Leiomyoma of the cheek. Case report

Gerçeker, Muharrem; Anadolu, R. Yucel; Bulay, Orhan

doi:10.1016/s0901-5027(05)80355-8

Cited by 2 publications

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“…Essas características estão de acordo com os critérios descritos na literatura para a maioria das regiões, discordando apenas dos leiomiossarcomas de útero e de genitália externa feminina (Hornick;Fletcher, 2003;Miettinen;Fetsch, 2006). Muitos autores consideram o índice mitótico como principal característica indicativa de comportamento biológico em boca (Kelly;Harrigan, 1977;Yamamoto et al, 1983;Gerçeker et al, 1993;Loyola et al, 1999;Wertheimer-Hatch et al, 2000;Lloria-Benet et al, 2003;Sobral et al, 2004;Rodini et al, 2007;Reddy et al, 2011).…”

Section: Discussionunclassified

“…Não há critérios de malignidade definidos para tumores de músculo liso em boca. Muitos autores consideram o índice mitótico como principal característica indicativa de comportamento biológico (Kelly;Harrigan, 1977;Yamamoto et al, 1983;Gerçeker et al, 1993;Loyola et al, 1999;Wertheimer-Hatch et al, 2000;Lloria-Benet et al, 2003;Sobral et al, 2004;Rodini et al, 2007;Reddy et al, 2011).…”

Section: Critérios De Malignidadeunclassified

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Análise histológica e imuno-histoquímica de leiomiomas e leiomiossarcomas de boca

Prieto-Oliveira¹

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This study aimed to compare oral leiomyomas and leiomyosarcomas by means of histological and immunohistochemical analysis. Cases from the Stomatology Department, School of Dentistry at University of São Paulo were retrieved. For immunohistochemistry Ki67, p53 and PTEN markers were used. Smooth muscle actin was used to confirm the diagnosis. There were 13 smooth muscle tumors: 7 leiomyosarcomas, 4 angioleiomyomas and 2 solid leiomyomas. For morphological analysis, sections were evaluated for atypia, mitotic index and presence of necrosis.Immunohistochemical analysis of Ki67, p53 and PTEN expression was performed by counting 500 positive cells in the most representative areas. Most angioleiomyomas did not present atypia, mitosis or necrosis; mild atypia was found in two solid leiomyomas, one with 1 mitosis per 10 HPF. Atypia was found in all leiomyosarcomas, the mitotic index varied from 0 to 6 mitosis per 10 HPF, and necrosis was found in only one case. Ki67 expression was positive in one angioleiomyoma and 5 leiomyosarcomas, the remaining cases were negative. For p53, one solid leiomyoma was mildly positive and the other showed moderate positivity; most of angioleiomyomas were mildly positive and only one was negative; all leiomyosarcomas were positive, 2 with mild expression, 4 moderate and one intense. PTEN expression was negative in one solid leiomyoma and intensely positive in the other; all angioleiomyomas were positive, with 2 mildly positive and 2 moderately positive; 3 leiomyosarcomas presented moderate positivity and 3 intense, only one was negative. Our results suggest that ki67 and p53 are useful in the differentiation between leiomyoma and leiomyosarcoma. The same was not found for PTEN.

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