Leishmanicidal Triterpenes from Lantana camara

Abstract

Two new natural triterpenes, lantaninilic acid and lantoic acid, along with the known triterpenes lantadene A, and oleanolic, ursolic, betulinic, lantanolic, and camaric acid, were obtained from the aerial parts of Lantana camara through bioassay-guided isolation, monitoring the in vitro antileishmanial activity against promastigotes of Leishmania major. Oleanolic acid (3), ursolic acid (4), lantadene A (5), and lantanilic acid (7) showed significant leishmanicidal activities with IC50 values of 53.0, 12.4, 20.4, and 21.3 μM, respectively. The IC50 value of ursolic acid (4; 12.4 μM) was found to be comparable with that of the standard drugs, pentamidine (IC50 15.0 μM) and amphotericin B (IC50 0.31 μM). The in vitro activities of L. camara and its constituents against promastigotes of Leishmania major are reported here for the first time.

Nematicidal Triterpenoids from Lantana camara

“…Thenematicidal activities against Meloidogyne incognita of aMeOH extract of L. camara,its fractions, and various pure compounds have been reported by us in earlier studies [7][10] [11].Inthe present investigation, anew triterpenoid lactone,lancamarolide( 1), along with oleanonic acid (2) [ 12], lantadene A( 3) [ 13], 11a-hydroxy-3oxours-12-en-28-oic acid (4) [ 14], betulinic acid (5) [ 15], lantadene B( 6) [ 16], and lantaninilic acid (7) [17] (Fig. 1)were isolated from L. camara.All of thesecompounds were examinedf or theirn ematicidal activities against M. incognita,t he root-knot nematode.…”

Therapeutic effect of ursolic acid in experimental visceral leishmaniasis

“…The diversity of triterpenes is highly associated with their broad range of pharmacological effects, and different studies have already shown that these compounds present multispecies action against Leishmania sp. (Gnoatto et al., 2008, Bero et al., 2011, Begum et al., 2014). Recently, it was demonstrated that ursolic acid (UA) displayed activity against promastigote and amastigote forms of L. (L.) amazonensis , L. (V.) braziliensis , L. (L.) chagasi , and L. (L.) major (Passero et al., 2011, Begum et al., 2014, Yamamoto et al., 2014, Yamamoto et al., 2015), suggesting that UA presents multispectral action.…”

“…(Gnoatto et al., 2008, Bero et al., 2011, Begum et al., 2014). Recently, it was demonstrated that ursolic acid (UA) displayed activity against promastigote and amastigote forms of L. (L.) amazonensis , L. (V.) braziliensis , L. (L.) chagasi , and L. (L.) major (Passero et al., 2011, Begum et al., 2014, Yamamoto et al., 2014, Yamamoto et al., 2015), suggesting that UA presents multispectral action. In spite of that, few works have performed in vivo studies in order to evaluate the therapeutic potential of this triterpene and, more importantly, up to now there has not been any report analyzing the therapeutic action of this compound on VL, one of the most important medical conditions caused by Leishmania parasites.…”

1H and 13C NMR reassignment of some chemical shifts of lantanilic acid and camaric acid

“…The chemical shifts and their assignments reported by Siddiqui are summarized in Table . Years after this work, more studies have been conducted on 1 and 2 , and they refer to Siddiqui's article for spectral assignments . However, our analysis indicated that eight signals were wrongly assigned.…”

“…Years after this work, more studies have been conducted on 1 and 2, and they refer to Siddiqui's article for spectral assignments. [6][7][8][9][10][11][12][13][14][15][16] However, our analysis indicated that eight signals were wrongly assigned.…”