Leiomyomatosis peritonealis disseminata of unusual course with malignant transformation: case report

Żyła, Monika; Dzieniecka, Monika; Kostrzewa, Marta; Stetkiewicz, Tomasz; Wilamowska, Agnieszka; Księżakowska-Łakoma, Kinga; Wilczyński, Jacek R.

doi:10.1111/aogs.12549

Cited by 23 publications

(24 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The current literature on the subject does not mention patients who were previously treated with laparoscopy, and there are only limited records of benign leiomyoma implants to the peritoneum occuring after such procedures [30]. This independence of the disease, from the type of primary surgery, argues against the haematogenous spread of a uterine leiomyoma.…”

Section: Discussionmentioning

confidence: 99%

Benign metastasizing leiomyoma: A review of current literature in respect to the time and type of previous gynecological surgery

Książek²,

et al. 2017

View full text Add to dashboard Cite

IntroductionBenign metastasizing leiomyoma (BML) is a rare disorder that affects women with a history of uterine leiomyoma, which is found to metastasise within extrauterine sites. The aetiology of BML remains unexplained. Because BML is rare, and most publications contain descriptions of single cases, no statistically determined time relations were found between the primary and secondary surgeries, which may have aetiological implications.ObjectivesTo determine age before BML surgery, age during diagnosis of BML, type of prior surgery, and location of metastasis based on the literature.MethodsA systematic review of four databases (Medline/PubMed, Embase, Web of Science, and Cochrane) covering articles published from 1 January 1965 to 10 April 2016. The inclusion criteria were full-text articles in English and articles containing case reports. Articles in languages other than English (39), articles containing incomplete data (14), i.e. no information regarding the time of surgery and/or the site of metastasis, articles bereft of case studies (25), and articles with access only to summaries, without access to the complete text (10) were excluded. Of 321 titles identified, only 126 articles met the aforementioned criteria.Results and conclusionsThe mean age during primary surgery and BML diagnosis was 38.5 years and 47.3 years, respectively. The most common surgery was total hysterectomy. The most frequent site of metastasis was the lungs; other organs were affected less frequently.The site of metastases and their number were not related to the longer time span between the patient’s initial surgery and occurrence of metastasis. The analysed data, such as the age during primary surgery, age during BML diagnosis, site and type of metastasis, do not provide us a clear answer. Thus, BML pathogenesis is most probably complex in nature and requires further multidirectional research.

show abstract

Section: Discussionmentioning

confidence: 99%

Benign metastasizing leiomyoma: A review of current literature in respect to the time and type of previous gynecological surgery

Książek²,

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Cases of disseminated peritoneal leiomyomatosis after robotic, laparoscopic and open+ power morcellation have been reported (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). These tumors may be found incidentally during surgery and are often diffuse throughout the abdomen, involving multiple structures; therefore an intra operative consultation may be required.…”

Section: Resultsmentioning

confidence: 99%

“…Cases of recurrence with continued exposure to hormones such as during pregnancy, OCP and hormone replacement therapy have been reported. The risk for recurrence [33], metastasis [34], colonic obstruction [35], impaired quality of life, obstetric complications, and possible malignant transformation [22][23][24][25][26] underlines the importance of accurate diagnosis, facilitating patient specific treatment.…”

Section: Resultsmentioning

confidence: 99%

“…As these tumors are normally discovered as an incidental finding, histology and peritoneal washing play an important role in diagnosis and ruling out malignancy. DPL tumors are traditionally considered benign but several cases of malignant transformation have been reported, many occurring after surgical treatment [18][19][20][21][22][23][24][25][26]. In this case, a portion of the tumor was resected and sent for pathological analysis prior to follow up and further management.…”

Section: Discussionmentioning

confidence: 99%

“…These include avoiding oral contraceptives (OCP) and hormone replacement therapy (HRT) [10], administering gonadotropin releasing hormone agonist aromatase inhibitor therapy [28,29] and avoiding pregnancy . Without proper treatment, DPL can cause complications such as pain, bleeding, chronic constipation and infertility [17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Therefore management of DPL should be patient centered in order to achieve the specific treatment goals for each patient depending on their future plans for pregnancy.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Disseminated Peritoneal Leiomyomatosis (DPL); A Case Report and Review of Literature

Rezai¹

2017

OGIJ

View full text Add to dashboard Cite

Background: Disseminated peritoneal leiomyomatosis (DPL) also known as leiomyomatosis peritonealis disseminate (LPD) is a rare condition described as multiple smooth muscle tumors disseminated throughout the peritoneum, omentum and pelvic structures. Since first being described in 1952, less than 150 cases have been reported in English literature. However, the incidence of DPL may be under estimation as many cases are asymptomatic. The lesions occur most commonly in women of child bearing age and may have an association with oral contraceptive therapy (OCP) or hormone replacement therapy (HRT). These diffuse tumors are usually incidentally found during surgery but women may present with abdominal pain prompting investigation. This condition is rarely reported; therefore we describe a case of DPL in a 35 year old woman incidentally found during cesarean delivery.

show abstract

Disseminated peritoneal leiomyomatosis as an incidental finding: A case report

Morgan

Kahiye

Kule³

et al. 2022

Clinical Case Reports

View full text Add to dashboard Cite

We present the case of a 23‐year‐old female with multiple diffuse and nodular masses of different sizes involving predominantly the posterior wall of the uterus, omentum, and peritoneum which were histopathologically confirmed to be disseminated peritoneal leiomyomatosis. Meticulous investigation and accurate diagnosis are of utmost importance for the establishment of the correct diagnosis. Additionally, proper management of the patient while considering choice of the patients including close follow‐up of the patients is mandatory for the reason of ensuring early detection of recurrence.

show abstract

Leiomyomatosis peritonealis disseminata of unusual course with malignant transformation: case report

Cited by 23 publications

References 9 publications

Benign metastasizing leiomyoma: A review of current literature in respect to the time and type of previous gynecological surgery

Benign metastasizing leiomyoma: A review of current literature in respect to the time and type of previous gynecological surgery

Disseminated Peritoneal Leiomyomatosis (DPL); A Case Report and Review of Literature

Disseminated peritoneal leiomyomatosis as an incidental finding: A case report

Contact Info

Product

Resources

About