Leiomyoma of the Orbit and Periocular Region

Abstract

Leiomyoma should be considered in the differential diagnosis of a well-circumscribed mass lesion involving the orbit and periorbital region. Immunohistochemistry provides conclusive evidence to confirm the diagnosis.

Angioleiomyoma in the Orbital Apex: A Case Report

“…On the other hand, intraorbital angioleiomyomas are rare, and like intracranial angioleiomyoma, exhibit a male to female predominance of 4:1 [11]. Surgical excision is the treatment of choice for orbital angioleiomyoma and in case of incomplete excision, the patient should be followed closely since the tumor could re-grow even it is benign and could show newly developed symptoms [3]. Radiation therapy for remnant tumor is not recommended for it is radioresistant and even radiation may cause radiation-induced sarcoma [12].…”

“…Ladato described first of the orbital angioleiomyoma in 1896, and Nath and Shukla documented in the English-language medical literature for first time in 1963. Since then Arat et al reviewed orbital angioleiomyomas of 26 well-documented cases and additional 9 cases were reported whereafter [345678]. Among them five were displayed at orbital apex.…”

“…Four tumors were removed through lateral orbitotomy and one was through frontotemporal approach. Three of them were excised incompletely and only two were completely resected [3]. Conventionally, various surgical approaches have been tried to treat orbital apex lesion: a medial approach by external ethmoidectomy, an inferomedial approach via a transantral transethmoidal route, a supraorbital transcranial approach [16].…”

“…However, orbital angioleiomyomas are extremely rare, and to date, only 35 cases have been reported based on pathology in the literature [345678]. Among them, only 5 cases arose from orbital apex [3]. We herein report a case of angioleiomyoma located in the orbital apex which was successfully removed with simultaneous endoscopic and microscopic endonasal approaches.…”

“…Since angioleiomyoma was firstly described by Stout, over 500 cases were reported [2]. However, orbital angioleiomyomas are extremely rare, and to date, only 35 cases have been reported based on pathology in the literature [345678]. Among them, only 5 cases arose from orbital apex [3].…”