Leiomyosarcoma of Inferior Vena Cava

Cope, J. S.

doi:10.1001/archsurg.1954.01260050754004

Cited by 38 publications

(8 citation statements)

References 2 publications

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“…Recurrent disease following almost-complete and complete resection was treated with resection, chemotherapy, radiation therapy, or a combination. Surgical excision of solitary metastasis or dubulking of intraabdominal recurrence offered good palliation and achieved survival ranging from 12 to 90 months [10,11,24,25,52,58,63].…”

Section: Treatmentmentioning

confidence: 99%

Leiomyosarcoma of the inferior vena cava: A clinicopathologic review and report of three cases

et al. 1997

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Background and Objectives We operated on three patients with leiomyosarcoma of the inferior vena cava. Methods Complete excision was possible in all three patients. Results One patient developed widespread metastasis at 23 months, one patient is alive with no evidence of disease at 70 months, and one patient is alive at 15 months. The third patient had subcutaneous and pulmonary metastases at the time of presentation, which are radiologically nondetectable at present following postoperative chemotherapy. Conclusions The clinicopathologic features, prognostic factors, and treatment of 130 cases found in a comprehensive literature search and our three cases are reported. J. Surg. Oncol. 1997;65:205–217. © 1997 Wiley‐Liss, Inc.

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Section: Treatmentmentioning

confidence: 99%

Leiomyosarcoma of the inferior vena cava: A clinicopathologic review and report of three cases

et al. 1997

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“…Although leiomyosarcomas of the inferior vena cava are of relatively low malignant potential, local recurrence has been reported in 36% of patients with resectable tumor [52]. Leiomyosarcomas are poorly radiosensitive, and they often recur locally when adjuvant radiation therapy to the tumor bed is used after surgical resection.…”

Section: Managementmentioning

confidence: 99%

Primary leiomyosarcoma of the inferior vena cava: A case report and review of the literature

Griffin

Sterchi

1987

Journal of Surgical Oncology

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Sixty-six cases of leiomyosarcoma of the inferior vena cava (IVC) have been reported. We present another case and review the characteristics and treatment of this rare tumor. IVC leiomyosarcomas spread by extension into adjacent tissue planes. Direct extension into the heart is known, but not into the kidneys, adrenals, or bowel. IVC leiomyosarcomas arising below the renal vein cause pain in the right-lower quadrant, back, and flank, and varying degrees of lower extremity edema; those arising in the middle caval segment cause right-upper-quadrant pain and sometimes renovascular hypertension; those arising above the hepatic vein cause varying manifestations of the Budd-Chiari syndrome. A reasonable approach to early diagnosis involves oral and intravenous contrast studies followed by computed tomography, angiography, and vena cavography. Aggressive surgical treatment is optimal in light of the tumor's slow growth pattern and relatively low malignant potential. (Metastases have been reported in fewer than 50% of cases). Tumors involving the lower IVC are most amenable to surgery; extensive collateral venous drainage of the left kidney preserves renal function during resection of middle caval tumors. Upper caval leiomyosarcomas are the least amenable to complete removal. Postoperative survival of all patients has ranged from a few weeks to eight years.

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“…In our case the diagnosis was made too late, but if it had been made at an earlier stage, an operation (Cope and Hunt, 1954) could have been attempted.…”

Section: Discussionmentioning

confidence: 86%