Leishmania mexicana cell death achieved by Cleoserrata serrata (Jacq.) Iltis: Learning from Maya healers

Alamilla-Fonseca, Lorena; Delgado-Domínguez, José; Zamora‐Chimal, Jaime; Cervantes-Sarabia, Rocely; Jiménez-Arellanes, María Adelina; Rivero-Cruz, J. Fausto; Becker, Ingeborg

doi:10.1016/j.jep.2017.09.037

Cited by 10 publications

(9 citation statements)

References 14 publications

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“…The extract showed activity against the L. mexicana amastigotes at the concentration of 10 μg/mL; and against L. mexicana promastigotes, the effect was dose-dependent; in this case, the author observed 60% of inhibition at 100 μg/mL and 85% of inhibition at 200 μg/mL. The LD 50 doses were 23.5 μg/mL for promastigotes, and 6.11 μg/mL for the amastigotes [59]. This extract at 10 μg/mL showed leishmanicidal activity on amastigotes after 4 days of culture and at 100 μg/mL was leishmanicidal on promastigotes.…”

Section: Leishmaniases As Re-emerging Diseases 168mentioning

confidence: 92%

“…It is important to mention that the author did not describe the concentration of the extracts that they evaluated or their LD 50 values [57]. Alamilla-Fonseca et al [59] evaluated Cleoserrata serrata dichloromethane: methanol (1:1) extract. This Mexican medicinal plant is used in South-Central Mexico to treat skin infections and wounds.…”

Section: Leishmaniases As Re-emerging Diseases 168mentioning

confidence: 99%

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Natural Compounds and Extracts from Mexican Medicinal Plants with Anti-Leishmanial Activity: An Update

Jiménez-Arellanes¹,

León-Díaz²

2018

Leishmaniases as Re-Emerging Diseases

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Leishmaniasis is considered an emerging, uncontrolled disease, and is endemic in 98 countries. Annually, about 2 million cases of cutaneous and 500,000 cases of visceral type leishmaniasis are recorded, and 60,000 persons die from the disease. In Mexico, cutaneous leishmaniasis is known as chiclero's ulcer and is reported in 22 states; it is considered a health problem. For its treatment, pentavalent antimonial drugs are administered; these drugs cause severe side effects, are costly, and drug-resistant cases have been reported and have been developing for >70 years. One alternative to the drugs that are currently available is to find active molecules in medicinal plants; dihydrocorynantheine, corynantheine, and corynantheidine are active against Leishmania major, while harmane, pleiocarpin, buchtienin, luteolin, and quercetin are active against L. donovani. In Mexico, about 20 medicinal plants have been evaluated against L. mexicana, among which the most active are Tridax procumbens, Tridax procumbens, Pentalinon andrieuxii, Lantana camara, Schinus molle, and Prosopis laevigata. From some of these plants, active compounds with IC 50 ≤ 30 μg/mL or μM have been isolated, such as 3(S)-16,17-didehydrofalcarinol or Oxylipin, cholestra-4,20,24-trien-3-one or pentalinosterol, 24-methylcholest-4-24(28)-dien-3-one, cholest-4-en-3-one, 6,7-dihy-droneridie-none, neridienone, cholest-5,20,24-trien-3β-ol, and isocordoin. Today, the only pentalinonsterol has been synthesized and assayed in the visceral leishmaniasis experimental model using BALB/c mice infected with L. donovani. Liposome formulation of this compound administered by intravenous route at 2.5 mg/kg showed a significant reduction of parasite load in mouse liver and spleen.

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Section: Leishmaniases As Re-emerging Diseases 168mentioning

confidence: 92%

Section: Leishmaniases As Re-emerging Diseases 168mentioning

confidence: 99%

Natural Compounds and Extracts from Mexican Medicinal Plants with Anti-Leishmanial Activity: An Update

Jiménez-Arellanes¹,

León-Díaz²

2018

Leishmaniases as Re-Emerging Diseases

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“…6 In La Chontalpa and Cunduacan, Tabasco, the leaves are used as infusion or cataplasm to treat the skin lesion in patients with cutaneous leishmaniasis (caused by Leishmania spp) known as "chicleros ulcer". 7 It is also employed in southern and central regions in Mexico for skin infections. 8 In addition, Amerindian groups (Kuna, Ngöbe-Buglé and Teribe) from Panama employ the whole plant in topical warm baths and the leaves for the treatment of snake bites.…”

Section: Introductionmentioning

confidence: 99%

“…8 In addition, Amerindian groups (Kuna, Ngöbe-Buglé and Teribe) from Panama employ the whole plant in topical warm baths and the leaves for the treatment of snake bites. 9 Recently, Alamilla-Fonseca et al 7 described leishmanicidal and antibacterial activities for the dichloromethane:methanol (CH 2 Cl 2 :MeOH, 1:1) extract from C. serrata leaves. This extract showed mean lethal doses (LD 50 ) = 6.11 and 23.5 µg/mL against Leishmania mexicana (L. mexicana) amastigotes and promastigotes, respectively; this effect was dose-dependent.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Anti-Inflammatory Potential of the Organic Extracts from Cleoserrata serrata (Jacq.) Iltis.

Juárez-Vázquez¹,

A²,

León-Díaz³

et al. 2021

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Cleoserrata serrata is used in Mexican-south traditional medicine to treat chicleros ulcer. The phytochemical profile and the anti-inflammatory effect from four extracts obtained by maceration proccess and of the primary fractions from two extracts are described. In addition, the antioxidant, leishmanicidal and antimycobaterial activities and LD 50 from active extracts are reported. Anti-inflammatory activity was evaluated in TPA and carrageenan assays. Ethyl palmitate and γ-sitosterol were detected in Hexanic and CH 2 Cl 2 extracts. Same compounds and stigmasta-3,5-dien-7-one, palmitic acid, phytol acetate and phytol were detected in primary fractions from CH 2 Cl 2 :EtOH extract. In this and in MeOH extracts a polyphenolmixture was obtained. The MeOH extract was subjected to acid hydrolysis, and kaempferol, quercetin and scopoletin were detected in organic-phase. Polyphenol-mixture and organic-phase (IC 50 =3730 and 2338 μg/mL) showed moderate antioxidant activity; meanwhile MeOH extract exhibited scarce activity. In carrageenan model, Hexanic extract and polyphenol-mixture showed ED 50 =131.46 and 64.89 mg/ kg, respectively. Three extracts were active but not-dose-dependent. In TPA-model, CH 2 Cl 2 extract and polyphenol-mixture showed ED 50 <0.79 mg/ear, and three extracts were active, however the effect was not-dose-dependent. CH 2 Cl 2 :EtOH showed antimycobacterial and leishmanicidal activities. The LD 50 was >2 g/kg for all extracts.

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“…In particular, species from the Cleomaceae family have been evaluated for the presence of bioactive compounds owing to their use in traditional medicine (Sivanesan & Begum 2007;Abdullah et al 2016;Alamilla-Fonseca et al 2018). The Cleomaceae family comprises 18 genera and about 350 species, mostly annual, but sometimes perennial herbaceous plants and shrubs widely distributed in tropical and subtropical regions (Patchell et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Micropropagation of Tarenaya rosea (Cleomaceae) from leaf explants

et al. 2021

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In vitro culture techniques are recognized as efficient strategies for large-scale plant production, as well as providing alternatives for plant conservation. In this study the micropropagation of Tarenaya rosea was established using petiole and foliar blade segments cultivated on MS medium with 6-benzyladenine (BA) and/or 6-furfurylaminopurine (KIN). The regeneration rate from explants was evaluated after 30-days in culture, as well as the proliferation rate from explant-derived shoots, reached after four subcultures performed at 30-days in culture. In vitro propagation occurred by both direct (DO) and indirect (IO) organogenesis. The highest regeneration rates by DO (50% to 100%) were reached on media containing only BA, while morphogenic calluses (IO) were mainly formed with BA+KIN. Explants on media with BA showed the presence of small black nodules on their surface, and histological analysis revealed the presence of trichomes with anthocyanin content. Elongation and rooting were reached on growth regulator-free MS. Acclimatization rates around 80% were achieved and the in vitro-regenerated plants were successfully maintained under field conditions. Results show significant morphogenetic potential of T. rosea from leaf explants, mainly when cultivated in the presence of 4.4 µM BA, providing a new alternative source of plant material for biotechnological and in vitro conservation studies.

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Leishmania mexicana cell death achieved by Cleoserrata serrata (Jacq.) Iltis: Learning from Maya healers

Cited by 10 publications

References 14 publications

Natural Compounds and Extracts from Mexican Medicinal Plants with Anti-Leishmanial Activity: An Update

Natural Compounds and Extracts from Mexican Medicinal Plants with Anti-Leishmanial Activity: An Update

Phytochemical Screening and Anti-Inflammatory Potential of the Organic Extracts from Cleoserrata serrata (Jacq.) Iltis.

Micropropagation of Tarenaya rosea (Cleomaceae) from leaf explants

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