Leishmania and Leishmaniasis

Kumar, Awanish

doi:10.1007/978-1-4614-8869-9

Cited by 25 publications

(56 citation statements)

References 138 publications

(202 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7). 124,125 These drugs are used for the treatment of either cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL) or visceral leishmaniasis (VL). 121 Antimonials were the first antileishmania compounds, introduced in the 40s decade.…”

Section: Standard Drugsmentioning

confidence: 99%

Leishmania Proteomics: An in Silico Perspective

Padilla¹,

Álvarez²,

Combariza³

2020

Preprint

View full text Add to dashboard Cite

We report on the state of the art of scientific literature about proteins recognized as potential targets for the development of Leishmania treatments through the search of biologically active chemical species, either from experimental in vitro, in vivo, or in silico sources. We classify the gathered information, in several ways: vector taxonomy and geographical distribution, parasite taxonomic and geographical distribution and enzymatic function (oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases and cytokines). Our aim is to provide a much needed reference layout for research efforts aimed to understand the underpinning physical interactions in ligand-protein activation/inactivation processes. In the specific case of Leishmania, we focus on enzymes known to be part of the biochemical molecular processes initiated following a Leishmania infectious episode.

show abstract

Section: Standard Drugsmentioning

confidence: 99%

Leishmania Proteomics: An in Silico Perspective

Padilla¹,

Álvarez²,

Combariza³

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In south America, again several species of Leishmania cause cutaneous form of the disease [11,15] (Table 1). Table 1 The main species of leishmania that cause human disease [11,15,16]. Leishmania species have a heteroxenous life cycle.…”

Section: The Parasitementioning

confidence: 99%

“…There are over 600 species of sand flies divided into five genera: Phlebotomus and Sergentomyia in the Old World and Lutzomyia, Brumptomyia, and Warileya in the New World [4,16,17]. Although human-biting sandflies occur in various genera, the only proven vectors of human leishmaniasis are species and subspecies of the genus Phlebotomus and Lutzomyia (Table 2).…”

Section: The Vectormentioning

confidence: 99%

Leishmaniasis: A Review on Parasite, Vector and Reservoir Host

Alemayehu¹,

Alemayehu²

2017

Health Sci J

129

View full text Add to dashboard Cite

Leishmaniasis is a vector-borne disease affecting millions of people worldwide. The disease is caused by different species of Leishmania, and it is manifested by three major clinical forms namely cutaneous, muco-cutaneous and visceral leishmaniasis. This review is aimed to address briefly the parasite, the vector and the reservoir aspects in transmission of leishmaniasis in different regions of the world. The complexity of transmission of the disease lays on the complex life cycle of the parasite which involves sand fly vectors and mammalian reservoirs. The transmission can either be zoonotic and/or anthroponotic through the bite of an infected female sand fly. There is uneven global distribution of the disease often because of the various distribution patterns of the parasite, the vector and the reservoir host species. Various sand fly species in the genus Phlebotomus and Lutzomyia are responsible for transmission of leishmaniasis in the old and new worlds. Animal reservoirs are important for maintaining infections in various areas, and hence are important for zoonotic and rural/sylvatic transmission of the disease. A high prevalence of infection has been reported from small to large domestic and wild mammals. Control and elimination of leishmaniasis require detection of human and animal cases, identification of reservoir hosts, and implementation of effective vector control strategies in areas.

show abstract

“…A infecção promove uma série de sintomas caracterizados por febre prolongada, aumento do volume de alguns órgãos, como baço e fígado, perda de peso, diminuição dos componentes sanguíneos e consequente anemia. A forma clínica clássica leva à morte do indivíduo, devido ao enfraquecimento do sistema imunológico do paciente causado pela severa infecção do parasito [44]. O tratamento da parasitose é dependente tanto do sistema hospedeiro quanto do protozoário, com alguns tratamentos sendo eficientes somente para determinadas espécies de leishmania e de algumas regiões geográficas.…”

Section: Cisteíno Proteases Como Alvo Terapêuticounclassified

“…Com o processo de replicação celular contínuo, a célula hospedeira sofre a lise devido à alta densidade parasitária no seu interior, liberando os parasitos que invadem outras células do sistema imune. Ao final, os protozoários invadem preferencialmente os tecidos que contêm grande quantidade de macrófagos, como baço, fígado e medula óssea[44].…”

unclassified

Planejamento molecular, atividade tripanossomicida e anticancerígena de inibidores covalentes reversíveis de cisteíno proteases

Junior¹,

Carlos²

View full text Add to dashboard Cite

Cysteine proteases (CP) activity has been related to different pathologies, such as leishmaniasis, Chagas disease and some types of cancer. Due to the homology between cysteine proteases expressed by these cellular systems, it was investigated here the importance of these enzymes for the development and establishment of these diseases based on the in vitro biological activity of novel reversible cysteine protease inhibitors. In general, inhibitors had a significant inhibitory activity of cysteine proteases in all assays, with a maximum inhibition of 42 % for Neq0554 concerning the CP activity expressed by Leishmania spp. and 76 % to CP activity expressed by pancreatic cancer cells. Different profiles of biological activity were observed between the cellular systems, but all substances had significant CP activity suppression, in cytostatic levels after the inhibition of CPA. When the inhibitors were tested against Leishmania spp., the cell growth was suppressed by at least 67 %, with maximum inhibition of 95% for Neq0551 at 10 μM. Similarly in pancreatic cancer cells, changes in the cell cycle profile were the most evident results, as well as the suppression of migration and colony formation ability, with 50 % retention of the colony development of MiaPaCa-2 cells by Neq0554 at 10 μM. In contrast, to protozoa from Trypanosoma cruzi Y strain, the inhibitors tested showed an interesting selectivity against the parasites concerning the host cell LLC-MK2, also promoting the in vitro cell invasion suppression in about 80% when the host cell was pre-treated with Neq0662 10 μM for 2 h. Finally, the encapsulation of Neq0554 promoted an increase in its anticancer activity against pancreatic cancer cells, with IC 50 of 79 μM alongside > 200 μM to fibroblast cells, besides increasing its selectivity. In general, the results corroborate the hypothesis that the inhibition of cysteine proteases in the cellular systems is efficient to promote cytostatic effects, being an interesting tool to be used as control and development suppression of some pathologies. Also, CP activity in protozoa cells and pancreatic cancer showed a similar profile of action, in which cysteine protease inhibitors did not promote death at a significant level for the cells, but emphasized cytostatic effects about cell growth.

show abstract

Leishmania and Leishmaniasis

Cited by 25 publications

References 138 publications

<em>Leishmania</em> Proteomics: An <em>in Silico</em> Perspective

<em>Leishmania</em> Proteomics: An <em>in Silico</em> Perspective

Leishmaniasis: A Review on Parasite, Vector and Reservoir Host

Planejamento molecular, atividade tripanossomicida e anticancerígena de inibidores covalentes reversíveis de cisteíno proteases

Contact Info

Product

Resources

About