counts have significantly compromised cell-mediated immunity. This case highlights the importance of consideration for legionellosis in rapidly progressing cavitary pneumonia, especially in patients with severely compromised cell-mediated immunity, including those with HIV-AIDS.

show abstract

“…Sharply demarcated peribronchovascular foci of consolidation intermingled with GGO also seem to be one of the most common abnormalities of Legionella pneumonia (Sakai et al 2007). Cavitary lung disease is relatively more common in immunocompromised patients, including some groups of solid-organ transplant patients and neonates (Di Stefano et al 2007;Quagliano and Das Narla 1993). Nevertheless, Famiglietti et al reported two cases of legionellosis with cavitation in children who had no known underlying disease or immunodeficiency (Famiglietti et al 1997).…”

Section: Radiographic Changesmentioning

confidence: 99%

Pathogenicity of the family Legionellaceae

Palusińska-Szysz

Cendrowska-Pinkosz

2009

Arch. Immunol. Ther. Exp.

View full text Add to dashboard Cite

The Legionellae are Gram-negative bacteria able to survive and replicate in a wide range of protozoan hosts in natural environments, but they also occur in man-made aquatic systems, which are the major source of infection. After transmission to humans via aerosols, Legionella spp. can cause pneumonia (Legionnaires' disease) or influenza-like respiratory infections (Pontiac fever). In children, Legionnaires' disease is uncommon and is mainly diagnosed in children with immunosuppression. The clinical picture of Legionella pneumonia does not allow differentiation from pneumonia caused by others pathogens. The key to diagnosis is performing appropriate microbiological testing. The clinical presentation and the natural course of Legionnaires' disease in children are not clear due to an insufficient number of samples, but morbidity and mortality caused by this infection are extremely high. The mortality rate for legionellosis depends on the promptness of an appropriate antibiotic therapy. Fluoroquinolones are the most efficacious drugs against Legionella. A combination of these drugs with macrolides seems to be promising in the treatment of immunosuppressed patients and individuals with severe legionellosis. Although all Legionella species are considered potentially pathogenic for humans, Legionella pneumophila is the etiological agent responsible for most reported cases of community-acquired and nosocomial legionellosis.

show abstract

Legionella pneumonia causing multiple cavitating pulmonary nodules in a 7-month-old infant.

Cited by 15 publications

References 8 publications

Imaging of pneumonia: trends and algorithms

Imaging of pneumonia: trends and algorithms

Cavitary Legionella Pneumonia in AIDS: When Intracellular Immunity Failure Leads to Rapid Intrapulmonary Cavitation

Pathogenicity of the family Legionellaceae

Contact Info

Product

Resources

About