Leiomyosarcoma Of The Thyroid Gland: A Review Of The Literature And Our Experience

Mevio, E; Mevio, Niccolò; Cazzaniga, Marco; Sbrocca, M.; Migliorini, L; Mullace, Mauro

doi:10.14302/issn.2574-4496.jtc-13-347

Cited by 3 publications

(7 citation statements)

References 16 publications

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“…Primary leiomyosarcoma (LMS) of the thyroid gland is a very rare tumor which accounts for 0.014%. They usually develop in older people (mean age 66 years) with no gender predisposition [4,5]. Primary LMS may originate from smooth muscle cells of the capsule vessels.…”

Section: Discussionmentioning

confidence: 99%

“…The initial symptom of all adult cases in the literature was mainly a rapidly growing mass in the neck, which causes breathing obstruction and dysphagia [3]. Primary LMS has no characteristic imaging features that might be useful for diagnostic purposes [5]. However, in the tumors observed in the ultrasonography (US) had smooth borders or were irregularly hypoechoic without halo, had cystic parts, were solid, and in some cases were calcified masses [3].…”

Section: Discussionmentioning

confidence: 99%

“…Spindle cell tumor with thymus-like differentiation (SETTLE), anaplastic thyroid carcinoma and medullary thyroid carcinoma are thyroid epithelial tumors that can imitate sarcomas with a spindle cell pattern [5]. Thus, it can be difficult to exclude a diagnosis of undifferentiated thyroid carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Case report: a grievous tale of a rare primary thyroid leiomyosarcoma

Mansor

Gani

Dahari

et al. 2023

Egypt J Otolaryngol

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Background Primary thyroid leiomysosarcoma is a rare and aggressive disease which represents 0.014% of primary thyroid cancers. It confers a diagnostic conundrum, due to difficulty to make a preoperative diagnosis of thyroid leiomyosarcoma and to differentiate it from anaplastic thyroid carcinoma. Case presentation We herein report a rare case of primary thyroid leiomyosarcoma. A 48-year-old male presented with history of anterior neck swelling for the past 2 months. Computed tomography (CT) neck showed hypodense nodule at the right thyroid lobe with calcification causing tracheal deviation, with intratracheal extension at 1st and 2nd tracheal rings and presence of lung metastases. The histopathology analysis yield high grade spindle cell neoplasm suggestive of sarcoma. Immunohistochemistry showed that neoplastic spindle cells were positive for smooth muscle actin, vimentin, caldesmon while no reactivity was reported for thyroglobulin, calcitonin, thyroid transcription factor-1, S-100, CD45, CD 5, and cytokeratins. Patient had undergone tracheostomy and chemotherapy but he succumbed to death 1 month after completion of chemotherapy. Conclusion Primary thyroid leiomyoarcoma is a very rare and aggressive disease. The treatment ranging from surgery, adjuvant radiotherapy and chemotherapy, with high recurrence rates.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Case report: a grievous tale of a rare primary thyroid leiomyosarcoma

Mansor

Gani

Dahari

et al. 2023

Egypt J Otolaryngol

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“…8 shown a positive effect on the high recurrence rate and poor survival of these tumours. 16 A recent review of published cases indicated that 14 out of 23 patients died within months; four of the seven who survived had a recurrent and/or metastatic disease. Among these, the longest duration of the patient to be disease-free was 5 years.…”

Section: Discussionmentioning

confidence: 99%

“…Primary LMS of the thyroid is a rare tumour and approximately only 30 cases have been reported previously. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] The other common sites for LMS are gastrointestinal tract, retroperitoneum and pelvis. 23 According to the histological tumour classification by World Health Organization (WHO), thyroid LMS is classified as a member of the smooth-muscle tumours of thyroid gland.…”

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confidence: 99%

Primary Leiomyosarcoma of the Thyroid Gland – A Rare Malignancy

Reddy¹,

Aggarwal²,

Ak³

et al. 2019

European Endocrinology

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Primary leiomyosarcoma of the thyroid gland

Kaur

Chatterjee

Aggarwal

et al. 2022

Indian Journal of Pathology and Microbiology

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Sarcoma is a rare tumor of the thyroid gland, primary thyroid leiomyosarcoma (LMS) being even rarer. We present a case of LMS of the thyroid in a middle-aged female. Histopathologic examination in conjunction with immunohistochemistry helped to clinch the diagnosis. Knowledge of this entity is important to distinguish it from anaplastic thyroid carcinoma (ATC) and other sarcomas arising in the thyroid and adjacent soft tissue. The prognosis of thyroid LMS is dismal with an extremely poor survival rate.

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Leiomyosarcoma Of The Thyroid Gland: A Review Of The Literature And Our Experience

Cited by 3 publications

References 16 publications

Case report: a grievous tale of a rare primary thyroid leiomyosarcoma

Case report: a grievous tale of a rare primary thyroid leiomyosarcoma

Primary Leiomyosarcoma of the Thyroid Gland – A Rare Malignancy

Primary leiomyosarcoma of the thyroid gland

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