Leiomyosarcoma of the Larynx: A Complex Diagnosis

Molteni, Gabriele; Soloperto, Davide; Fabbris, Cristoforo; Gazzini, Luca; Rossi, Stefano De; Valotto, Giovanni; Marchioni, Daniele

doi:10.1177/0145561319840204

Cited by 2 publications

(9 citation statements)

References 8 publications

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“…LLMS is uncommon; we identified 62 cases in the English‐language literature (Table 1). 1,3–55 Tangjaturonrasme found that the number of LLMS cases was increasing; four cases were reported from 1961 to 1970, compared to 21 cases from 2000 to 2010. This may be a result of advances in diagnostic techniques, including immunohistochemical techniques and electron microscopy 46 .…”

Section: Discussion/literature Reviewmentioning

confidence: 99%

“…There were no significant differences between the distant metastasis and no distant metastasis (Fisher's exact test, p = 0.467). Nine patients (17.0%) had local recurrence (1–16 months after primary surgery) 1,4,5,23,30,46,52,58,59 . These patients underwent a second resection.…”

Section: Discussion/literature Reviewmentioning

confidence: 99%

“…It was first reported by Jackson and Jackson in 1939 2 . To the best of our knowledge, 62 cases of LLMS have been reported in the English‐language literature 1,3–55 …”

Section: Introductionmentioning

confidence: 99%

“…Factors predisposing to LLMS include radiation exposure, surgery, multiple basal cell carcinoma syndrome, Gardner syndrome, tuberous sclerosis, neurofibromatosis, Werner syndrome, retinoblastoma, Turcot syndrome, and Epstein–Barr virus (EBV) infection in immunosuppressed patients 1,3–55 …”

Section: Introductionmentioning

confidence: 99%

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Epstein–Barrvirus‐associated leiomyosarcoma of the larynx in an adult patient with human immunodeficiency virus infection: Case report and review of the literature

et al. 2022

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We investigated the clinical features, treatment, and prognosis of laryngeal leiomyosarcoma (LLMS) and Epstein-Barr virus-associated (EBV-associated) LMS. We report a case of EBV-associated LLMS in an adult patient with HIV infection. We also conducted a review of the English-language literature on LLMS and EBV-associated leiomyosarcoma. To the best of our knowledge, 62 cases of LLMS and EBV-associated leiomyosarcoma have been reported to date. Of patients with LLS, 18.9% had distant metastases and 17.0% had local recurrence. The overall 5-year survival rate was 64.0%. Distant metastases affected the survival of patients with LLMS (p = 0.04). EBV-positive patients had a low survival rate (p = 0.01). Among patients with EBV-associated LMS, 8.2% had distant metastases and recurrence and the overall 5-year survival rate was 50.0%. EBV-associated LLMS is rare. The EBV infection might be a poor prognostic factor of LLMS.

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Section: Discussion/literature Reviewmentioning

confidence: 99%

Section: Discussion/literature Reviewmentioning

confidence: 99%

“…It was first reported by Jackson and Jackson in 1939 2 . To the best of our knowledge, 62 cases of LLMS have been reported in the English‐language literature 1,3–55 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Epstein–Barrvirus‐associated leiomyosarcoma of the larynx in an adult patient with human immunodeficiency virus infection: Case report and review of the literature

et al. 2022

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“…There are some evidences regarding the adjuvant use of RT which slightly reduce the risk of local recurrences in patients with LLMS [14]. Conventional RT is proved to be ineffective as treatment of laryngeal chondrosarcoma due to slow-growing nature of tumor, although it has a role as adjuvant treatment or palliative measure.…”

Section: Discussionmentioning

confidence: 99%

Primary sarcomas of the larynx: A report of three cases and literature review

et al. 2022

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Introduction. Primary sarcomas are uncommonly seen in larynx and comprise around 1% of all laryngeal malignant tumors. We present three cases of patients with different types of laryngeal sarcomas and discuss about diagnostic and treatment difficulties. Case outline. Each patient presented with hoarseness and shortness of breath. Computed tomography scans showed large transglottic tumors of the larynx with no signs of cervical lymphadenopathy and definitive diagnoses of sarcomas were made by pathologists. Each patient underwent total laryngectomy with clear resection margins. Patient with laryngeal leiomyosarcoma developed large locoregional relapse of malignant disease and pulmonary metastasis four months after surgery and patient with laryngeal osteosarcoma was diagnosed with inoperative locoregional relapse of malignant disease three months after surgery. Both patients died within six months after surgery. On the other hand, patient with laryngeal chondrosarcoma was disease-free during three-year follow-up. Conclusion. Primary laryngeal sarcomas have low incidence and they differ from SCC by their biological characteristics and behavior. Radical surgical resection remains the mainstay of treatment with uncertain outcome due to their high potential for recurrence or metastatic spread.

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Leiomyosarcoma of the Larynx: A Complex Diagnosis

Cited by 2 publications

References 8 publications

Epstein–Barrvirus‐associated leiomyosarcoma of the larynx in an adult patient with human immunodeficiency virus infection: Case report and review of the literature

Epstein–Barrvirus‐associated leiomyosarcoma of the larynx in an adult patient with human immunodeficiency virus infection: Case report and review of the literature

Primary sarcomas of the larynx: A report of three cases and literature review

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