Leiomyoma of the prostate: A case report and systematic review

Abstract

PurposeIt is rare to find a large leiomyoma in the prostate, especially in that of a young man. This case report and systematic review provides additional information on the diagnosis, distinguishing features of imaging examinations, and treatment options.Patients and MethodsWe report on the case of a thirty-year-old man with a large leiomyoma of the prostate. MRI of the prostate revealed a round mass in the posterior lobe, 8.0 × 8.0 × 5.5 cm in size. With the assistance of laparoscopy, we resected the prostate mass completely and spared this organ. A systematic review was conducted utilizing the Preferred Reporting Items for Systematic Reviews (PRISMA) including English language published reports, from 1970 to December 2021.ResultsUrinary and erectile functioning was preserved postoperatively. After a year of follow-up, no evidence of recurrence emerged. A total of 21 studies were included for analysis.ConclusionsA medical history of no, or few, lower urinary tract symptoms; the characteristics of a benign tumor in imaging examinations; and negative tumor markers should be included in any differential diagnosis of leiomyoma of the prostrate. A prostate biopsy should be performed before the preparative radical prostatectomy and choose nonsurgical treatment to confirm the diagnosis. Nowadays, minimally invasive surgery is the preferred effective option for this disease. It is a rare recurrence after its removal by means of surgery.

Leiomyoma of the Prostate Treated via Holmium Laser Enucleation: A Case Report and Literature Review

“…Immunohistochemically, leiomyomas are strongly positive for myogenic markers such as desmin and actin [ 4 ]. Furthermore, unlike stromal tumors of unknown malignant potential, CD34 is not expressed [ 1 ]. Our case was consistent with these findings.…”

“…Leiomyoma is a rare benign prostatic tumor that originates from smooth muscle cells within the prostate gland. Typically, its management includes endoscopic, surgical, and transarterial embolization therapies [ 1 ]. In a previous case, a patient was treated with holmium laser enucleation of the prostate (HoLEP) [ 2 ].…”

Angioleiomioma prostático associado a Adenocarcinoma Acinar Usual: um relato de caso

“…11,13,14,30 É notório que há carência de trabalhos na literatura atual acerca de tumores mesenquimais prostáticos, especialmente os benignos, haja vista a raridade dessas lesões. O presente relato de caso, acompanhado de relatos de outras lesões mesenquimais prostáticas raras, como por exemplo o leiomioma 6,7 , pode incentivar os patologistas a conferirem uma maior atenção a essas lesões durante o exame histopatológico. Estes tumores inclusive podem coexistir com adenocarcinomas prostáticos e passarem despercebidos, sendo subdiagnosticados.…”

“…2,3 Existem poucos relatos de caso de tumores mesenquimais prostáticos benignos na literatura, alguns relacionados por exemplo ao leiomioma, hemangioma e a tumores de células granulares. [5][6][7] Neoplasias mesenquimais da próstata também podem ser malignas ou de comportamento maligno incerto, contribuindo para um grande número de diagnósticos diferenciais. [2][3][4]8,9 As lesões mesenquimais são derivadas do estroma prostático intrínseco ou de outros tecidos associados como musculatura lisa, vasos sanguíneos, estruturas neurais ou partes moles adjacentes à próstata.…”