2020
DOI: 10.1016/j.molimm.2020.08.006
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Leishmania infantum transfected with toxic plasmid induces protection in mice infected with wild type L. infantum or L. amazonensis

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Cited by 5 publications
(3 citation statements)
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“…There is also evidence of the protective capacity of subunit vaccines based on antigens of parasite species that cause VL, such as vaccines formulated with ribosomal proteins from L. infantum (LRP) [16], some domains of the L. donovani nucleoside hydrolase (NH) [44], or a recombinant multiantigenic-composed DNA vaccine (HisAK70) generated by different DNA regions encoding several proteins from L. infantum [18]. Finally, it was reported recently that inoculation of L. infantum parasites programmed for their destruction in the host (because of the expression of genes encoding proteins toxic for the parasite) protects BALB/c mice against a L. amazonesis challenge [22].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…There is also evidence of the protective capacity of subunit vaccines based on antigens of parasite species that cause VL, such as vaccines formulated with ribosomal proteins from L. infantum (LRP) [16], some domains of the L. donovani nucleoside hydrolase (NH) [44], or a recombinant multiantigenic-composed DNA vaccine (HisAK70) generated by different DNA regions encoding several proteins from L. infantum [18]. Finally, it was reported recently that inoculation of L. infantum parasites programmed for their destruction in the host (because of the expression of genes encoding proteins toxic for the parasite) protects BALB/c mice against a L. amazonesis challenge [22].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, BALB/c mice were injected with L. infantum promastigotes bearing genes encoding for toxic proteins able to kill the amastigote forms in the vertebrate host. They presented a less severe disease when challenged with L. amanonensis, namely a reduction in skin lesions and parasite load compared to the animals of a control group [22]. Regarding the use attenuated lines generated by genetic modification, it has been shown that BALB/c mice vaccinated with a dihydrofolate-reductase thymidylate synthase L. major null mutant (Lmdhfr-ts -) were partially protected against a L. amazonensis infective challenge administered in the short term [23].…”
Section: Introductionmentioning
confidence: 99%
“…In Leishmania , there have been several studies using mCherry to monitor the course of infection as this reporter is suitable for intravital imaging and enables deeper tissue penetration than GFP ( Calvo-Álvarez et al., 2012 ; Corman et al., 2019 ). mCherry was also used to evaluate the amastin expression in L. infantum in a stage-specific manner ( Zorgi et al., 2020 ). Besides, mCherry is one of the possible tag options which can be used in the T7 RNA polymerase-dependent CRISPR-Cas9 toolkit system ( Beneke et al., 2017 ), and the glmS ribozyme-based knock-down system of L. tarentolae ( Turra et al., 2021 ).…”
Section: Enzymatic Systemsmentioning
confidence: 99%