Legionella-protozoa-nematode interactions in aquatic biofilms and influence of Mip on Caenorhabditis elegans colonization

Rasch, Janine; Krüger, Stefanie; Fontvieille, Dominique; Ünal, Can; Michel, R.; Labrosse, Aurélie; Steinert, Michael

doi:10.1016/j.ijmm.2016.05.012

Cited by 28 publications

(27 citation statements)

References 53 publications

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Section: Environmental Hosts Of L Pneumophilamentioning

confidence: 99%

“…When examining natural aquatic biofilms, L. pneumophila has been found with diverse Protists and metazoans, possibly as a parasite or as food (Abu Khweek & Amer, 2018; Abu Khweek et al, 2013; Rasch et al, 2016). Due to low detection of L. pneumophila in situ , infection of metazoans could not be determined (Rasch et al, 2016). Caenorhabditis elegans , a temperate soil nematode, has been shown to be a possible environmental reservoir of L. pneumophila (Brassinga et al, 2010; Rasch et al, 2016).…”

Section: Environmental Hosts Of L Pneumophilamentioning

confidence: 99%

“…Due to low detection of L. pneumophila in situ , infection of metazoans could not be determined (Rasch et al, 2016). Caenorhabditis elegans , a temperate soil nematode, has been shown to be a possible environmental reservoir of L. pneumophila (Brassinga et al, 2010; Rasch et al, 2016). Furthermore, in vitro studies using C. elegans from environmental samples demonstrated the ability of L. pneumophila to colonize this metazoan (Rasch et al, 2016), which opens the possibility that if other lower metazoans were examined, new environmental hosts or reservoirs of L. pneumophila may be identified.…”

Section: Environmental Hosts Of L Pneumophilamentioning

confidence: 99%

“…Caenorhabditis elegans , a temperate soil nematode, has been shown to be a possible environmental reservoir of L. pneumophila (Brassinga et al, 2010; Rasch et al, 2016). Furthermore, in vitro studies using C. elegans from environmental samples demonstrated the ability of L. pneumophila to colonize this metazoan (Rasch et al, 2016), which opens the possibility that if other lower metazoans were examined, new environmental hosts or reservoirs of L. pneumophila may be identified. Within the environmental sample, L. pneumophila was found to not be capable of in vitro infection of rotifera, copepod, or nauplius larvae (Rasch et al, 2016).…”

Section: Environmental Hosts Of L Pneumophilamentioning

confidence: 99%

“…Furthermore, in vitro studies using C. elegans from environmental samples demonstrated the ability of L. pneumophila to colonize this metazoan (Rasch et al, 2016), which opens the possibility that if other lower metazoans were examined, new environmental hosts or reservoirs of L. pneumophila may be identified. Within the environmental sample, L. pneumophila was found to not be capable of in vitro infection of rotifera, copepod, or nauplius larvae (Rasch et al, 2016). However, the exact species were not determined and thus does not exclude other members of those phyla, class, or other naupli.…”

Section: Environmental Hosts Of L Pneumophilamentioning

confidence: 99%

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Evasion of phagotrophic predation by protist hosts and innate immunity of metazoan hosts byLegionella pneumophila

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Kwaik

2018

Cellular Microbiology

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Summary Legionella pneumophila is a ubiquitous environmental bacterium that has evolved to infect and proliferate within amoebae and other protists. It is thought that accidental inhalation of contaminated water particles by humans is what has enabled this pathogen to proliferate within alveolar macrophages and cause pneumonia. However, the highly evolved macrophages are equipped more sophisticated innate defense mechanisms than protists, such as the evolution of phagotrophic feeding into phagocytosis with more evolved innate defense processes. Not surprisingly, the majority of proteins involved in phagosome biogenesis (~80%) have origins in the phagotrophy stage of evolution. There are a plethora of highly evolved cellular and innate metazoan processes, not represented in Protist biology, that are modulated by L. pneumophila; including TLR2 signaling, NF-κB, apoptotic and inflammatory processes, histone modification, caspases, and the NLRC-Naip5 inflammasomes. Importantly, L. pneumophila infects hemocytes of the invertebrate Galleria mellonella, kill G. mellonella larvae, and proliferate in and kill Drosophila adult flies and Caenorhabditis elegans. Although co-evolution with protist hosts has provided a substantial blueprint for L. pneumophila to infect macrophages, we discuss the further evolutionary aspects of co-evolution of L. pneumophila and its adaptation to modulate various highly evolved innate metazoan processes prior to becoming a human pathogen.

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