“…For example, recent health-related misinformation, coupled with uncertainty during the COVID-19 pandemic, has heightened the need for high-quality, objective evidence . In the US, clinicians, policymakers, and the public have continued to deliberate about many long-standing policy issues, including the costs of health care and prescription drugs; health disparities and racial, ethnic, and gender inequities; the opioid epidemic; Medicaid and the Affordable Care Act; access to abortion and reproductive services; and clinician workforce and well-being . Controversies have also arisen over previously established standards like vaccinations and drug approvals .…”