Leiomyosarcomas in children: clinical and pathologic characteristics

Angel, Carlos; Gant, Linda L.; Parham, David M.; Rao, Bhaskar N.; Douglass, Edwin C.; Lobe, Thom E.

doi:10.1007/bf00183916

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…Apart from the uterus, soft tissue leiomyosarcoma commonly occurs in the retroperitoneum and blood vessels. Leiomyosarcomas of non-peritoneal soft tissue sites usually involves the lower extremity and can also occur in the head and neck region [6]. They are most commonly found in the uterus, stomach, small intestine, and retroperitoneum [7].…”

Section: Discussionmentioning

confidence: 99%

Primary renal leiomyosarcoma: A rare case report

Nandi¹,

Das²,

Das³

et al. 2021

Indian J Case Reports

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Leiomyosarcoma of the kidney is a rare type of adult renal sarcoma. Here, we presented a case of a 68-year-old female who had a past history of bilateral renal calculi 3 years back with hydronephrotic changes, now presented to the OPD with complaints of abdominal pain for the past few months. On further evaluation, a heterogeneously enhancing necrotic mass was identified in the right kidney measuring 7.5 cm in the greatest dimension. A right radical nephrectomy with left Double J stenting was done. From histopathological and immunohistochemical staining, it was diagnosed as leiomyosarcoma.

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Section: Discussionmentioning

confidence: 99%

Primary renal leiomyosarcoma: A rare case report

Nandi¹,

Das²,

Das³

et al. 2021

Indian J Case Reports

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“…Apart from the uterus, soft tissue leiomyosarcoma commonly occurs in the retroperitoneum, and also arises from the blood vessels. Leiomyosarcomas of nonperitoneal soft tissue sites usually involve the lower extremity but they can occur in the head and neck region also [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Leiomyosarcoma of the Kidney

Saini

Niveditha

Krishnagiri

et al. 2010

Pathology Research International

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Primary leiomyosarcoma of the kidney is a rare tumor with an aggressive behaviour. A 55-year-old woman presented with a left sided abdominal mass in our outpatient department. Radiologic investigations revealed the mass to be renal in origin with colonic adhesions for which radical nephrectomy and hemicolectomy were done. The tumor completely appeared to replace the left kidney and had a whorled character focally on cut section. Microscopically, spindle cells having malignant features with cigar shaped nuclei were seen. The smooth muscle origin of the cells was confirmed by immunohistochemical positivity for smooth muscle actin. Sarcomatoid variant of the renal cell carcinoma was ruled out as the tumor was negative for cytokeratin. Tumors with spindle cell morphology in the kidney should not always be taken for a sarcomatoid variant of renal cell carcinoma and should be investigated thoroughly.

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“…LMS in non-immunocompromised children less than 5 years of age are quite rare. A literature review showed approximately 20 cases with no example of epithelioid LMS (3,5,12,(16)(17)(18). Also, epithelioid LMS has never been reported in an immunocompromised child.…”

Section: Discussionmentioning

confidence: 99%

“…The first treatment of choice is complete surgical excision that correlates best with a favorable outcome (3). Epithelioid LMS should be added in the list of differential diagnoses of pediatric "round cell tumors" to avoid possible misdiagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Epithelioid Leiomyosarcoma in a Non-Immunocompromised Infant: Additional Differential Diagnosis of Pediatric “Round Cell Tumors”

et al. 2000

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We report an 18-month-old Japanese girl with purely epithelioid leiomyosarcoma presenting as a huge intraabdominal mass. The patient had been well from birth and had shown no signs of immunodeficiency. She was negative for human immunodeficiency virus. Blood examination revealed elevated serum neuron specific enolase (NSE). Histologically, the tumor was comprised of solid growths of round or polygonal cells with vesicular nuclei and often vacuolated cytoplasm rich in glycogen. The tumor cells were positive for vimentin, NSE, and MIC2, and were negative for desmin and neurofilament. The age, clinical presentation, and histologic findings mostly favored Ewing's sarcoma/ primitive neuroectodermal tumor. Silver stain, however, demonstrated well-developed reticulin fibers often outlining individual tumor cells. An expanded panel of immunostains showed that the tumor cells were intensely positive for smooth muscle actin, and ultrastructural study revealed abundant fine cytoplasmic filaments with focal subsarcolemmal densities, various amounts of glycogen, and irregularly arranged, thick basal lamina. The diagnosis of epithelioid leiomyosarcoma was made. Following reduction in tumor size by chemotherapy, the serum NSE level was normalized. From the surgical finding, the primary site was presumed to be the urachus or the urinary bladder dome. Although extremely rare, epithelioid leiomyosarcoma should be added in the list of differential diagnoses of pediatric "round cell tumors."

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Leiomyosarcomas in children: clinical and pathologic characteristics

Cited by 6 publications

References 25 publications

Primary renal leiomyosarcoma: A rare case report

Primary renal leiomyosarcoma: A rare case report

Primary Leiomyosarcoma of the Kidney

Epithelioid Leiomyosarcoma in a Non-Immunocompromised Infant: Additional Differential Diagnosis of Pediatric “Round Cell Tumors”

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