Leishmania infantum strains from cats are similar in biological properties to canine and human strains

Pereira, André; Parreira, Ricardo; Cristóvão, José Manuel; Vitale, Fabrizio; Bastien, Patrick; Campino, Lenea; Maia, Carla

doi:10.1016/j.vetpar.2021.109531

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…This disease has so far been predominantly detected in children, but since the 1990s most cases are reported in HIV-infected adults [2]. Domesticated dogs (Canis lupus familiaris) are recognized as the main host and reservoir [3,4], but a recent increase in reported infections in cats (Felis catus) is questioning the role of this species in Leishmania's zoonotic cycle in urban and peri-urban habitats [5][6][7][8]. The phlebotomine species associated with Leishmania transmission in Portugal are Phlebotomus perniciosus and P. ariasi [9].…”

Section: Introductionmentioning

confidence: 99%

Molecular Identification and Ecology of Portuguese Wild-Caught Phlebotomine Sandfly Specimens

et al. 2022

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Phlebotomine sandflies are important vectors of Leishmania spp. and phleboviruses causing disease in animals and humans. Morphological identification of phlebotomine sandflies to the species level is challenging, requiring microscopical examination of the genitalia, which is demanding and time consuming. Molecular sandfly species identification can be a practical solution to save resources since it enables further molecular studies capable of generating data, such as biting preferences by blood meal analysis. In this study, resorting to a sandfly dataset collected between 2014 and 2018 across Portuguese territory under active mosquito surveillance and sandfly specific surveys, we used molecular methods to explore the genetic diversity and spatial distribution, further exploring ecological co-variants of four sandfly species—Phlebotomus ariasi, P. perniciosus, P. sergenti, and Sergentomyia minuta—all of which are of public health importance. Sandflies were collected from Spring to Autumn (May–November) following local temperature patterns. P. perniciosus was the most widespread detected species, with a nationwide distribution. All studied species clustered together with known samples from the Iberian Peninsula. Further monitoring studies of sandfly species diversity, distribution, and seasonality are essential for surveillance and control of sandfly-borne pathogens both nationally and globally.

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Section: Introductionmentioning

confidence: 99%

Molecular Identification and Ecology of Portuguese Wild-Caught Phlebotomine Sandfly Specimens

et al. 2022

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The Parasitemia has Contributed to the Severity of Cases of Visceral Leishmaniasis

Campelo,

Medvedovsky,

de Holanda

et al. 2024

Indian J Microbiol

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Review and statistical analysis of clinical management of feline leishmaniosis caused by Leishmania infantum

et al. 2022

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Background There is limited information about feline leishmaniosis (FeL) management in clinical practice. Leishmania infantum is the species of Leishmania most frequently reported in both dogs and cats in countries of the Mediterranean region (henceforth ‘Mediterranean countries’), Central and South America, and Iran. This study was conducted to provide veterinary clinicians with an updated overview of evidence-based information on leishmaniosis in cats. Methods A review was performed using PubMed, Science Direct, Google Scholar and Web of Science. Case reports of FeL caused by L. infantum were sought for the period 1912 to 1 June 2021. Results Sixty-three case reports are included in this review. Fifty-nine out of the 63 cats were from Europe, mostly from Mediterranean countries (88.9%). Most of them were domestic short-haired cats (90%) with a mean age of 7.9 years, and had access to the outdoors (77.3%). Sixty-six percent of the cats had comorbidities, of which feline immunodeficiency virus infection was the most frequent (37.7%). Dermatological lesions (69.8%) was the most frequent clinical sign, and hyperproteinemia (46.3%) the most frequent clinicopathological abnormality. Serology was the most performed diagnostic method (76.2%) and was positive for 93.7% of cats. Medical treatment was applied in 71.4% of cats, and allopurinol was the most used drug (74.4%). Survival time was greater for treated cats (520 days; 71.4% of cats) than non-treated cats (210 days; 25.4%). Conclusions The majority of the cats had comorbidities, of which feline immunodeficiency virus was the most frequent. Dermatological lesions were frequently reported, and systemic clinical signs and clinicopathological abnormalities were also common. Serology may be useful for the diagnosis of FeL in clinical practice, and a positive titer of ≥ 1/40 may be a useful cut-off for sick cats. The reported treatments and dosages varied, but there was a good clinical response and longer survival in most of the cats treated with allopurinol monotherapy. Graphical abstract

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Leishmania infantum strains from cats are similar in biological properties to canine and human strains

Cited by 4 publications

References 40 publications

Molecular Identification and Ecology of Portuguese Wild-Caught Phlebotomine Sandfly Specimens

Molecular Identification and Ecology of Portuguese Wild-Caught Phlebotomine Sandfly Specimens

The Parasitemia has Contributed to the Severity of Cases of Visceral Leishmaniasis

Review and statistical analysis of clinical management of feline leishmaniosis caused by Leishmania infantum

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