Leiomyomatosis peritonealis disseminata: An unusual presentation

Meneni, R. D.; Farrow, Amy; Fawzi, H. W.

doi:10.3109/01443610903477549

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…Summarising the case reports and series, a total of 69 women with parasitic myoma after laparoscopic morcellation were identified. Data of all case reports and series are presented in the Supplementary material (Table S1) . The mean age at diagnosis was 40.8 (± 7.5) years (range 24–57) and the majority of the women were premenopausal ( n = 59; 85.5%).…”

Section: Resultsmentioning

confidence: 99%

Parasitic myoma after laparoscopic morcellation: a systematic review of the literature

Meulen

Pijnenborg

Boomsma

et al. 2015

BJOG

106

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Background Laparoscopic morcellation is frequently used for tissue removal after laparoscopic hysterectomy or myomectomy and may result in parasitic myomas, due to seeding of remained tissue fragments in the abdominal cavity. However, little is known about the incidence and risk factors of this phenomenon.Objectives To identify the incidence and risk factors for the development of parasitic myoma after laparoscopic morcellation.Search strategy A systematic review of the literature in Pubmed (MEDLINE) and Embase was conducted. Reference lists of identified relevant articles were checked for missing case reports.Selection criteria Studies reporting on incidence or cases of parasitic myoma diagnosed after laparoscopic morcellation were selected. Studies were excluded when history of laparoscopic morcellation was lacking or final pathology demonstrated a malignancy or endometriosis.Data collection and analysis Data were extracted and analysed on incidence of parasitic myomas and characteristics of case reports.Main results Fourty-four studies were included. Sixty-nine women diagnosed with parasitic myomas after laparoscopic morcellation were identified. Mean age was 40.8 (AE 7.5) years (range 24-57), median time between surgery and diagnosis was 48.0 months (range 1-192) and mean number of parasitic myomas was 2.9 (AE 3.3) (range 1-16). The overall incidence of parasitic myomas after laparoscopic morcellation was 0.12-0.95%.Conclusion Although the incidence is relatively low, it is important to discuss the risk of parasitic myoma after laparoscopic morcellation with women and balance towards alternative treatment options. The duration of steroid exposure after laparoscopic morcellation might be a risk factor for development of parasitic myomas.

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Section: Resultsmentioning

confidence: 99%

Parasitic myoma after laparoscopic morcellation: a systematic review of the literature

Meulen

Pijnenborg

Boomsma

et al. 2015

BJOG

106

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“…Lertvikool, 2015 119 Lurie, 1991 137 Mahmoud, 2015 74 Makris, 2012 54 Meneni, 2010 120 Mieli, 2013 88 Miyake, 2009 121 Moon, 2008 78 Mueller, 2012 47 Munshi, 2014 122 Nagase, 2012 123 Nappi, 2004 124 Nausheen, 2013 14 Nimaroff, 2010 111 Odofin, 2004 103 Okoro, 2007 96 Ordulu, 2010 67 Ostrzenski, 1997 79 Pallavee, 2014 89 Park, 2013 41 Patel, 2013 125 Paul, 2006 20 Payyapilly, 2010 69 Pezzuto, 2010 70 Phupong, 2003 22 Poliquin, 2008 77 Puga, 2013 109 Putran, 2010 126 Rabischong, 2013 90 Rader, 1990 53 Ribic-Pucelj, 2013 91 Salfelder, 2009 127 Shakir, 2012 128 Shepperd, 2012 72 Singh, 2013 129 Sinha, 2007 64 Sinha, 2009 13 Sizzi, 2007 33 Soliman, 2011 130 Tadayon, 2012 131 Takeda, 2007 61 Takeda, 2012 102 Takeda, 2013 62 Tan, 2012 45 Tanaka, 2009 35 Temizkan, 2014 …”

mentioning

confidence: 99%

Parasitic leiomyomas: a systematic review

Lete

González

Ugarte

et al. 2016

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Hormonal suppressive therapy is seldom used after surgery for iatrogenic LPD with only six cases reported (18)(19)(20)(21)(22)(23). One had recurrence 2 years later (23) and the follow-up period of the remaining cases was too short for meaningful evaluation of therapeutic effects.…”

Section: Discussionmentioning

confidence: 99%

Leiomyomatosis Peritonealis Disseminata Following Laparoscopic Surgery With Uncontained Morcellation: 13 Cases From One Institution

et al. 2021

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Objectives: To investigate the clinical characteristics, treatment and prognosis of leiomyomatosis peritonealis disseminata (LPD) following laparoscopic surgery with uncontained morcellation and to summarize clinical features of iatrogenic LPD based on published literature together with our own experience.Methods: A cohort of 13 cases with iatrogenic LPD diagnosed and treated in Peking Union Medical College Hospital from 2011 to 2020 was reported focusing on clinical characteristics, treatment and prognosis.Results: All the patients had a history of laparoscopic myomectomy with uncontained morcellation. The average age was 35.6 (range 25–47) years. The interval between initial laparoscopic surgery and first diagnosis of LPD was 6.08 years on average (range 1–12). Most of the patients had no obvious symptoms. The accuracy of pre-operative diagnosis was low. Two patients had been treated with gonadotropin-releasing hormone agonist (GnRH-a) before surgery without obvious effect. The nodules of LPD are usually located in the lower half of the peritoneal cavity. The most commonly involved site was the pouch of Douglas. The number of nodules ranged from 3 to over 10, and they ranged in size ranged from 0.3 to 22 cm. All patients underwent surgical treatment: six patients underwent laparoscopy and seven underwent laparotomy. Pathology results confirmed LPD. The immunohistochemical profile indicated LPD tends to be positive strongly for desmin, caldesmon, ER, PR and SMA. Only one patient underwent post-operative treatment with GnRH-a. All patients were followed for an average period of 49 months without recurrence.Conclusion: Iatrogenic LPD is a relatively rare condition. Patients usually exhibit no hormonal stimulation factors. Surgery is the main method of treatment, and hormone suppressive therapy is only rarely used. The nodules are usually large and less numerous, and most involve the pelvis. The prognosis of iatrogenic LPD seems good.

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Leiomyomatosis peritonealis disseminata: An unusual presentation

Cited by 8 publications

References 7 publications

Parasitic myoma after laparoscopic morcellation: a systematic review of the literature

Parasitic myoma after laparoscopic morcellation: a systematic review of the literature

Parasitic leiomyomas: a systematic review

Leiomyomatosis Peritonealis Disseminata Following Laparoscopic Surgery With Uncontained Morcellation: 13 Cases From One Institution

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