Leishmaniasis y corazón

Abstract

As one of the neglected tropical diseases, leishmaniasis is defined as a parasitic communicable disease that is most prevalent in tropical and subtropical regions, affecting especially populations living in poverty. It has a profound negative impact on developing economies. It represents a group of heterogeneous syndromes with a wide spectrum of severity ranging from self-resolving cutaneous injuries to disseminated visceral compromise. Visceral leishmaniasis represents its most severe form, can affect almost all organs, and can have fatal consequences, especially in immunosuppressed patients. Cardiac involvement seems to be rare but has not been deeply studied. Consequently, there are no clear recommendations for the screening of cardiac manifestations in these patients. However, cardiovascular complications could be potentially lethal. In addition, there are valuable reports on the potential cardiotoxicity caused by drugs used in the treatment of this condition, so knowledge of its side effects could have important implications. This article is a part of the "Neglected Tropical Diseases and other Infectious Diseases affecting the Heart" project (the NET-Heart Project); its purpose is to review all the information available regarding cardiac implications of this disease and its treatment and to add knowledge to this field of study, focusing on the barriers for diagnosis and treatment, and how to adopt strategies to overcome them.

Diarylpentanoids, the privileged scaffolds in antimalarial and anti‐infectives drug discovery: A review

“…Parasitic infections can lead to sudden cardiac death as the heart muscle and nervous system are destroyed. [157,158] Due to the high toxicity and low efficacy of appropriate drugs, there is an urgent need for the development of new, effective, inexpensive and safe drugs to cure these parasitic diseases to reduce the mortality rate worldwide. SARs suggested that the antiparasitic activity was enhanced by the electron-withdrawing p-nitro substituent on the left aromatic ring.…”

Exploration of ethylene glycol linked nitrofurantoin derivatives against Leishmania: Synthesis and in vitro activity

“…[ 1 ] This disease is classified by the World Health Organisation (WHO) as a neglected tropical disease (NTD) as it is known to mainly affect poorer communities. [ 2 ] There are approximately 20 species that are infectious to humans and they can exist in three clinical forms; that is, cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). [ 3 ]…”