Leishmania, the phagosome, and host responses: The journey of a parasite

Séguin, Olivier; Descoteaux, Albert

doi:10.1016/j.cellimm.2016.08.004

Cited by 36 publications

(31 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Kum sineğinin memeli konağı soktuğu bölgeye ilk ulaşan hücreler nötrofillerdir (24,25). Nötrofiller Leishmania promastigotlarını fagosite ederler ancak parazit nötrofil içerisinde yaşamda kalmayı başarır ve hatta çoğalabilir (26).…”

Section: Nötrofil Lökositlerin İçinde Gizlenme Stratejisiunclassified

“…Bu nedenle bu fagositik hücrelerin bölgeye hızlı bir şekilde göç etmesi Leishmania için önemlidir. Yapılan araştırmalar kum sineği tükürüğünün memeli konaktaki fagositik hücre göçünü üç kat arttırdığını ve Leishmania'nın salgıladığı PSG ile birlikte nötrofil ve makrofaj gibi hücrelerin bölgeye toplanmasına, dolayısıyla Leishmania için başarılı bir enfeksiyonun gerçekleşmesine katkıda bulunduğunu göstermektedir (14,25). Nötrofiller hücre dışı matriks içerisine DNA iskeleti üzerine bağlanmış mikrop öldürücü proteinlerin yer aldığı "nötrofil hücre dışı tuzakları" (NETs = Neutrophile Extracellular Traps) salgılayarak patojeleri yakalar, yayılmalarını önler ve bazı durumlarda öldürürler (26).…”

Section: Nötrofil Lökositlerin İçinde Gizlenme Stratejisiunclassified

See 1 more Smart Citation

Survival Strategies of <i>Leishmania</i> in Hosts

Demir

2019

Turkiye Parazitol Derg

View full text Add to dashboard Cite

In all major parasite groups, new and surprising evidence is emerging every day about the subtlety, complexity and diversity of avoidance mechanisms from host immune system. In the course of millions of years of evolutionary process, mammalian and sand fly hosts have developed defense systems against Leishmania, but Leishmania has not only escaped from their hosts' defense systems through complex counter-strategies, but has also managed to manipulate them to support their own survival and reproduction. In this study, Leishmania's survival strategies used in the sand fly and mammalian hosts and the mechanisms that underlie these strategies will be summarized.Tüm büyük parazit gruplarında, konak bağışıklık sisteminden kaçınma mekanizmalarının inceliği, karmaşıklığı ve çeşitliliği konusunda her geçen gün yeni ve şaşırtıcı kanıtlar ortaya çıkmaktadır. Milyonlarca yıllık evrimsel süreçte memeli ve kum sineği konaklar Leishmania'ya karşı savunma sistemleri geliştirmiş buna karşın Leishmania da karmaşık karşı stratejiler sayesinde konaklarının savunma sistemlerinden kaçmakla kalmamış onları kendi yaşamını ve üremesini destekleyecek şekilde manipüle etmeyi de başarmıştır. Bu çalışmada Leishmania'nın kum sineği ve memeli konaklarında kullandığı hayatta kalma stratejileri ve son araştırmalar ışığında bu stratejilerin altında yatan mekanizmalar özetlenecektir.Anahtar Kelimeler: Leishmania, kum sineği, sağkalım stratejileri, lipofosfoglikan Demir S. Leishmania'nın Konak İçerisindeki Sağkalım Stratejileri. Turkiye Parazitol Derg 2019;43(2):83-8.

show abstract

Section: Nötrofil Lökositlerin İçinde Gizlenme Stratejisiunclassified

Survival Strategies of <i>Leishmania</i> in Hosts

Demir

2019

Turkiye Parazitol Derg

View full text Add to dashboard Cite

show abstract

“…comprises several species and causes leishmaniasis, which affects more than 300 million people worldwide (2). This parasite has a complex life cycle composed of two distinct stages: the promastigote form found in the female sandfly vector and the amastigote form replicated in the mammalian host (3). Trypanosoma brucei causes the fatal illness human African trypanosomiasis (4), which is adapted to parasitize the mammalian bloodstream after inoculation by the tsetse fly ( Glossina spp.).…”

Section: Introductionmentioning

confidence: 99%

The Roles of Mast Cells in Parasitic Protozoan Infections

Huang

2017

Front. Immunol.

View full text Add to dashboard Cite

Protozoan parasites such as Plasmodium spp., Leishmania spp., Trypanosoma spp., and Toxoplasma gondii are major causes of parasitic diseases in both humans and animals. The immune system plays a critical role against protozoa, but their immune mechanism remains poorly understood. This highlights the need to investigate the function of immune cells involved in the process of parasite infections and the responses of host immune system to parasite infections. Mast cells (MCs) are known to be central players in allergy and anaphylaxis, and it has been demonstrated that MCs have crucial roles in host defense against a number of different pathogens, including parasites. To date, there are many studies that have examined the interaction of helminth-derived antigens and MCs. As one of the major effector cells, MCs also play an important role in the immune response against some parasitic protozoa, but their role in protozoan infections is, however, less well characterized. Herein, we review the current knowledge about the roles of MCs and their mediators during infections involving highly pathogenic protozoa including Plasmodium spp., Leishmania spp., Trypanosoma spp., and T. gondii. We offer a general review of the data from patients and experimental animal models infected with the aforementioned protozoa, which correlate MCs and MC-derived mediators with exacerbated inflammation and disease progression as well as protection against the parasitic infections in different circumstances. This review updates our current understanding of the roles of MCs during parasitic protozoan infections, and the participation of MCs in parasitic protozoan infections could be of a potential therapeutic target.

show abstract

“…It is estimated that over 1 billion people are at risk, 28 indicating that this is one of the neglected tropical diseases 29 with the highest disease burden [3][4][5]. mastigote found in the sandfly vector and the intracellular amastigote, which is present in macrophages and causes the clinical symptoms [9]. Therefore, an antileishmanial compound needs to enter the host macrophage and eliminate the parasites, without damaging the host macrophage.…”

mentioning

confidence: 99%

Systematic search for benzimidazole compounds and derivatives with antileishmanial effects

et al. 2018

View full text Add to dashboard Cite

Leishmaniasis is a neglected tropical disease that currently affects 12 million people, and over 1 billion people are at risk of infection. Current chemotherapeutic approaches used to treat this disease are unsatisfactory, and the limitations of these drugs highlight the necessity to develop treatments with improved efficacy and safety. To inform the rational design and development of more efficient therapies, the present study reports a chemoinformatic approach using the ChEMBL database to retrieve benzimidazole as a target scaffold. Our analysis revealed that a limited number of studies had investigated the antileishmanial effects of benzimidazoles. Among this limited number, L. major was the species most commonly used to evaluate the antileishmanial effects of these compounds, whereas L. amazonensis and L. braziliensis were used least often in the reported studies. The antileishmanial activities of benzimidazole derivatives were notably variable, a fact that may depend on the substitution pattern of the scaffold. In addition, we investigated the effects of a benzimidazole derivative on promastigotes and amastigotes of L. infantum and L. amazonensis using a novel fluorometric method. Significant antileishmanial effects were observed on both species, with L. amazonensis being the most sensitive. To the best of our knowledge, this chemoinformatic analysis represents the first attempt to determine the relevance of benzimidazole scaffolds for antileishmanial drug discovery using the ChEMBL database. The present findings will provide relevant information for future structure-activity relationship studies and for the investigation of benzimidazole-derived drugs as potential treatments for leishmaniasis.

show abstract

Leishmania, the phagosome, and host responses: The journey of a parasite

Cited by 36 publications

References 89 publications

Survival Strategies of <i>Leishmania</i> in Hosts

Survival Strategies of <i>Leishmania</i> in Hosts

The Roles of Mast Cells in Parasitic Protozoan Infections

Systematic search for benzimidazole compounds and derivatives with antileishmanial effects

Contact Info

Product

Resources

About