Leishmanicidal activity of fungal bioproducts: A systematic review

Varjão, Márcio Thomaz dos Santos; Duarte, Alysson Wagner Fernandes; Rosa, Luiz Henrique; Alexandre-Moreira, Magna Suzana; Queiroz, Aline Cavalcanti de

doi:10.1016/j.fbr.2022.01.001

Fungal Biology Reviews

2022

DOI: 10.1016/j.fbr.2022.01.001

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Leishmanicidal activity of fungal bioproducts: A systematic review

Márcio Thomaz dos Santos Varjão

Alysson Wagner Fernandes Duarte

Luiz Henrique Rosa

et al.

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2024

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Phytochemical investigation of Nigrospora zimmermanii isolated from Poincianella pluviosa (Sibipiruna): metabolites characterisation and screening for anti-inflammatory activity

Ferreira,

Katchborian-Neto,

Nicácio

et al. 2024

Natural Product Research

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Endophytic fungi residing symbiotically in plant tissues are promising sources of bioactive natural products. This study explored the anti-inflammatory potential of an endophytic fungus isolated from the Brazilian medicinal plant Poincianella pluviosa (Sibipiruna). The extract from the endophyte FPD13 exhibited potential ex vivo anti-inflammatory effects by inhibiting prostaglandin E2 (PGE2) release by 75.22%. Phytochemical analysis using High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR), and Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) enabled the isolation and identification of three compounds, including the macrolide Nigrosporolide, the phenyl-propanol Tyrosol, and the terpene Decarestrictine A. Morphological characteristics and Internal Transcribed Spacers region (ITS) sequencing classified fungus FPD13 as Nigrospora zimmermanii. The results reveal the anti-inflammatory potential and chemical diversity of P. pluviosa endophytes, warranting further investigation into the bioactivity and structure elucidation of their bioactive metabolites.

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Phytochemical investigation of Nigrospora zimmermanii isolated from Poincianella pluviosa (Sibipiruna): metabolites characterisation and screening for anti-inflammatory activity

Ferreira,

Katchborian-Neto,

Nicácio

et al. 2024

Natural Product Research

View full text Add to dashboard Cite

show abstract

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Leishmanicidal activity of fungal bioproducts: A systematic review

Cited by 1 publication

References 110 publications

Phytochemical investigation of Nigrospora zimmermanii isolated from Poincianella pluviosa (Sibipiruna): metabolites characterisation and screening for anti-inflammatory activity

Phytochemical investigation of Nigrospora zimmermanii isolated from Poincianella pluviosa (Sibipiruna): metabolites characterisation and screening for anti-inflammatory activity

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