Leiomyoma with atypical cells (atypical leiomyoma) in the larynx

Matsumoto, Takeshi; Nishiya, Masahiro; Ichikawa, Ginichiro; Fujii, Hiroaki

doi:10.1111/j.1365-2559.1999.00645.x

Cited by 8 publications

(4 citation statements)

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“…If inflammatory myofibroblastic tumours of the larynx are definitely a neoplastic lesion, the possibility of these tumours, as in the diagnosis of our reported case, cannot be completely denied. On the other hand, intersecting fascicles of spindle cells having acidophilic cytoplasm with blunt‐ended nuclei in many areas and immunohistochemical positivity of desmin in the spindle cells, which suggested the leiomyogenic rather than myofibroblastic lesion, were noted in our reported case 1 . Finally, the pathological and genetic findings mentioned above led us to the conclusion that our reported case should be diagnosed as atypical leiomyoma.…”

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Matsumoto¹,

Nishiya

Ichikawa

et al. 2000

Histopathology

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“…Sir : We appreciate Dr Kendall's interest in our article 1 1 . A densely cellular and uniform proliferation with numerous atypical cells, sparse inflammatory cell infiltrate, abnormal p53 expression and multiple allelic losses indicated a neoplastic nature.…”

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Authors' reply

Matsumoto¹,

Nishiya

Ichikawa

et al. 2000

Histopathology

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“…In addition, if videolaryngoscopy reveals a smooth surface and no new organisms with a pedicle, no biopsy should be taken to avoid bleeding[ 6 , 9 ]. The diagnosis is based on histologic examination and confirmed by immunohistochemistry[ 8 , 10 ]. Recurrence after complete resection is rare[ 11 ], and only 2 studies report recurrence after surgery in patients diagnosed with laryngeal LMs[ 1 , 5 , 11 ].…”

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Laryngeal leiomyoma: A case report and review of literature

Wu,

Li,

Zhang

et al. 2024

World J Clin Cases

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BACKGROUND Leiomyomas (LMs) are mesenchymal tumors that arise from smooth muscle cells. LMs most commonly arise in organs with an abundance of smooth muscle such as the uterus and gastrointestinal tract. Conversely, LMs are rarely detected in the head and neck region. In this study, we report a rare case of laryngeal LM (LLM) and summarized the clinical characteristics of reported LLMs to help clinicians better understand this rare disease and improve its diagnosis, treatment, and postoperative course. CASE SUMMARY A 49-year-old man was admitted to our ENT outpatient clinic with a chief complaint of pharynx discomfort for 2 months. Laryngoscopy performed under topical anesthesia revealed a solitary, pink mass at the tubercle of epiglottis. Surgery via laryngeal endoscopy was performed under general anesthesia, and the lesion was excised easily. Positive immunohistochemical staining for desmin and smooth-muscle actin indicated a smooth muscle origin and the diagnosis was laryngeal leiomyoma. After surgery, the patient’s condition was stable, and he was discharged 2 d after surgery. During the 1-year postoperative period, the patient’s condition remained stable without evidence of recurrence. CONCLUSION Surgical resection is the preferred treatment for LLMs, its early diagnosis and differential diagnosis have important clinical significance.

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“…Sir : I was interested in the report ‘Leiomyoma with atypical cells (atypical leiomyoma) in the larynx’ by Matsumoto et al 1 2 .…”

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