Leiomyosarcoma of the head and neck: Report of two cases and review of the literature

Akçam, Timur; Oysul, Kaan; Bırkent, Hakan; Gerek, Mustafa; Yetışer, Sertaç

doi:10.1016/j.anl.2005.01.012

Cited by 43 publications

(45 citation statements)

References 17 publications

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“…The LMS is positive for musclespecific actin and vimentin and negative for S-100, myoglobulin, and epithelial membrane antigen on immunostaining. 4 At the first pathology report, owing to insufficient immunohistochemical investigation, the tumor was misdiagnosed as Bspindle-cell myoepithelioma[ instead of LMS in this particular case.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

A Rare Diagnosis in the Head and Neck Region

Haberal¹,

Alagöz²,

Öksüzoğlu³

et al. 2010

Journal of Craniofacial Surgery

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A rare case of leiomyosarcoma in the neck was presented. Several common characteristics of head and neck leiomyosarcoma were summarized in this case: the low-grade behavior of this tumor, the difficulty of aspiration cytology to provide accurate morphologic classification of this like most other soft tissue tumors, the necessity for appropriate immunohistochemical investigation for accurate diagnosis, the nonspecificity of the radiologic findings, the necessity for en bloc three-dimensional resection of the tumor with adequate soft tissue margins that is actually the mainstay of treatment in this type of cancer, and the propensity to metastasize to distant organs.

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Section: Discussionmentioning

confidence: 92%

“…Aberrant mesenchymal differentiation and metastasis are the other possible modes of origin. 4 Radiologic investigations are frequently nonspecific for diagnosis. Musculoskeletal lesions/large lesions in the head and neck are primarily evaluated with MRI because of its superior soft tissue contrast and better definition of tumor boundaries.…”

Section: Discussionmentioning

confidence: 99%

A Rare Diagnosis in the Head and Neck Region

Haberal¹,

Alagöz²,

Öksüzoğlu³

et al. 2010

Journal of Craniofacial Surgery

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“…[20][21][22] Currently, there are no standard criteria for therapy, although the complete excision of the tumour with wide surgical margins is recommended. 7,23,24 The five-year survival rate among patients with primary oral LMS is 55%, with bone involvement and metastasis significantly associated with poorer prognosis. 24 Lung and cervical lymph node metastases frequently occur, with the regional lymph nodes affected in >15% of oral LMS cases.…”

Section: Discussionmentioning

confidence: 99%

Gingival Leiomyosarcoma in a Young Woman: Case report and literature review

Viviano

Miracco

Lorenzini

et al. 2018

Sultan Qaboos Univ Med J

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Leiomyosarcoma (LMS) is a rare mesenchymal malignancy, of which 3-10% of cases occur in the head and neck region. We report a 22-year-old woman who was referred to the University Hospital of Siena, Italy, in 2016 with an ostensibly benign asymptomatic lump on the mandibular gingiva. The lesion grew rapidly, causing otalgia in the right ear. An excisional biopsy was performed and primary LMS was diagnosed histologically. Subsequently, the patient underwent radical re-excision of the perilesional mucosa, a partial bone resection and the extraction of four teeth. No recurrences or metastases were detectable at a 20-month follow-up. This report discusses the differential diagnosis of LMS with regards to other benign and malignant lesions and reviews the recent literature on primary and secondary oral LMS. Due to its innocuous clinical features-including its asymptomatic nature and presentation at a young age-this aggressive malignancy can go undetected; therefore, an early histopathological diagnosis is crucial.

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“…The lungs are the most frequent site of metastasis. The estimated 5-year survival is reported to be 55% [74]. Multivariate analysis of a cohort of 225 patients with leiomyosarcomas of all sites showed that higher malignancy grade, larger tumor size and deeper tumor location were correlated significantly with decreased metastasis-free and overall survival [75].…”

Section: Leiomyosarcomamentioning

confidence: 99%

Sarcomas of the head and neck in adult patients: current concepts and future perspectives

Rapidis

2008

Expert Review of Anticancer Therapy

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Sarcomas comprise a heterogeneous and biologically diverse group of malignant neoplasms having as a common denominator their origin from mesenchymal cells. Head and neck sarcomas account for 4 to less than 20% of total body sarcomas depending on the criteria, such as age of patients (pediatric vs adult population), type of sarcomas (soft-tissue vs bony sarcomas) and site of location. Although head and neck sarcomas occur infrequently in adults, in the pediatric population one in three sarcomas will occur in the head and neck region. Most head and neck sarcomas are of the soft-tissue type, with only 20% being of bony or cartilaginous origin. Sarcomas display a diverse array of histologies and a wide spectrum of clinical behavior, ranging from relatively slow growing lesions to aggressive locally and regionally destructive tumors with the potential for systemic metastases. Osteosarcomas, rhabdomyosarcomas, pleomorphic sarcomas (malignant fibrous histiocytomas), fibrosarcomas and angiosarcomas are among the most common histologic types of sarcoma found in the head and neck. Surgery has been the primary therapeutic approach for the management of head and neck sarcomas. Survival rates for head and neck sarcomas suggest worse outcomes than for their extremity counterparts. Lymph node metastasis only occurs in 3-10% of sarcomas of the head and neck. An improvement in local disease control has recently been suggested with the combined use of surgery and radiotherapy. Conflicting results have been reported on the benefit from the use of chemotherapy as an adjuvant or neoadjuvant regimen, especially for high-grade sarcomas in long-term survival or local disease control. Encouraging results have recently been reported with the use of molecular targeted therapies with tyrosine kinase inhibitors and antiangiogenetic agents.

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Leiomyosarcoma of the head and neck: Report of two cases and review of the literature

Cited by 43 publications

References 17 publications

A Rare Diagnosis in the Head and Neck Region

A Rare Diagnosis in the Head and Neck Region

Gingival Leiomyosarcoma in a Young Woman: Case report and literature review

Sarcomas of the head and neck in adult patients: current concepts and future perspectives

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